MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma

doi:10.3748/wjg.v11.i32.4939

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 11, Issue 32

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3785)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-4) series.

Item

Count

PDF

398

HTML

2972

Figures (1-2)

208

Tables (1-4)

207

Sum=3785

Aug 28, 2005 (publication date) through Nov 23, 2024

Times Cited of This Article

Times Cited (40)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Aug 28, 2005; 11(32): 4939-4946
Published online Aug 28, 2005. doi: 10.3748/wjg.v11.i32.4939

MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma

Chanchai Boonla, Banchob Sripa, Peti Thuwajit, Ubon Cha-On, Anucha Puapairoj, Masanao Miwa, Sopit Wongkham

Chanchai Boonla, Peti Thuwajit, Ubon Cha-On, Sopit Wongkham, Department of Biochemistry, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

Banchob Sripa, Anucha Puapairoj, Department of Pathology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

Masanao Miwa, Institute of Basic Medical Sciences, University of Tskuba, Tsukuba, Ibaraki 305-8575, Japan

Author contributions: All authors contributed equally to the work.

Supported by the Thailand Research Fund, No. BRG/06/2544 and Royal Golden Jubilee PhD Program Grant, No. PHD/0045/2542 to Boonla C and Wongkham S

Correspondence to: Dr. Sopit Wongkham, Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. sopit@kku.ac.th

Telephone: +66-43-348-386 Fax: +66-43-348-375

Received: November 23, 2004
Revised: January 23, 2005
Accepted: January 26, 2005
Published online: August 28, 2005

Abstract

AIM: To investigate the expressions of MUC1 and MUC5AC in intrahepatic cholangiocarcinoma (ICC). Association of expressions of mucins MUC1 and MUC5AC with clinical findings, metastasis, and survival of the liver fluke-associated ICC patients was determined.

METHODS: The expressions of MUC1 and MUC5AC mucins were examined by immunohistochemical staining in 87 cases of histologically-proven ICC. The expressions of mucins in relationship between clinicopathological significance and prognosis of the patients were evaluated.

RESULTS: Fifty-two patients (60%) exhibited both MUC1 and MUC5AC expressions, whereas 31% expressed either MUC1 or MUC5AC, and 9% expressed neither. High MUC1 immunoreactivity displayed a significant correlation with tumor progression as reflected by vascular invasion (P<0.001), whereas high expression of MUC5AC significantly correlated with neural invasion (P = 0.022) and advanced ICC stage (P = 0.008). Patients with high expression of MUC1 had a significantly shorter survival (P = 0.0002). According to multivariate analyses, MUC1 reactivity (P = 0.026), histological grading and stage of tumor represented the least probability of survival.

CONCLUSION: MUC1 is overexpressed in liver fluke-associated cholangiocarcinoma and relates to vascular invasion and poor prognosis, whereas MUC5AC mucin is neoexpressed and relates to neural invasion and advanced ICC stage. High MUC1 expression in tumor may be useful for predicting the poor outcome of ICC patients.

Keywords: Cholangiocarcinoma; Mucin; MUC1; MUC5AC; Invasion; Survival; Immunohistochemistry