Liver Cancer
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 1, 2004; 10(9): 1292-1296
Published online May 1, 2004. doi: 10.3748/wjg.v10.i9.1292
Effects of recombinant human growth hormone on remnant liver after hepatectomy in hepatocellular carcinoma with cirrhosis
Shi-Min Luo, Li-Jian Liang, Jia-Ming Lai
Shi-Min Luo, Li-Jian Liang, Jia-Ming Lai, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Li-Jian Liang, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, 56 Zhongshan Er Lu, Guangzhou 510080, Guangdong Province, China. liangpw@gzsums.edu.cn
Telephone: +86-20-87755766-8096 Fax: +86-20-87755766-8663
Received: November 11, 2003
Revised: December 1, 2003
Accepted: December 16, 2003
Published online: May 1, 2004
Abstract

AIM: To explore the effects of recombinant human growth hormone (rhGH) on the remnant liver after hepatectomy in hepatocellular carcinoma with liver cirrhosis.

METHODS: Twenty-four patients with hepatocellular carcinoma who underwent hepatectomy were randomly divided into 2 groups: parenteral nutrition (PN) group (n = 12) and rhGH+PN group (n = 12). Liver function, blood glucose, AFP, serum prealbumin and transferrin were detected before operation, at post-operative d 1 and d 6. Albumin (ALB) mRNA in liver biopsy specimens was detected by RT-PCR at post-operative d 6. Liver Ki67 immunohistochemical staining was studied.

RESULTS: On post-operative d 6, compared with PN group, the levels of blood glucose, serum prealbumin, transferrin, the expression of hepatic ALB mRNA and liver Ki67 labeling index were higher in rhGH + PN group.

CONCLUSION: rhGH can improve protein synthesis and liver regeneration after hepatectomy in hepatocellular carcinoma with liver cirrhosis.

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