Effect of oral Lactococcus lactis containing endostatin on 1, 2-dimethylhydrazine-induced colon tumor in rats

doi:10.3748/wjg.v11.i46.7242

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Dec 14, 2005 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Dec 14, 2005; 11(46): 7242-7247
Published online Dec 14, 2005. doi: 10.3748/wjg.v11.i46.7242

Effect of oral Lactococcus lactis containing endostatin on 1, 2-dimethylhydrazine-induced colon tumor in rats

Wei Li, Chong-Bi Li

Wei Li, Department of Obstetrics and Gynecology, First People’s Hospital of Hangzhou, Hangzhou 310006, Zhejiang Province, China

Chong-Bi Li, Department of Biology, Zhaoqing College, Zhaoqing 526000, Guangdong Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Chong-Bi Li, Department of Biology, Zhaoqing College, Zhaoqing 526000, Guangdong Province, China. lchongbi@yahoo.com

Telephone: +86-758-2716359 Fax: +86-758-2776882

Received: February 17, 2005
Revised: July 1, 2005
Accepted: July 4, 2005
Published online: December 14, 2005

Abstract

AIM: To investigate the effects of oral Lactococcus lactis (L lactis) containing endostatin on 1, 2-dimethylhydrazine (DMH)-induced rat colorectal cancer.

METHODS: Recombinant endostatin was produced by the expression of L lactis NZ9000. Sixty male Wistar rats were injected with DMH (40 mg/kg body weight) subcutaneously once a week for 10 wk to induce colorectal cancer. The rats were gavaged with 1 mL of endostatin at a dose of 1×10⁸/d and fed with the basal diet. The animals were killed after 22 wk for histopathological examination. The total time of experimental observation was 58 wk.

RESULTS: Rat endostatin protein was expressed in L lactis. Recombinant endostatin exhibited a significant effect on colorectal cancer (P<0.05). Furthermore, the mean survival time of the rats treated with endostatin was longer than that of the animals treated with DMH. There was no statistically significant difference between the rats treated with endostatin and those treated with DMH. The results showed that endostatin could not result in complete cure.

CONCLUSION: Oral endostatin exerts an influence on the progression of chemically induced colon tumors.

Keywords: Endostatin; DMH; Tumors