Case Report
Copyright ©2006 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Mar 14, 2006; 12(10): 1634-1636
Published online Mar 14, 2006. doi: 10.3748/wjg.v12.i10.1634
Jumbo biopsy is useful for the diagnosis of colonic prolapsing mucosal polyps with diverticulosis
Shingo Kato, Kazutoshi Hashiguchi, Ryuichi Yamamoto, Mitsuru Seo, Takashi Matsuura, Kazuro Itoh, Akinori Iwashita, Soichiro Miura
Shingo Kato, Ryuichi Yamamoto, Fukuoka Japan Self Defense Forces Hospital, 1-62 Kokurahigashi, Kasuga, Fukuoka, Japan
Shingo Kato, Kazutoshi Hashiguchi, Ryuichi Yamamoto, Kazuro Itoh, Soichiro Miura, Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan
Mitsuru Seo, Takashi Matsuura, KKR Hamanomachi Hospital, 3-5-27 Maizuru, Chuo-ku, Fukuoka, Japan
Akinori Iwashita, Department of Pathology, Chikushi Hospital, Fukuoka University, 1-1-1 Zukumyoin, Chikushino, Fukuoka, Japan
Author contributions: All authors contributed equally to the work.
Correspondence to: Shingo Kato, Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa City, Saitama 359-8513, Japan. skatos@saitama-med.ac.jp
Telephone: +81-42-9951609 Fax: +81-42-9965201
Received: June 21, 2005
Revised: October 3, 2005
Accepted: November 18, 2005
Published online: March 14, 2006
Abstract

We report here a case of multiple prolapsing mucosal polyps with diverticulosis in the sigmoid colon. A 52-year-old man was admitted to our hospital because of bloody diarrhea. Colonoscopy and barium enema showed multiple diverticula, markedly thickened mucosal folds and polypoid lesions with mucus on the top of them in the sigmoid colon. Endoscopic ultrasonography showed thickening of the mucosal and submucosal layers. Several endoscopic biopsy specimens were taken from the polypoid lesions. Histological examination revealed only chronic inflammatory cell infiltration. In order to obtain a definite diagnosis, we performed endoscopic jumbo biopsy for the polypoid lesions after obtaining informed consent. Histological examination revealed marked lymphocyte infiltration, hemosiderin deposits and fibromuscular obliteration in the lamina propria, features similar to those of mucosal prolapsing syndrome. After anti-diarrhetic treatment, clinical findings were improved. Thus, jumbo biopsy is useful for diagnosis and treatment of prolapsing mucosal polyps.

Keywords: Colon; Diverticulum; Jumbo biopsy; Prolapsing mucosal polyp