Case Report
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Apr 7, 2006; 12(13): 2125-2129
Published online Apr 7, 2006. doi: 10.3748/wjg.v12.i13.2125
Liver cell adenoma: A case report with clonal analysis and literature review
Li Gong, Qin Su, Wei Zhang, Ai-Ning Li, Shao-Jun Zhu, Ying-Ming Feng
Li Gong, Qin Su, Wei Zhang, Ai-Ning Li, Shao-Jun Zhu, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, Shaanxi Province, China
Qin Su, Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Ying-Ming Feng, Department of Oncology, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, Shaanxi Provice, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 30171052 and No. 30572125
Correspondence to: Professor Qin Su, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, Shaanxi Provice, China (current address: Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Beijing 100021, China). q.su@wjgnet.com
Telephone: +86-10-87788435 Fax: +86+10-67713359
Received: October 13, 2005
Revised: November 10, 2005
Accepted: November 16, 2005
Published online: April 7, 2006
Abstract

We report a case of liver cell adenoma (LCA) in a 33-year-old female patient with special respect to its clonality status, pathogenic factors and differential diagnosis. The case was examined by histopathology, immunohistochemistry and a clonality assay based on X-chromosomal inactivation mosaicism in female somatic tissues and polymorphism at androgen receptor focus. The clinicopathological features of the reported cases from China and other countries were compared. The lesion was spherical, sizing 2 cm in its maximal dimension. Histologically, it was composed of cells arranged in cords, most of which were two-cell-thick and separated by sinusoids. Focal fatty change and excessive glycogen storage were observed. The tumor cells were round or polygonal in shape, resembling the surrounding parenchymal cells. Mitosis was not found. No portal tract, central vein or ductule was found within the lesion. The tumor tissue showed a positive reaction for cytokeratin (CK) 18, but not for CK19, vimentin, estrogen and progesterone receptors. Monoclonality was demonstrated for the lesion, confirming the diagnosis of an LCA. Clonality analysis is helpful for its distinction from focal nodular hyperplasia.

Keywords: Liver Cell adenoma; Clonality; Literature review