Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor

doi:10.3748/wjg.v11.i32.5032

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2005; 11(32): 5032-5036
Published online Aug 28, 2005. doi: 10.3748/wjg.v11.i32.5032

Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor

Ge Lou, Ying Gao, Xiao-Ming Ning, Qi-Fan Zhang

Ge Lou, Ying Gao, Xiao-Ming Ning, Qi-Fan Zhang, Tumor Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China

Author contributions: All authors contributed equally to the work.

Supported by Foundation for Scholars Abroad of Ministry of Education of China, No. [2003]406, and Foundation of Heilongjiang Office of Education, No. 9551138

Correspondence to: Ge Lou, Department of Gynecology, Tumor Hospital of Harbin Medical University, Harbin 150040, Heilongjiang Province, China. dr-lg911@163.com

Telephone: +86-451-86677580-2133

Received: October 9, 2004
Revised: December 4, 2004
Accepted: December 9, 2004
Published online: August 28, 2005

Abstract

AIM: To explore the expression and correlation of CD44v6, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and matrix metalloproteinase (MMP)-9 in Krukenberg and primary epithelial ovarian carcinoma.

METHODS: The expressions of CD44v6, VEGF, MMP-2 and MMP-9 were detected by immunohistochemical method in 20 cases of normal ovarian tissues, 38 cases of Krukenberg tumor and 45 cases of primary epithelial ovarian carcinoma.

RESULTS: The expression of CD44v6 (primary epithelial ovarian carcinoma tissue vs normal ovarian tissue: χ² = 4.516, P = 0.034; Krukenberg tumor tissue vs normal ovarian tissue: χ² = 19.537, P = 0.001) and VEGF (primary epithelial ovarian carcinoma tissue vs normal ovarian tissue: P = 0.026; Krukenberg tumor tissue vs normal ovarian tissue: χ² = 22.895, P = 0.001) was significantly higher in primary epithelial ovarian carcinoma tissue and Krukenberg tumor tissue than in normal ovarian tissue. The positive expression rate of MMP-2 and MMP-9 was 0% in the normal ovarian tissue. The positive expression rate of CD44v6 (χ² = 10.398, P = 0.001), VEGF (χ² = 13.149, P = 0.001), MMP-2 (χ² = 33.668, P = 0.001) and MMP-9 (χ² = 38.839, P = 0.001) was remarkably higher in Krukenberg tumor than in primary epithelial ovarian carcinoma. The correlation of CD44v6, VEGF, MMP-2, and MMP-9 was observed in primary epithelial ovarian carcinoma and Krukenberg tumor.

CONCLUSION: CD44v6, VEGF, MMP-2, and MMP-9 are involved in ovarian carcinoma, gastric cancer and Krukenberg tumor. Detection of CD44v6, VEGF, MMP-2 and MMP-9 may contribute to the diagnosis of ovarian carcinoma, gastric cancer, and Krukenberg tumor.

Keywords: CD44v6; VEGF; MMPs; Krukenberg tumor