Rectosigmoid findings are not associated with proximal colon cancer: Analysis of 6196 consecutive cases undergoing total colonoscopy

doi:10.3748/wjg.v11.i15.2249

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Apr 21, 2005 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Apr 21, 2005; 11(15): 2249-2254
Published online Apr 21, 2005. doi: 10.3748/wjg.v11.i15.2249

Rectosigmoid findings are not associated with proximal colon cancer: Analysis of 6196 consecutive cases undergoing total colonoscopy

Makoto Okamoto, Takao Kawabe, Yutaka Yamaji, Jun Kato, Tsuneo Ikenoue, Goichi Togo, Haruhiko Yoshida, Yasushi Shiratori, Masao Omata

Makoto Okamoto, Takao Kawabe, Yutaka Yamaji, Jun Kato, Tsuneo Ikenoue, Goichi Togo, Haruhiko Yoshida, Yasushi Shiratori, Masao Omata, Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan

Author contributions: All authors contributed equally to the work.

Correspondence to: Makoto Okamoto, MD, Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. okamoto-2im@h.u-tokyo.ac.jp

Telephone: +81-3-3815-5411-33056 Fax: +81-3-3814-0021

Received: May 7, 2004
Revised: May 8, 2004
Accepted: November 30, 2004
Published online: April 21, 2005

Abstract

AIM: To review the risk of proximal colon cancer in patients undergoing colonoscopy.

METHODS: We estimated the risk of advanced proximal adenomas and cancers in 6196 consecutive patients that underwent colonoscopy (mean age 60 years, 65% males, without prior history of colorectal examination). Neoplasms were classified as diminutive adenoma (5 mm or less), small adenoma (6-9 mm), advanced adenoma (10 mm or more, with villous component or high-grade dysplasia) and cancer (invasive adenocarcinoma). The sites of neoplasms were defined as rectosigmoid (rectum and sigmoid colon) and proximal colon (from cecum to descending colon).

RESULTS: The trend of the prevalence of advanced proximal adenoma was to increase with severe rectosigmoid findings, while the prevalence of proximal colon cancer did not increase with severe rectosigmoid findings. Among the 157 patients with proximal colon cancer, 74% had no neoplasm in the rectosigmoid colon. Multivariate logistic-regression analysis revealed that age was the main predictor of proximal colon cancer and existence of rectosigmoid adenoma was not a predictor of proximal colon cancer.

CONCLUSION: Sigmoidoscopy is inadequate for colorectal cancer screening, especially in older populations.

Keywords: Colorectal cancer; Advanced adenoma; Rectosigmoid colon; Proximal colon