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World J Gastroenterol. Aug 7, 2006; 12(29): 4609-4613
Published online Aug 7, 2006. doi: 10.3748/wjg.v12.i29.4609
Published online Aug 7, 2006. doi: 10.3748/wjg.v12.i29.4609
Slow transit constipation: A functional disorder becomes an enteric neuropathy
Gabrio Bassotti, Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Vincenzo Villanacci, 2nd Pathology Section, Spedali Civili, Brescia, Italy
Correspondence to: Dr. Gabrio Bassotti, Clinica di Gastroenterologia ed Epatologia, Via Enrico Dal Pozzo, Padiglione W, Perugia 06100, Italy. gabassot@tin.it
Telephone: +39-75-5783268 Fax: +39-75-5847570
Received: March 17, 2006
Revised: March 23, 2006
Accepted: March 27, 2006
Published online: August 7, 2006
Revised: March 23, 2006
Accepted: March 27, 2006
Published online: August 7, 2006
Abstract
Slow transit constipation has been traditionally considered and classified as a functional disorder. However, clinical and manometric evidence has been accumulating that suggests how most of the motility alterations in STC might be considered of neuropathic type.In addition, further investigations showed that subtle alterations of the enteric nervous system, not evident to conventional histological examination, may be present in these patients. In the present article we will discuss these evidences, and will try to put them in relation with the abnormal motor function of the large bowel documented in this pathological condition.
Keywords: Constipation; Enteric neuropathy; Functional disorders; Slow transit