Brief Reports
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 1, 2004; 10(5): 747-749
Published online Mar 1, 2004. doi: 10.3748/wjg.v10.i5.747
Clinical evaluation of four one-week triple therapy regimens in eradicating Helicobacter pylori infection
Chuan-Yong Guo, Yun-Bin Wu, Heng-Lu Liu, Jian-Ye Wu, Min-Zhang Zhong
Chuan-Yong Guo, Yun-Bin Wu, Heng-Lu Liu, Jian-Ye Wu, Min-Zhang Zhong, Department of Gastroenterology, Tielu hospital of Tongji University, Shanghai 200072, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Chuan-Yong Guo, Department of Gastroenterology, Tielu Hospital of Tongji University, Shanghai 200072, China. guochuanyong@hotmail.com
Telephone: +86-21-56779971 Fax: +86-21-66303983
Received: June 4, 2003
Revised: July 17, 2003
Accepted: July 24, 2003
Published online: March 1, 2004
Abstract

AIM: To evaluate clinical efficacy of four one-week triple therapies in eradicating Helicobacter pylori infection.

METHODS: In this clinical trial, 132 patients with duodenal ulcer and chronic gastritis were randomly divided into four groups, and received treatment with OAC (omeprazole 20 mg + amoxicillin 1000 mg + clarithromycin 250 mg), OFC (omeprazole 20 mg + furazolidone 100 mg + clarithromycin 250 mg), OFA (omeprazole 20 mg + furazolidone 100 mg + amoxicillin 1000 mg) and OMC (omeprazole 20 mg + metronidazole 200 mg + clarithromycin 250 mg), respectively. Each drug was taken twice daily for one week. The 13C urea breath test was carried out 4-8 weeks after treatment to determine the success of H pylori eradication.

RESULTS: A total of 127 patients completed the treatment. The eradication rate for H pylori infection was 90.3%, 90.9%, 70.9% and 65.6%, respectively in OAC, OFC OMC and OFA groups.

CONCLUSION: A high eradication rate can be achieved with one-week OAC or OFC triple therapy. Thus, one-week triple therapies with OAC and OFC are recommended for Chinese patients with duodenal ulcers and chronic gastritis.

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