Protective effects of tumor necrosis factor &alpha; antibody and ulinastatin on liver ischemic reperfusion in rats

doi:10.3748/wjg.v10.i21.3161

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Nov 1, 2004 (publication date) through Nov 9, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. Nov 1, 2004; 10(21): 3161-3164
Published online Nov 1, 2004. doi: 10.3748/wjg.v10.i21.3161

Protective effects of tumor necrosis factor α antibody and ulinastatin on liver ischemic reperfusion in rats

Yan-Ling Yang, Ji-Peng Li, Xiao-Ping Xu, Ke-Feng Dou, Shu-Qiang Yue, Kai-Zong Li

Yan-Ling Yang, Ji-Peng Li, Ke-Feng Dou, Shu-Qiang Yue, Kai-Zong Li, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China

Xiao-Ping Xu, Department of General Surgery, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, Guangdong Province, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30070741

Correspondence to: Kai-Zong Li, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China. gdwk@fmmu.edu.cn Telephone: +86-29-83375259 Fax: +86-29-83375561

Received: August 26, 2003
Revised: October 20, 2003
Accepted: October 27, 2003
Published online: November 1, 2004

Abstract

AIM: To study the protective effects of tumor necrosis factor α (TNF α ) antibody and ulinastatin on liver ischemic reperfusion in rats.

METHODS: One hundred and twenty male SD rats were randomly divided into four groups: Normal control group, ischemic group, TNFα antibody group and TNFα antibody + ulinastatin group. The animals were killed at 0, 3, 6, 9, 12 h after ischemia for 60 min and followed by reperfusion. Serum alanine aminotransferase (ALT), malondialdehyde (MDA) and liver histopathology were observed.

RESULTS: After ischemic reperfusion, the serum ALT and MDA were remarkably increased, and the hepatic congestion was obvious. Treatment of TNFα antibody and ulinastatin could significantly decrease serum ALT and MDA levels, and relieve hepatic congestion.

CONCLUSION: Ulinastatin and TNFα antibody can suppress the inflammatory reaction induced by hepatic ischemic reperfusion, and have protective effects on rat hepatic ischemic reperfusion injury.

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