Brief Reports
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 15, 2004; 10(8): 1218-1221
Published online Apr 15, 2004. doi: 10.3748/wjg.v10.i8.1218
Effects of hemoperfusion adsorption and/or plasma exchange in treatment of severe viral hepatitis: A comparative study
Nian-Hai He, Ying-Jie Wang, Ze-Wen Wang, Jun Liu, Jia-Jia Li, Guo-Dong Liu, Yu-Ming Wang
Nian-Hai He, Ying-Jie Wang, Ze-Wen Wang, Jun Liu, Jia-Jia Li, Guo-Dong Liu, Yu-Ming Wang, Research Institute of Infectious Disease, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.30027001
Correspondence to: Dr. Ying-Jie Wang, Research Institute of Infectious Disease, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Zhengjie, Chongqing 400038, China. wangyj103@263.net
Telephone: +86-23-68754475-8062 Fax: +86-23-65334998
Received: September 15, 2003
Revised: November 23, 2003
Accepted: December 8, 2003
Published online: April 15, 2004
Abstract

AIM: Non-bioartificial liver has been applied to clinic for quite a long time, but the reported efficacy has been very different. The aim of this study was to compare the efficacy and safety of hemoperfusion adsorption, plasma exchange and plasma exchange plus hemoperfusion adsorption in treatment of severe viral hepatitis.

METHODS: Seventy-five patients with severe viral hepatitis were treated with hemoperfusion adsorption therapy (24 cases), plasma exchange therapy (17 cases) and plasma exchange plus hemoperfusion adsorption therapy (34 cases). The data of liver function, renal function, blood routine test, prothrombin time (PT) and prothrombin activity (PTa) pre-and post-therapy were analyzed.

RESULTS: Clinical symptoms of patients improved after treatment. The levels of aminotransferase, total bilirubin, direct bilirubin decreased significantly after 3 therapies (P < 0.05 or P < 0.01). PT, the level of total serum protein decreased significantly and PTa increased significantly after plasma exchange therapy and plasma exchange plus hemoperfusion adsorption therapy (P < 0.05 or P < 0.01). The side effects were few and mild in all patients.

CONCLUSION: Three therapies were effective in the treatment of severe viral hepatitis. Plasma exchange therapy and plasma exchange plus hemoperfusion adsorption therapy are better than hemoperfusion adsorption therapy.

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