Empirical antibiotic treatment with piperacillin-tazobactam in patients with microbiologically-documented biliary tract infections

doi:10.3748/wjg.v10.i15.2281

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 1, 2004; 10(15): 2281-2283
Published online Aug 1, 2004. doi: 10.3748/wjg.v10.i15.2281

Empirical antibiotic treatment with piperacillin-tazobactam in patients with microbiologically-documented biliary tract infections

Gabrio Bassotti, Fabio Chistolini, Francis Sietchiping-Nzepa, Giuseppe de Roberto, Antonio Morelli

Gabrio Bassotti, Fabio Chistolini, Francis Sietchiping-Nzepa, Giuseppe de Roberto, Antonio Morelli, Gastrointestinal and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Gabrio Bassotti,Strada del Cimitero, 2/a, San Marco 06131 Perugia, Italy. gabassot@tin.it

Fax: +39-75-5847570

Received: November 26, 2003
Revised: November 29, 2003
Accepted: January 17, 2004
Published online: August 1, 2004

Abstract

AIM: To report our experience with empiric antimicrobial monotherapy (piperacillin/tazobactam, of which no data are available in such specific circumstances) in microbiologically-documented infections in patients with benign and malignant conditions of the biliary tract.

METHODS: Twenty-three patients, 10 with benign and 13 with malignant conditions affecting the biliary tree and microbiologically-documented infections were recruited and the efficacy of empirical antibiotic therapy was assessed.

RESULTS: The two groups featured similar demographic and clinical data. Overall, the infective episodes were most due to Gram negative agents, more than 60% of such episodes (mostly in malignant conditions) were preceded by invasive instrumental maneuvers. Empirical antibiotic therapy with a single agent (piperacillin/tazobactam) was effective in more than 80% of cases. No deaths were reported following infections.

CONCLUSION: An empiric therapeutic approach with piperacillin/tazobactam is highly effective in biliary tract infections due to benign or malignant conditions.

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