Brief Reports
Copyright ©The Author(s) 2005. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2005; 11(36): 5718-5720
Published online Sep 28, 2005. doi: 10.3748/wjg.v11.i36.5718
Expression of HBsAg and HBcAg in the ovaries and ova of patients with chronic hepatitis B
Feng Ye, Ya-Fei Yue, Shu-Hong Li, Tian-Yan Chen, Shu-Ling Zhang, Gui-Qin Bai, Min Liu
Feng Ye, Tian-Yan Chen, Shu-Ling Zhang, Min Liu, Department of Infectious Disease, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Ya-Fei Yue, Shu-Hong Li, Gui-Qin Bai, Department of Obstetrics and Gynecology, First Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 30371277
Correspondence to: Dr. Feng Ye, Department of Infectious Disease, First Hospital of Xi’an Jiaotong University, Jiankang Road 1#, Xi’an 710061, Shaanxi Province, China. yefeng.jiaotong@163.com
Telephone: +86-29-88042433 Fax: +86-29-5252812
Received: January 14, 2005
Revised: February 13, 2005
Accepted: February 18, 2005
Published online: September 28, 2005
Abstract

AIM: To investigate the expression and distribution of HBV in the ovaries and ova.

METHODS: The immunohistochemistry method was used to detect the HBsAg and HBcAg in the ovaries of patients with chronic hepatitis B.

RESULTS: Expression of HBsAg in the ova, granular and interstitial cells of the ovaries was located in the cytomembrane and cytoplasm. Expression of HBcAg in the ova, granular, interstitial and endothelial cells of interstitial blood vessels of the ovaries was found in the cytomembrane, cytoplasm, and nuclei.

CONCLUSION: HBV can infect the ova at different stages of development and replicate in it.

Keywords: HBV; Ovaries; Ova; Immunohistochemistry