Case Report
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Apr 7, 2006; 12(13): 2136-2138
Published online Apr 7, 2006. doi: 10.3748/wjg.v12.i13.2136
A case of primary biliary cirrhosis complicated by Behçet’s disease and palmoplantar pustulosis
Haruyo Iwadate, Hiromasa Ohira, Hironobu Saito, Atsushi Takahashi, Tsuyoshi Rai, Junko Takiguchi, Tomomi Sasajima, Hiroko Kobayashi, Hiroshi Watanabe, Yukio Sato
Haruyo Iwadate, Hiromasa Ohira, Hironobu Saito, Atsushi Takahashi, Tsuyoshi Rai, Junko Takiguchi, Tomomi Sasajima, Hiroko Kobayashi, Hiroshi Watanabe, Yukio Sato, Department of Internal Medicine II, Fukushima Medical University School of Medicine Fukushima, Japan
Author contributions: All authors contributed equally to the work.
Correspondence to: Haruyo Iwadate, Department of Internal Medicine II, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. haru-i@fmu.ac.jp
Telephone: +81-24-547-1202 Fax: +81-24-547-2055
Received: September 14, 2005
Revised: October 17, 2005
Accepted: October 26, 2005
Published online: April 7, 2006
Abstract

A 46-year-old woman was diagnosed with palmoplantar pustulosis (PPP) at the Department of Dermatology, Fukushima Medical University Hospital in 2000, and was treated with ointment. However, because liver dysfunction developed in 2003, she was referred to our department, where primary biliary cirrhosis (PBC) was also diagnosed on the basis of clinical findings. One year later, at the age of 49, she developed manifestations of Behçet’s disease (BD), including erythema nodosum in the lower extremities. Because she had a history of uveitis, recurrent oral ulceration was present, and the HLA typing was positive for B51, BD was additionally diagnosed. Liver function normalized within three months of the start of treatment with ursodesoxycholic acid (UDCA). This is the first case of PBC associated with BD and PPP.

Keywords: Primary biliary cirrhosis; Behçet’s disease; Palmoplantar pustulosis