Expression of HIF-2&alpha;/EPAS1 in hepatocellular carcinoma

doi:10.3748/wjg.v10.i4.525

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Feb 15, 2004 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Feb 15, 2004; 10(4): 525-530
Published online Feb 15, 2004. doi: 10.3748/wjg.v10.i4.525

Expression of HIF-2α/EPAS1 in hepatocellular carcinoma

Gassimou Bangoura, Lian-Yue Yang, Gen-Wen Huang, Wei Wang

Gassimou Bangoura, Lian-Yue Yang, Gen-We Huang, Wei-Wang, Department of General Surgery and Liver Cancer Laboratory, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China

Author contributions: All authors contributed equally to the work.

Supported by the National Key Technologies R and D Program, No. 2001BA703B04

Correspondence to: Professor Lian-Yue Yang, Department of General Surgery and Liver Cancer Laboratory, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China. lianyueyang@hotmail.com

Telephone: +86-731-4327326 Fax: +86-731-4327232

Received: June 16, 2003
Revised: August 23, 2003
Accepted: October 7, 2003
Published online: February 15, 2004

Abstract

AIM: To investigate the expression of hypoxia-inducible factor (HIF)-2α/endothelial PAS domain protein1 (EPAS1) in hepatocellular carcinoma (HCC).

METHODS: Expression of HIF-2α/EPAS1 was investigated immunohistochemically on paraffin-embedded sections from 97 patients with HCC. To further confirm that HIF-2α/EPAS1 in HCC tissues also correlated with angiogenesis, a parallel immunohistchemistry study of vascular endothelial growth factor (VEGF) was performed on these 97 cases.

RESULTS: HIF-2α/EPAS1 could be detected in 50 of 97 cases (51.6%), including 19 weakly positive (19.8%), and 31 strongly positive (31.1%), the other 47 cases were negative (48.4%). The expression of HIF-2α/EPAS1was significantly correlated with tumor size, capsule infiltration, portal vein invasion, and necrosis. A parallel immunohistochemical analysis of VEGF demonstrated its positive correlation with capsule infiltration, portal vein invasion, and HIF-2α/EPAS1 overexpression, which supported the correlation of HIF-2α/ EPAS1up-regulation with tumor angiogenesis. No apparent correlation was observed between HIF-2α/EPAS1 and capsular formation, presence of cirrhosis, and histological grade.

CONCLUSION: HIF-2α/EPAS1 is expressed in most of HCC with capsular infiltration and portal vein invasion, which indicates a possible role of HIF-2α/EPAS1 in HCC metastasis.

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