Colorectal Cancer
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 1, 2004; 10(9): 1297-1300
Published online May 1, 2004. doi: 10.3748/wjg.v10.i9.1297
Amino acid uptake in arterio-venous serum of normal and cancerous colon tissues
Lin-Bo Wang, Jian-Guo Shen, Su-Zhan Zhang, Ke-Feng Ding, Shu Zheng
Lin-Bo Wang, Jian-Guo Shen, Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University Medical College, Hangzhou 310016, Zhejiang Province, China
Su-Zhan Zhang, Ke-Feng Ding, Shu Zheng, Department of Surgical Oncology, the Second Hospital, Zhejiang University Medical College, Hangzhou 310016, Zhejiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by Oncology Research Institute, Medical College, Zhejiang University
Correspondence to: Dr. Lin-Bo Wang, Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University Medical College, Hangzhou 310016, Zhejiang Province, China. wanglinbo@medmail.com.cn
Telephone: +86-571-86090073 Fax: +86-571-86044817
Received: August 2, 2003
Revised: September 20, 2003
Accepted: October 12, 2003
Published online: May 1, 2004
Abstract

AIM: To investigate the difference of amino acid uptake between normal and cancerous colon tissues.

METHODS: Sixteen patients with colon cancer were enrolled in our study. Blood samples were taken during operations, serum amino acid concentrations of blood from cancerous or normal colon were analyzed. Amino acid uptake rate was calculated by the A-V difference and evaluated statistically.

RESULTS: Except for methionine, the uptake rate of amino acids in cancer was higher than that in normal colon (25.01% vs -2.29%, P < 0.01). The amino acid uptake rate did not correlate to the size of tumor mass (P > 0.05). There was no statistical significance in the amino acid uptake rate according to the Dukes stage, though it was higher in patients with Dukes stage C or D than that with Dukes stage B (P > 0.05).

CONCLUSION: Abnormal synthetic metabolism of colon cancer may contribute to its higher amino acid uptake rate than that of normal colon.

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