Influence of HBcAg in liver cell plasma on expression of transforming growth factor-beta 1 in liver tissue of low-grade chronic hepatitis B patients

doi:10.3748/wjg.v12.i1.127

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jan 7, 2006; 12(1): 127-129
Published online Jan 7, 2006. doi: 10.3748/wjg.v12.i1.127

Influence of HBcAg in liver cell plasma on expression of transforming growth factor-beta 1 in liver tissue of low-grade chronic hepatitis B patients

Yong-Gang Liu, Jian-Hua Lu, Xin-Xin Wang, Jian-Lin Yang, Zhen-Wei Lang, Xin Meng, Li-Jie Zhang, Lin Sun, Shi-Jie Zhang, Jun-Qiang Li, Chen-Zhao Song

Yong-Gang Liu, Department of Clinical Hepatitis, Tianjin Infectious Disease Hospital, Tianjin 300192, China

Jian-Hua Lu, Laboratory of Pathology, Shijiazhuang No. 5 Hospital, Shijiazhuang 050021, Hebei Province, China

Xin-Xin Wang, Zhen-Wei Lang, Xin Meng, Li-Jie Zhang, Lin Sun, Shi-Jie Zhang, Jun-Qiang Li, Chen-Zhao Song, Laboratory of Pathology, Capital Medical University Affiliated Youan Hospital, Beijing 100054, China

Jian-Lin Yang, Laboratory of Pathology, Eerduosi No. 2 People’s Hospital, Eerduosi 017000, Inner Mongolia Autonomous Region, China

Co-first-author: Jian-Hua Lu

Supported by the Beijing Science and Technology Commission, No. H020920020290

Correspondence to: Dr. Yong-Gang Liu, Tianjin Infectious Disease Hospital, Tianjin 300192, China. ygwx@public.tpt.tj.cn

Telephone: +86-22-23004472

Received: May 25, 2005
Revised: June 8, 2005
Accepted: June 18, 2005
Published online: January 7, 2006

Abstract

AIM: To study the influence of HBcAg on the expression of transforming growth factor-beta 1 (TGF-β1) in liver tissue of low-grade chronic hepatitis B (CHB) patients.

METHODS: The expression of TGF-β1 and HBcAg in liver samples from 93 low-grade CHB patients was detected by immunohistochemistry and valuated by semi-quantitative scoring.

RESULTS: In the 93 low-grade CHB patients, HBcAg was expressed in cell plasma but not in the liver tissue. There was no significant difference between the two groups.

CONCLUSION: The expression of TGF-β1 is not related with HBcAg expressed as plasma type in the tissues of low-grade CHB patients.

Keywords: HBcAg; Factor-beta 1; Chronic hepatitis B