Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis

doi:10.3748/wjg.v12.i3.457

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Jan 21, 2006 (publication date) through Nov 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2006; 12(3): 457-459
Published online Jan 21, 2006. doi: 10.3748/wjg.v12.i3.457

Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis

Chang-Ping Wu, Jing-Ting Jiang, Min Tan, Yi-Bei Zhu, Mei Ji, Kuan-Feng Xu, Jie-Min Zhao, Guang-Bo Zhang, Xue-Guang Zhang

Chang-Ping Wu, Jing-Ting Jiang, Min Tan, Jie-Min Zhao, The Third Affiliated Hospital of Suzhou University, Changzhou 213003, Jiangsu Province, China

Yi-Bei Zhu, Kuan-Feng Xu, Guang-Bo Zhang, Xue-Guang Zhang, Institute of Biotechnology, Suzhou University, Key Laboratory of Clinical Immunology of Jiangsu Province, Suzhou 215007, Jiangsu Province, China

Supported by the National Natural Science Foundation of China, No. 300330540

Correspondence to: Dr Chang-Ping Wu, The Third Affiliated Hospital of Suzhou University, Changzhou 213003, Jiangsu Province, China. newwcp@163.com

Telephone: +86-519-6180260

Received: May 30, 2005
Revised: June 8, 2005
Accepted: June 18, 2005
Published online: January 21, 2006

Abstract

AIM: To investigate the expression of co-stimulatory molecule B7-H3 in gastric carcinoma and adenoma tissue as well as normal gastric tissue and to explore the relationship between B7-H3 expression and pathological features and prognosis of gastric carcinoma.

METHODS: B7-H3 expression was detected in 102 samples of human gastric carcinoma and 10 samples of gastric adenoma and 10 samples of normal gastric tissue by immunohistochemical assay. Correlation between the expression of B7-H3 and the patients’age, sex, gastric carcinoma locus, tumor size, tissue type, tumor infiltration depth, differentiation degree, lymph node metastasis, and survival time was analyzed.

RESULTS: B7-H3 was expressed in all gastric adenoma samples and in 58.8% samples of gastric carcinoma. B7-H3 expression in gastric carcinoma samples was not related with the patients’ age, sex, lymph node metastasis, and tumor size (P > 0.05), but with the survival time, infiltration depth of tumor and tissue type.

CONCLUSION: Detection of B7-H3 expression in gastric carcinoma tissue is beneficial to the judgment of the prognosis of gastric carcinoma patients and the choice of treatment.

Keywords: B7-H3 expression; Gastric carcinoma; Gastric adenoma; Prognosis