Zhang QX, Ding Y, Li Z, Le XP, Zhang W, Sun L, Shi HR. Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue. World J Gastroenterol 2004; 10(12): 1819-1821 [PMID: 15188514 DOI: 10.3748/wjg.v10.i12.1819]
Corresponding Author of This Article
Professor. Qin-Xian Zhang, Molecular Cell Biology Research Center, Medical College of Zhengzhou University, 40 Daxue Lu, Zhengzhou 450052, Henan Province, China. qxz53@zzu.edu.cn
Article-Type of This Article
Brief Reports
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jun 15, 2004 (publication date) through Oct 30, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Zhang QX, Ding Y, Li Z, Le XP, Zhang W, Sun L, Shi HR. Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue. World J Gastroenterol 2004; 10(12): 1819-1821 [PMID: 15188514 DOI: 10.3748/wjg.v10.i12.1819]
World J Gastroenterol. Jun 15, 2004; 10(12): 1819-1821 Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1819
Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue
Qin-Xian Zhang, Yi Ding, Zhuo Li, Xiao-Ping Le, Wei Zhang, Ling Sun, Hui-Rong Shi
Qin-Xian Zhang, Yi Ding, Xiao-Ping Le, Wei Zhang, Molecular Cell Biology Research Center, Medical College of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Zhuo Li, Ling Sun, Hui-Rong Shi, Henan Key Laboratory of Molecular Medicine, Zhengzhou 450052, Henan Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 39170440
Correspondence to: Professor. Qin-Xian Zhang, Molecular Cell Biology Research Center, Medical College of Zhengzhou University, 40 Daxue Lu, Zhengzhou 450052, Henan Province, China. qxz53@zzu.edu.cn
Telephone: +86-371-6977002
Received: August 5, 2003 Revised: October 15, 2003 Accepted: October 22, 2003 Published online: June 15, 2004
Abstract
AIM: To study the alteration of nuclear matrix proteins (NMPs) in gastric cancer.
METHODS: The NMPs extracted from 22 cases of gastric cancer and normal gastric tissues were investigated by SDS-PAGE technique and the data were analyzed using Genetools analysis software.
RESULTS: Compared with normal gastric tissue, the expression of 30 ku and 28 ku NMPs in gastric cancer decreased significantly (P = 0.002, P = 0.001, P < 0.05). No significant difference was found in the expression of the two NMPs between the various differentiated grades (P = 0.947, P = 0.356) and clinical stages of gastric cancer (P = 0.920, P = 0.243, P > 0.05).
CONCLUSION: The results suggested that the alteration of NMPs in gastric cancer occurred at the early stage of gastric cancer development.
