Peng NJ, Lai KH, Liu RS, Lee SC, Tsay DG, Lo CC, Tseng HH, Huang WK, Lo GH, Hsu PI. Capsule 13C-urea breath test for the diagnosis of Helicobacter pylori infection. World J Gastroenterol 2005; 11(9): 1361-1364 [PMID: 15761976 DOI: 10.3748/wjg.v11.i9.1361]
Corresponding Author of This Article
Dr. Ping-I Hsu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan, China. williamhsup@yahoo.com.tw
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Peng NJ, Lai KH, Liu RS, Lee SC, Tsay DG, Lo CC, Tseng HH, Huang WK, Lo GH, Hsu PI. Capsule 13C-urea breath test for the diagnosis of Helicobacter pylori infection. World J Gastroenterol 2005; 11(9): 1361-1364 [PMID: 15761976 DOI: 10.3748/wjg.v11.i9.1361]
Nan-Jing Peng, Daw-Guey Tsay, Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, China
Kwok-Hung Lai, Ching-Chu Lo, Gin-Ho Lo, Ping-I Hsu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, China
Huei-Hwa Tseng, Wen-Keui Huang, Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, China
Ren-Shyan Liu, Department of Nuclear Medicine, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan, China
Shui-Cheng Lee, Institute of Nuclear Energy Research, Taoyuan, Taiwan, China
Author contributions: All authors contributed equally to the work.
Supported by Grant From the National Science Council, Taiwan NSC 90-2314-B-075B-008
Correspondence to: Dr. Ping-I Hsu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung 813, Taiwan, China. williamhsup@yahoo.com.tw
Received: July 17, 2004 Revised: July 18, 2004 Accepted: September 9, 2004 Published online: March 7, 2005
Abstract
AIM: To compare the accuracy of capsule 13C-urea breath test (UBT) with conventional invasive methods for the diagnosis of Helicobacter pylori infection.
METHODS: One hundred patients received CLO test, histological examination, culture and 100- or 50-mg capsule UBT for the diagnosis of H pylori infection. H pylori infection was defined as those with positive culture or positive results from both histology and CLO test.
RESULTS: Both the sensitivity and specificity of the 100-mg capsule UBT (n = 50) were 100%. The sensitivity and specificity of the 50-mg capsule UBT (n = 50) were 96.4 and 100%, respectively. Taken together, the accuracy of capsule UBT (n = 100) was higher than that of CLO test, histology and culture (100% vs 92%, 91% and 89%, respectively; P = 0.035, 0.018 and 0.005, respectively). Our data showed that the optimal timing of sampling for 100- and 50-mg capsule UBT was 15-30 and 6-15 min, respectively.
CONCLUSION: Capsule UBT has a higher accuracy compared with biopsy-based tests. It is an ideal method for the diagnosis of H pylori infection.
