Effects of nuclei ambiguus and dorsal motor nuclei of vagus on gastric H+ and HCO3- secretion in rats

doi:10.3748/wjg.v12.i20.3271

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 20

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3636)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-3) series.

Item

Count

PDF

263

HTML

2898

Figures (1-2)

285

Tables (1-3)

190

Sum=3636

May 28, 2006 (publication date) through Nov 6, 2024

Times Cited of This Article

Times Cited (18)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. May 28, 2006; 12(20): 3271-3274
Published online May 28, 2006. doi: 10.3748/wjg.v12.i20.3271

Effects of nuclei ambiguus and dorsal motor nuclei of vagus on gastric H⁺ and HCO₃^- secretion in rats

Xue-Ying Zhang, Hong-Bin Ai, Xi-Yun Cui

Xue-Ying Zhang, Hong-Bin Ai, Xi-Yun Cui, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong Province, China

Author contributions: All authors contributed equally to the work.

Supported by Science Foundation of Shandong Province, No. Y2002D18

Correspondence to: Hong-Bin Ai, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong Province, China. physiology@sdnu.edu.cn

Telephone: +86-531-86185359

Received: August 8, 2005
Revised: October 20, 2005
Accepted: October 26, 2005
Published online: May 28, 2006

Abstract

AIM: To determine the effects of electrical stimulation of nucleus ambiguus (NA) and dorsal motor nuclei of vagus (DMV) on gastric acid and bicarbonate secretion in rats.

METHODS: NA and DMV in rats were electrically stimulated. Pylorus ligation or esophagus perfusion was used to collect the gastric secretion. The titratable H⁺ quantum, H⁺ concentration, HCO₃^- secretion quantum were measured.

RESULTS: Electrical stimulation of NA had no effects on the volume of gastric juice, titratable acidity and acid concentration, but elicited a pronounced increase in the total bicarbonate. However, electrical stimulation of DMV significantly increased the titratable acidity, the volume of gastric juice and the acid concentration. Similarly, electrical stimulation of either NA or DMV decreased the respiratory frequency and sinus bradycardia.

CONCLUSION: NA in rats can not control the secretion of gastric acid but the secretion of bicarbonate in gastric juice, while DMV controls the secretion of gastric acid.

Keywords: Rat; Nucleus ambiguus; Dorsal motor nuclei of vagus; Gastric acid; Gastric bicarbonate