Brief Reports
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 15, 2004; 10(22): 3342-3344
Published online Nov 15, 2004. doi: 10.3748/wjg.v10.i22.3342
Helicobacter pylori seroprevalence in patients with lung cancer
Nikiphoros Philippou, Panagiotis Koursarakos, Evgenia Anastasakou, Vasiliki Krietsepi, Stavroula Mavrea, Anastasios Roussos, Dionissia Alepopoulou, Irineos Iliopoulos
Nikiphoros Philippou, Panagiotis Koursarakos, Vasiliki Krietsepi, Anastasios Roussos, Irineos Iliopoulos, 9th Department of Pulmonary Medicine, "SOTIRIA" Chest Diseases Hospital, Athens, Greece
Evgenia Anastasakou, Stavroula Mavrea, Dionissia Alepopoulou, Section of Immunology and Infectious Diseases, "SOTIRIA" Chest Diseases Hospital, Athens, Greece
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Nikiphoros Philippou, 9th Department of Pulmonary Medicine, "SOTIRIA" Chest Diseases Hospital, 152 Mesogion Street, PO Box 11527, Athens, Greece. roumar26@yahoo.com
Telephone: +301-210-8646215 Fax: +301-210-8646215
Received: August 2, 2003
Revised: September 4, 2003
Accepted: September 12, 2003
Published online: November 15, 2004
Abstract

AIM: To assess Helicobacter pylori (H pylori) seroprevalence in a cohort of Greek patients with lung cancer.

METHODS: Seventy-two lung cancer patients (55 males and 17 females, aged 58.2 ± 11.7 years) and 68, age and gender-matched, control subjects were enrolled. All subjects underwent an enzyme-linked immunosorbent assay IgG serologic test for H pylori diagnosis.

RESULTS: A correlation between age and H pylori IgG level was detected for both lung cancer patients (r = 0.42, P = 0.004) and controls (r = 0.44, P = 0.004). Seropositivity for H pylori did not differ significantly between patients with lung cancer and controls (61.1% vs 55.9%, P > 0.05). Concerning the mean serum concentration of IgG antibodies against H pylori, no significant difference between the two groups was detected (32.6 ± 19.1 vs 27.4 ± 18.3 U/mL, P > 0.05).

CONCLUSION: No significant association between H pylori infection and lung cancer was found.

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