Leteurtre E, Zerimech F, Piessen G, Wacrenier A, Leroy X, Copin MC, Mariette C, Aubert JP, Porchet N, Buisine MP. Relationships between mucinous gastric carcinoma, MUC2 expression and survival. World J Gastroenterol 2006; 12(21): 3324-3331 [PMID: 16733847 DOI: 10.3748/wjg.v12.i21.3324]
Corresponding Author of This Article
Emmanuelle Leteurtre, INSERM U560, Laboratoire de Recherche Gérard Biserte, Place de Verdun, 59045 Lille cedex, France. e-leteurtre@chru-lille.fr
Article-Type of This Article
Gastric Cancer
Open-Access Policy of This Article
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Emmanuelle Leteurtre, Agnès Wacrenier, Xavier Leroy, Marie-Christine Copin, Service d’Anatomie et Cytologie Pathologiques, Pôle Biologie-Pathologie, Parc Eurasanté. CHR-U de Lille, 59037 Lille cedex, France
Farid Zerimech, Jean-Pierre Aubert, Nicole Porchet, Marie-Pierre Buisine, Service de Biochimie et Biologie Moléculaire, CHR-U de Lille, 59037 Lille cedex, France
Emmanuelle Leteurtre, Xavier Leroy, Marie-Christine Copin, Christophe Mariette, Nicole Porchet, Marie-Pierre Buisine, Faculté de Médecine H. Warembourg, 59045 Lille cedex, France
Guillaume Piessen, Christophe Mariette, Service de Chirurgie Digestive et Générale CAEB, CHR-U de Lille, 59045 Lille cedex, France
Supported by EC Concerted Action N° BMH4-CT98-3222
Correspondence to: Emmanuelle Leteurtre, INSERM U560, Laboratoire de Recherche Gérard Biserte, Place de Verdun, 59045 Lille cedex, France. e-leteurtre@chru-lille.fr
Telephone: +33-3-20298850 Fax: +33-3-20538562
Received: December 29, 2005 Revised: January 8, 2006 Accepted: January 20, 2006 Published online: June 7, 2006
Abstract
AIM: To investigate the expression of the four secreted gel-forming mucins (MUC2, MUC5AC, MUC5B and MUC6) in a series of gastric carcinomas, classified according Laurén’s, Mulligan’s, WHO and Goseki’s classifications, with special attention to all the different components (major and minor) present in tumors and to follow up clinical data.
METHODS: Expression of MUC2, MUC5AC, MUC5B and MUC6 was investigated using immunohistochemistry and in situ hybridization.
RESULTS: Expression of secreted gel-forming mucins in gastric carcinoma was particularly complex, each mucin being not restricted to any histopathological type even considering all components (major and minor) present in a given tumor. There was a worst survival in patients with a higher content of mucus (Goseki II or IV) and high positive MUC2 expression.
CONCLUSION: Complexity of mucin gene expression patterns in gastric cancer may reflect a precise state of differentiation at the cell level not recognized in used morphologic classification systems. High expression of MUC2 was nevertheless associated with mucinous subtype of the WHO classification and with group II of Goseki’s classification identified by the major component of a particular tumor. The quantity and quality of mucus were related to survival.
