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Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2005; 11(47): 7512-7514
Published online Dec 21, 2005. doi: 10.3748/wjg.v11.i47.7512
Baseline characterization of patients aged 70 years and above with hepatocellular carcinoma
Makoto Nakamuta, Shusuke Morizono, Motoyuki Kohjima, Kazuhiro Kotoh, Munechika Enjoji
Makoto Nakamuta, Shusuke Morizono, Motoyuki Kohjima, Kazuhiro Kotoh, Munechika Enjoji, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Author contributions: All authors contributed equally to the work.
Correspondence to: Makoto Nakamuta, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-5282, Japan. nakamuta@intmed3.med.kyushu-u.ac.jp
Telephone: +81-92-642-5282 Fax: +81-92-642-5287
Received: March 28, 2005
Revised: May 20, 2005
Accepted: May 24, 2005
Published online: December 21, 2005
Abstract

AIM: To characterize the baseline profiles of patients aged 70 years and above with hepatocellular carcinoma (HCC).

METHODS: A series of 127 consecutive patients with HCC were enrolled between 2000 and 2004, and none of them had been diagnosed as having HCC previously. Baseline profiles, including parameters of hepatic function such as serum transaminase and prothrombin time [PT (% activity)] were compared between patients aged ≥70 and <70 years.

RESULTS: Patients ≥70 years old showed significantly lower levels of aspartate aminotransferase (P = 0.04) and alanine aminotransferase (P = 0.01), and significantly higher PTs (P = 0.04) and platelet counts (P = 0.02). Concomitantly, among ≥70-year-old patients, HCC was more common in non-cirrhotics, whereas among patients <70 years old, HCC was more common in cirrhotics. There was no significant difference between the groups in the number or size of tumors.

CONCLUSION: Older HCC patients showed less inflammation and better preservation of hepatic function, indicating that not only cirrhotic patients but also non-cirrhotic patients should be considered as a high-risk group among the elderly.

Keywords: Hepatocellular carcinoma; Elderly patients; Baseline profile; Non-cirrhosis