Gao SG, Wang LD, Fan ZM, Li JL, He X, Guo RF, Xie DL, He XW, Gao SS, Guo HQ, Wang JK, Feng XS, Ma BG. Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China. World J Gastroenterol 2005; 11(30): 4634-4637 [PMID: 16094701 DOI: 10.3748/wjg.v11.i30.4634]
Corresponding Author of This Article
Li-Dong Wang, MD, Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou 450052, Henan Province, China. lidong0823@sina.com
Article-Type of This Article
Gastric Cancer
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
She-Gan Gao, Li-Dong Wang, Zong-Min Fan, Xin He, Rui-Feng Guo, Dong-Ling Xie, Xin-Wei He, Shan-Shan Gao, Hua-Qin Guo, Jun-Kuan Wang, Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Ji-Lin Li, Department of Pathology, Linzhou Esophageal Cancer Hospital, Linzhou, Henan Province, China
She-Gan Gao, Xiao-Shan Feng, Department of Clinical Oncology, The First Affiliated Hospital of Henan Science and Technology University, Luoyang 471001, Henan Province, China
Bao-Gen Ma, Department of Oncology, Henan Tumor Hospital, Zhengzhou 450003, Henan Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Outstanding Young Scientist Award of China, No. 30025016, State Key Project for Basic Research, No. G1998051206, Foundation of Henan Education Committee 1999125 and the US NIH Grant, No. CA65871
Correspondence to: Li-Dong Wang, MD, Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Zhengzhou 450052, Henan Province, China. lidong0823@sina.com
Telephone: +86-371-6658335 Fax: +86-371-6658335
Received: September 9, 2004 Revised: December 18, 2004 Accepted: December 21, 2004 Published online: August 14, 2005
Abstract
AIM: To characterize the histochemical type and pattern of intestinal metaplasia (IM) adjacent to gastric cardia adenocarcinoma (GCA) and distal gastric cancer (GC) in Linzhou, Henan Province, China.
METHODS: Alcian-blue-periodic acid Schiff and high iron diamine-Alcian blue histochemical methods were performed on 142 cases of IM, including 49 cases of GCA and 93 cases of GC. All the patients were from Linzhou, Henan Province, China, the highest incidence area for both GCA and squamous cell carcinoma. Radio- or chemotherapy was not applied to these patients before surgery.
RESULTS: The detection rate of IM in tissues adjacent to GCA tissues was 44.9%, which was significantly lower than that in GC tissues (80.64%, P < 0.01). The rates of both incomplete small intestinal and colonic IM types identified by histochemistry in GCA tissues (31.82% and 63.64%, respectively) were significantly higher than those in GC (5.33% and 21.33%, respectively, P < 0.01).
CONCLUSION: IM in GCA and GC should be considered as a separate entity. Further research is needed to evaluate whether neoplastic progression of IM is related to its mucin profile in GCA.
