Tang W, Inagaki Y, Kokudo N, Guo Q, Seyama Y, Nakata M, Imamura H, Sano K, Sugawara Y, Makuuchi M. KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression. World J Gastroenterol 2005; 11(35): 5450-5454 [PMID: 16222735 DOI: 10.3748/wjg.v11.i35.5450]
Corresponding Author of This Article
Dr. Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. tang-sur@h.u-tokyo.ac.jp
Article-Type of This Article
Basic Research
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Wei Tang, Norihiro Kokudo, Qian Guo, Yasuji Seyama, Hiroshi Imamura, Keiji Sano, Yasuhiko Sugawara, Masatoshi Makuuchi, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Yoshinori Inagaki, Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259-1292, Japan
Munehiro Nakata, Department of Applied Biochemistry and Institute of Glycotechnology, Tokai University, Hiratsuka, Kanagawa 259-1292, Japan
Author contributions: All authors contributed equally to the work.
Supported by Grants-in-aid From the Ministry of Education, Science, Sports, and Culture of Japan and a grant for Hi-Tech Research from Tokai University
Correspondence to: Dr. Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. tang-sur@h.u-tokyo.ac.jp
Telephone: +81-3-5800-8654 Fax: +81-3-5684-3989
Received: March 1, 2005 Revised: April 6, 2005 Accepted: April 9, 2005 Published online: September 21, 2005
Abstract
AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.
METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohi-stochemical analysis using KL-6 antibody.
RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).
CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.
Tang W, Inagaki Y, Kokudo N, Guo Q, Seyama Y, Nakata M, Imamura H, Sano K, Sugawara Y, Makuuchi M. KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression. World J Gastroenterol 2005; 11(35): 5450-5454 [PMID: 16222735 DOI: 10.3748/wjg.v11.i35.5450]
