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©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2005; 11(20): 3011-3013
Published online May 28, 2005. doi: 10.3748/wjg.v11.i20.3011
Published online May 28, 2005. doi: 10.3748/wjg.v11.i20.3011
Research progress on Helicobacter pylori outer membrane protein
Shi-He Shao, Shun-Gen Chai, Department of Medical Microbiology and Parasitology, Medical Technology College, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
Hua Wang, Li-Mei Liu, Graduate Student, Medical College, Northern University, Jilin 132001, Jilin Province, China
Author contributions: All authors contributed equally to the work.
Supported by the Research Plan of Jiangsu Provincial Technology Commission, No. BS2004021; Advanced Talent Research Plan of Jiangsu University, No. JDG2004008
Correspondence to: Shi-He Shao, Department of Medical Microbiology and Parasitology, Medical Technology College, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China. ljxwl123@163.com
Telephone: +86-511-2165735
Received: November 8, 2004
Revised: November 9, 2004
Accepted: December 3, 2004
Published online: May 28, 2005
Revised: November 9, 2004
Accepted: December 3, 2004
Published online: May 28, 2005
Abstract
Helicobacter pylori (H pylori), one of the most common bacterial pathogens on human beings, colonizes the gastric mucosa. In its 95 paralogous gene families, there is a large outer membrane protein (OMP) family. It includes 32 members. These OMP are important for the diagnosis, protective immunity, pathogenicity of H pylori and so on. They are significantly associated with high H pylori density, the damage of gastric mucosa, high mucosal IL-8 levels and severe neutrophil infiltration. We introduce their research progress on pathogenicity.
Keywords: H pylori; Outer membrane protein; oipA; Gastric carcinoma