Bromophenacyl bromide, a phospholipase A2 inhibitor attenuates chemically induced gastroduodenal ulcers in rats

doi:10.3748/wjg.v12.i36.5798

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Sep 28, 2006 (publication date) through Nov 12, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Sep 28, 2006; 12(36): 5798-5804
Published online Sep 28, 2006. doi: 10.3748/wjg.v12.i36.5798

Bromophenacyl bromide, a phospholipase A₂ inhibitor attenuates chemically induced gastroduodenal ulcers in rats

Mohammad Tariq, Ibrahim Elfaki, Haseeb Ahmad Khan, Mohammad Arshaduddin, Samia Sobki, Meshal Al Moutaery

Mohammad Tariq, Ibrahim Elfaki, Mohammad Arshaduddin, Meshal Al Moutaery, Research Center, Armed Forces Hospital, Riyadh, Saudi Arabia

Samia Sobki, Division of Clinical Biochemistry, Department of Pathology, Armed Forces Hospital, Riyadh, Saudi Arabia

Haseeb Ahmad Khan, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

Author contributions: All authors contributed equally to the work.

Correspondence to: Professor Mohammad Tariq, PhD, Frcpath, Frsc Senior Consultant and Director of Research, Armed Forces Hospital, Po Box 7897 (W-912), Riyadh 11159, Kingdom of Saudi Arabia. rkh_research@yahoo.com

Telephone: +966-1-4777714-5602

Received: May 13, 2006
Revised: August 5, 2006
Accepted: August 15, 2006
Published online: September 28, 2006

Abstract

AIM: To study the effect of bromophenacyl bromide (BPB), a phospholipase A₂ inhibitor on gastric secretion and to protect chemically induced gastric and duodenal ulcers in rats.

METHODS: Acid secretion studies were undertaken in pylorus-ligated rats with BPB treatment (0, 5, 15 and 45 mg/kg). Gastric and duodenal lesions in the rats were induced by ethanol and cysteamine respectively. The levels of gastric wall mucus, nonprotein sulfhydryls (NP-SH) and myeloperoxidase (MPO) were also measured in the glandular stomach of rats following ethanol induced gastric lesions.

RESULTS: BPB produced a dose-dependent inhibition of gastric acid secretion and acidity in rats. Pretreatment with BPB significantly attenuated the formation of ethanol induced gastric lesion. BPB also protected intestinal mucosa against cysteamine-induced duodenal ulcers. The antiulcer activity of BPB was associated with significant inhibition of ethanol-induced depletion of gastric wall mucus, NP-SH and MPO. These findings pointed towards the mediation of sulfhydryls in BPB induced gastrointestinal cytoprotection.

CONCLUSION: BPB possesses significant antiulcer and cytoprotective activity against experimentally induced gastroduodenal lesions.

Keywords: Bromophenacyl bromide; Phospholipase A₂; Gastric secretion; Gastric ulcer; Duodenal ulcer; Sulfhydryls; Myeloperoxidase