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©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 15, 2004; 10(22): 3380-3381
Published online Nov 15, 2004. doi: 10.3748/wjg.v10.i22.3380
Published online Nov 15, 2004. doi: 10.3748/wjg.v10.i22.3380
Effect of 2-(3-carboxy-1-oxopropyl) amino-2-deoxy-D-glucose on human esophageal cancer cell line
Jing Wu, Ai-Qing Wang, Wei-Min Liu, Qun-Ji Xue, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China
Jing Wu, Hong Lu, Yun Zhou, Rui Ji, Department of Gastroenterology and Hepatology, First Teaching Hospital of Lanzhou Medical College, Lanzhou 730000, Gansu Province, China
Liang Qiao, Storr Liver Unit, Westmead Millennium Institute, Department of Gastroenterology and Hepatology, Westmead Hospital, University of Sydney Westmead, NSW 2145, Australia
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Jing Wu, Department of Gastroenterology and Hepatology, First Teaching Hospital of Lanzhou Medical College, Lanzhou 730000, Gansu Province, China. wujing36@163.com
Telephone: +86-931-8619605
Received: April 22, 2004
Revised: April 24, 2004
Accepted: April 29, 2004
Published online: November 15, 2004
Revised: April 24, 2004
Accepted: April 29, 2004
Published online: November 15, 2004
Abstract
AIM: To determine whether 2-(3-carboxy-1-oxopropy1) amino-2-deoxy-D-glucose (COPADG), a derivative of D-amino-glucose, inhibited the growth of human esophageal cancer cell line Eca-109.
METHODS: Effects of COPADG on Eca-109 cells cultured in RPMI 1640 medium were examined by a tetrazolium-based colorimetric assay (MTT assay).
RESULTS: COPADG inhibited the growth of Eca-109 cells in a dose- and time-dependent manner; the maximum inhibition rate was 83.75%.
CONCLUSION: COPADG can directly inhibit the proliferation of Eca-109 cells, which may serve as the experimental evidence for development of new drugs for esophageal cancer therapy.
Keywords: $[Keywords]