Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation

doi:10.3748/wjg.v12.i39.6285

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Oct 21, 2006 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Gastric Cancer

World J Gastroenterol. Oct 21, 2006; 12(39): 6285-6289
Published online Oct 21, 2006. doi: 10.3748/wjg.v12.i39.6285

Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation

Liang-Hui Shi, Xiao-Qun Zhu, Guo-Hai Zhao, Ya-Bin Xia, Yi-Sheng Zhang

Liang-Hui Shi, Guo-Hai Zhao, Ya-Bin Xia, Yi-Sheng Zhang, Department of Surgery, Affiliated Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China

Xiao-Qun Zhu, Department of Pathology, Wannan Medical College, Wuhu 241001, Anhui Province, China

Supported by the Department of Education and Natural Science Foundation of Anhui Province, China, No. 2006KJ412B

Correspondence to: Liang-Hui Shi, Department of Surgery, Affiliated Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China. slh1020@tom.com

Telephone: +86-553-5739038 Fax: +86-553-5738100

Received: May 28, 2006
Revised: May 28, 2006
Accepted: July 26, 2006
Published online: October 21, 2006

Abstract

AIM: To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation.

METHODS: Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were detected by EnVision immunohistochemical technique.

RESULTS: Expression of IGFBP-2 in gastric carcinoma was higher than that in normal gastric mucosa (P < 0.01). There was no difference between high- and low-grade gastric carcinoma (P > 0.05). Expression of IGFBP-2 in advanced gastric carcinoma was higher than that in early gastric carcinoma (P < 0.05). Expression of IGFBP-2 in gastric carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.01). IGFBP-2 expression was a positively related to the clinical stage of gastric carcinoma (P < 0.01). There was a positive correlation between IGFBP-2 and Ki-67 (P < 0.05).

CONCLUSION: IGFBP-2 may be involved in carcino-genesis and progression of gastric carcinoma by promoting cell proliferation.

Keywords: Gastric carcinoma; Insulin-like growth factor binding protein; Cell proliferation; Immunohistochemistry