| For: | Kong GM, Tao WH, Diao YL, Fang PH, Wang JJ, Bo P, Qian F. Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway. World J Gastroenterol 2016; 22(11): 3186-3195 [PMID: 27003995 DOI: 10.3748/wjg.v22.i11.3186] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v22/i11/3186.htm |
| Number | Citing Articles |
| 1 |
Subhalaxmi Roy, Bijoy Kumar Mishra, Manasa Shastri Pattnaik, Sushree Suparna Mahapatra. Health Benefits of Honey and Propolis - Scientific Evidence and Medicinal Uses. Food Science and Nutrition 2025; 13 doi: 10.5772/intechopen.1007426
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| 2 |
Joe Rizkallah, Nicole Charbel, Abdallah Yassine, Amal El Masri, Chris Raffoul, Omar El Sardouk, Malak Ghezzawi, Therese Abou Nasr, Firas Kreidieh. Melittin-Based Nanoparticles for Cancer Therapy: Mechanisms, Applications, and Future Perspectives. Pharmaceutics 2025; 17(8) doi: 10.3390/pharmaceutics17081019
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| 3 |
Amit Kumar Tripathi, Jamboor K. Vishwanatha. Role of Anti-Cancer Peptides as Immunomodulatory Agents: Potential and Design Strategy. Pharmaceutics 2022; 14(12) doi: 10.3390/pharmaceutics14122686
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| 4 |
Fahimeh Salehi, Hossein Behboudi, Gholamreza Kavoosi, Sussan K. Ardestani. Monitoring ZEO apoptotic potential in 2D and 3D cell cultures and associated spectroscopic evidence on mode of interaction with DNA. Scientific Reports 2017; 7(1) doi: 10.1038/s41598-017-02633-z
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| 5 |
Charbel Chahla, Mohamad Rima, Charbel Mouawad, Rabih Roufayel, Hervé Kovacic, Dany El Obeid, Jean-Marc Sabatier, José Luis, Ziad Fajloun, Bilal El-Waly. Effect of Apis mellifera syriaca Bee Venom on Glioblastoma Cancer: In Vitro and In Vivo Studies. Molecules 2024; 29(16) doi: 10.3390/molecules29163950
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| 6 |
Yuezhihong Xiong, Huili Cai, Siyu Jia, Boya Gong, Kairong Hou, Hongyan Wu, Haidan Chen. Nanocarrier-Enabled Melittin Therapy: Mechanistic Advances, Therapeutic Applications, and Translational Challenges. International Journal of Nanomedicine 2026; doi: 10.2147/IJN.S599827
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| 7 |
Guohua Hou, Yuan Li, Qimeng Wang, Huijuan Zhang, Shuang Liang, Bin Liu, Wenbiao Shi. iRGD-grafted N-trimethyl chitosan-coated protein nanotubes enhanced the anticancer efficacy of curcumin and melittin. International Journal of Biological Macromolecules 2022; 222 doi: 10.1016/j.ijbiomac.2022.09.171
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| 8 |
Hongzhi Qiao, Dong Fang, Lei Zhang, Xiaochen Gu, Yin Lu, Minjie Sun, Chunmeng Sun, Qineng Ping, Junsong Li, Zhipeng Chen, Jun Chen, Lihong Hu, Liuqing Di. Nanostructured Peptidotoxins as Natural Pro-Oxidants Induced Cancer Cell Death via Amplification of Oxidative Stress. ACS Applied Materials & Interfaces 2018; 10(5) doi: 10.1021/acsami.7b18809
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| 9 |
Tomasz Kowalczyk, Martyna Muskała, Janusz Piekarski, Maciej Kowalski, Marek Staszewski, Belma Konuklugil, Patricia Rijo, Przemysław Sitarek. Therapeutic Promise and Biotechnological Prospects of Dendroaspis polylepis Venom Proteins: Mambalgins, Fasciculins, and Dendrotoxins. International Journal of Molecular Sciences 2025; 26(20) doi: 10.3390/ijms26209895
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| 10 |
Zidan Jin, Jie Yao, Nianlin Xie, Libo Cai, Shuai Qi, Zhan Zhang, Bai Li. Melittin Constrains the Expression of Identified Key Genes Associated with Bladder Cancer. Journal of Immunology Research 2018; 2018 doi: 10.1155/2018/5038172
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| 11 |
Yanwen Li, Xingnan Yue, Shuo Wang, Pengyue Li, Man Zhang, Kuokui Song, Xiulan Huang, Zhiyong Li. Protective Effect of Trillium tschonoskii Maxim Components Against Glutamate-Induced SH-SY5Y Cells Damage Through Regulating Apoptosis. Dose-Response 2023; 21(2) doi: 10.1177/15593258231169585
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| 12 |
Xuefeng Duan, Haoyang Zou, Jiazhen Yang, Shixian Liu, Tianmin Xu, Jianxun Ding. Melittin-incorporated nanomedicines for enhanced cancer immunotherapy. Journal of Controlled Release 2024; 375 doi: 10.1016/j.jconrel.2024.08.047
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| 13 |
Qian-Qian Li, Pu-Guang Chen, Zhi-Wen Hu, Yuan Cao, Liang-Xiao Chen, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei Li. Selective inhibition of cancer cells by enzyme-induced gain of function of phosphorylated melittin analogues. Chem. Sci. 2017; 8(11) doi: 10.1039/C7SC03217J
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| 14 |
Mostafa Akbarzadeh-Khiavi, Mitra Torabi, Amir-Hossein Olfati, Leila Rahbarnia, Azam Safary. Bio-nano scale modifications of melittin for improving therapeutic efficacy. Expert Opinion on Biological Therapy 2022; 22(7) doi: 10.1080/14712598.2022.2088277
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| 15 |
Jinxia Qi, Yuxin Liu, Hejie Xu, Tiantian Xue, Yu Su, Zhenkun Lin. Anti-cancer effect of melittin-Au25(MHA)18 complexes on human cervical cancer HeLa cells. Journal of Drug Delivery Science and Technology 2022; 68 doi: 10.1016/j.jddst.2021.103078
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| 16 |
Rasha Abdeen Refaei, Ahmed M. Refaat, Amany M. Hamed, Noha A. R. Fouda, Zeyad Elsayed Eldeeb Mohana, Rawia M. Ibrahim, Ereen Kondos Naeem, Gehad S. Mokhtar, Pierre E. Mehanny, Sherine Nabil Mohammed Fawzy, Nagwa M. El-Sawi, Elsayed Eldeeb Mehana Hamouda, Nadia S. Mahrous. Nano-Melittin Attenuates Zearalenone-Induced Ovarian Toxicity by Modulating the Inflammatory–Apoptotic–Steroidogenic Axis in Rats. Physiologia 2026; 6(1) doi: 10.3390/physiologia6010020
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| 17 |
Sirikwan Sangboonruang, Kuntida Kitidee, Panuwan Chantawannakul, Khajornsak Tragoolpua, Yingmanee Tragoolpua. Melittin from Apis florea Venom as a Promising Therapeutic Agent for Skin Cancer Treatment. Antibiotics 2020; 9(8) doi: 10.3390/antibiotics9080517
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| 18 |
Sara Ahlgren, Karin Reijmar, Katarina Edwards. Targeting lipodisks enable selective delivery of anticancer peptides to tumor cells. Nanomedicine: Nanotechnology, Biology and Medicine 2017; 13(7) doi: 10.1016/j.nano.2017.06.020
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| 19 |
Lin Ang, Eunhye Song, Hye Won Lee, Myeong Soo Lee. Bee Products and Their Applications in the Food and Pharmaceutical Industries. 2022; doi: 10.1016/B978-0-323-85400-9.00001-0
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| 20 |
Aeyung Kim, Seo-Young Lee, Bu-Yeo Kim, Sun-Ku Chung. Elimination of Teratogenic Human Induced Pluripotent Stem Cells by Bee Venom via Calcium-Calpain Pathway. International Journal of Molecular Sciences 2020; 21(9) doi: 10.3390/ijms21093265
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| 21 |
Qi Liu, Lei Wang, Dongxia He, Yuewei Wu, Xian Liu, Yahan Yang, Zhizhi Chen, Zhan Dong, Ying Luo, Yuzhu Song. Application Value of Antimicrobial Peptides in Gastrointestinal Tumors. International Journal of Molecular Sciences 2023; 24(23) doi: 10.3390/ijms242316718
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| 22 |
Hai-Qian Zhang, Chengbiao Sun, Na Xu, Wensen Liu. The current landscape of the antimicrobial peptide melittin and its therapeutic potential. Frontiers in Immunology 2024; 15 doi: 10.3389/fimmu.2024.1326033
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| 23 |
R. Sindhu, H.K. Manonmani. l-asparaginase induces intrinsic mitochondrial-mediated apoptosis in human gastric adenocarcinoma cells and impedes tumor progression. Biochemical and Biophysical Research Communications 2018; 503(4) doi: 10.1016/j.bbrc.2018.06.167
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| 24 |
Samia E. El-Didamony, Mohamed H. Kalaba, Mohamed H. Sharaf, Esmail M. El-Fakharany, Ali Osman, Mahmoud Sitohy, Basel Sitohy. Melittin alcalase-hydrolysate: a novel chemically characterized multifunctional bioagent; antibacterial, anti-biofilm and anticancer. Frontiers in Microbiology 2024; 15 doi: 10.3389/fmicb.2024.1419917
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| 25 |
Adam Majchrzak, Filip Lewandowski, Rafał Hrynkiewicz, Agata Poniewierska-Baran, Dominika Bębnowska, Paulina Niedźwiedzka-Rystwej. Granzyme B and melittin in cancer immunotherapy: molecular mechanisms and therapeutic perspectives in head and neck cancers. Frontiers in Immunology 2025; 16 doi: 10.3389/fimmu.2025.1628014
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| 26 |
Suman Jangir, Varalakshmi Kilingar Nadumane. Anticancer Therapeutics from Insect-derived Compounds. Current Cancer Therapy Reviews 2025; 21(6) doi: 10.2174/0115733947311327240802115914
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| 27 |
Mohamed A. Alfaleh, Omar Fahmy, Mohammed W. Al-Rabia, Mohammed A. S. Abourehab, Osama A. A. Ahmed, Usama A. Fahmy, Helal H. Alsulimani, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Bander M. Aldhabi, Awaad S. Alharbi, Nabil A. Alhakamy. RETRACTED ARTICLE: Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer. Scientific Reports 2022; 12(1) doi: 10.1038/s41598-022-24151-3
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| 28 |
Asmaa M. Shehata, Hala F. Aref, Mohamed Y. Mahmoud, Alaa F. Bakr, Maha A. Salem, Eiman M. El-Saied. PLGA nanoparticles provide a safe delivery system for bee venom and melittin to alleviate their hepatotoxic effects in mice. Toxicon 2025; 267 doi: 10.1016/j.toxicon.2025.108564
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| 29 |
Perihan Mutlu Erdoğan, Funda Bilgili-Tetikoğlu, Selcen Çelik-Uzuner, Oktay Yıldız, Sevgi Kolayli, Dimitris Mossialos. Therapeutic Bioactivity Exerted by the Apis mellifera Bee Venom and Its Major Protein Melittin: A Scoping Review. Molecules 2025; 30(19) doi: 10.3390/molecules30194003
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| 30 |
Cui-cui Liu, Ding-jun Hao, Qian Zhang, Jing An, Jing-jing Zhao, Bo Chen, Ling-ling Zhang, Hao Yang. Application of bee venom and its main constituent melittin for cancer treatment. Cancer Chemotherapy and Pharmacology 2016; 78(6) doi: 10.1007/s00280-016-3160-1
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| 31 |
Seo-Na Chang, Se-Hee Kim, Hyun Ju Kim, Yeon Jae Jeong, Kyu Chan Lee. In Vitro and In Vivo Investigation of the Radiation-Sensitizing Effects of Melittin in Breast Cancer Cells. International Journal of Peptide Research and Therapeutics 2022; 28(1) doi: 10.1007/s10989-021-10313-w
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| 32 |
Diana Harfmann, Adrian Florea. Experimental envenomation with honeybee venom melittin and phospholipase A2 induced multiple ultrastructural changes in adrenocortical mitochondria. Toxicon 2023; 229 doi: 10.1016/j.toxicon.2023.107136
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| 33 |
Rucheng Yan, Kejia Zhang, Jiayu Chen, Yuanquan Pan, Haifeng Wang. Melittin enhances PD-L1 blockade in prostate cancer by inhibiting M2 macrophage polarization and recruitment. World Journal of Surgical Oncology 2026; 24(1) doi: 10.1186/s12957-026-04305-7
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| 34 |
Chufan Wang, Fengrui Zhang, Haobo Tang, Zhengchan Su, Yufei Duan, Wei Feng, Xiaoning Lin, E. Chen, Xiumin Wang, Lei Ren. Harnessing multifunctional HBc virus-like particles for safe and effective delivery of melittin in cancer therapy. Nanomedicine 2025; 20(14) doi: 10.1080/17435889.2025.2528591
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| 35 |
Wen-bin Zhu, Fu-jun Tian, Li-qian Liu. Chikusetsu (CHI) triggers mitochondria-regulated apoptosis in human prostate cancer via reactive oxygen species (ROS) production. Biomedicine & Pharmacotherapy 2017; 90 doi: 10.1016/j.biopha.2017.03.050
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| 36 |
Shantanu Guha, Ryan P. Ferrie, Jenisha Ghimire, Cristina R. Ventura, Eric Wu, Leisheng Sun, Sarah Y. Kim, Gregory R. Wiedman, Kalina Hristova, Wimley C. Wimley. Applications and evolution of melittin, the quintessential membrane active peptide. Biochemical Pharmacology 2021; 193 doi: 10.1016/j.bcp.2021.114769
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| 37 |
Haet Nim Lim, Seung Bae Baek, Hye Jin Jung. Bee Venom and Its Peptide Component Melittin Suppress Growth and Migration of Melanoma Cells via Inhibition of PI3K/AKT/mTOR and MAPK Pathways. Molecules 2019; 24(5) doi: 10.3390/molecules24050929
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| 38 |
Amjad Ullah, Fahad Mohammed Aldakheel, Syed Ishtiaq Anjum, Ghulam Raza, Saeed Ahmad Khan, Ivana Tlak Gajger. Pharmacological properties and therapeutic potential of honey bee venom. Saudi Pharmaceutical Journal 2023; 31(1) doi: 10.1016/j.jsps.2022.11.008
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| 39 |
Grzegorz Król, Angelika Mańkowska, Paulina Paprocka, Małgorzata Sidewicz, Jakub Spałek, Sławomir Okła, Ewelina Piktel, Robert Bucki. Functional reprogramming of melittin by Pluronic® F-127 enables anticancer selectivity with attenuated hemolytic activity. Frontiers in Oncology 2026; 16 doi: 10.3389/fonc.2026.1823622
|
| 40 |
Xuan Li, Sen Zhu, Zheng Li, Yu-Qi Meng, Su-Jie Huang, Qi-Yao Yu, Bin Li. Melittin induces ferroptosis and ER stress-CHOP-mediated apoptosis in A549 cells. Free Radical Research 2022; 56(5-6) doi: 10.1080/10715762.2022.2131551
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| 41 |
Qi Li, Shiyan Fu, Anni Zhang, Wenrun Li, Li Shen, Feng Huang, Xiaoyu Yang, Yonghong Ran, Yazhen Zhao, Longfei Tan, Jinshan Xu, Yuhui Hao. Gradually cleared Gd-MOF@AuPt/Melittin nanocomposite for augmented radiotherapy by inducing apoptosis and ferroptosis. Journal of Drug Delivery Science and Technology 2026; 123 doi: 10.1016/j.jddst.2026.108462
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| 42 |
Ruiyin Guo, Xuewen Chen, Tienthanh Nguyen, Jinwei Chai, Yahua Gao, Jiena Wu, Jinqiao Li, Mohamed A. Abdel-Rahman, Xin Chen, Xueqing Xu. The Strong Anti-Tumor Effect of Smp24 in Lung Adenocarcinoma A549 Cells Depends on Its Induction of Mitochondrial Dysfunctions and ROS Accumulation. Toxins 2022; 14(9) doi: 10.3390/toxins14090590
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| 43 |
Rui Ma, Ravikiran Mahadevappa, Hang Fai Kwok. Venom-based peptide therapy: insights into anti-cancer mechanism. Oncotarget 2017; 8(59) doi: 10.18632/oncotarget.21740
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| 44 |
Maria Carpena, Bernabe Nuñez-Estevez, Anton Soria-Lopez, Jesus Simal-Gandara. Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications. Nutrients 2020; 12(11) doi: 10.3390/nu12113360
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| 45 |
Seog Young Kang, Dongwon Hwang, Soyoung Shin, Jinju Park, Myoungchan Kim, MD. Hasanur Rahman, Md. Ataur Rahman, Seong-Gyu Ko, Bonglee Kim. Potential of Bioactive Food Components against Gastric Cancer: Insights into Molecular Mechanism and Therapeutic Targets. Cancers 2021; 13(18) doi: 10.3390/cancers13184502
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| 46 |
Jie Yao, Zhan Zhang, Sheng Li, Bai Li, Xing‐Huan Wang. Melittin inhibits proliferation, migration and invasion of bladder cancer cells by regulating key genes based on bioinformatics and experimental assays. Journal of Cellular and Molecular Medicine 2020; 24(1) doi: 10.1111/jcmm.14775
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| 47 |
Shafiul Haque, Arif Hussain, Hemant Joshi, Ujjawal Sharma, Bunty Sharma, Diwakar Aggarwal, Isha Rani, Seema Ramniwas, Madhu Gupta, Hardeep Singh Tuli. Melittin: a possible regulator of cancer proliferation in preclinical cell culture and animal models. Journal of Cancer Research and Clinical Oncology 2023; 149(19) doi: 10.1007/s00432-023-05458-8
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| 48 |
Long Lv, Nan Yang, Youhong Cao, Junqiang Dang, Likun Cheng, Mohamed A. El‐Sheikh, Yun Zhang. d‐Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells. Journal of Biochemical and Molecular Toxicology 2021; 35(5) doi: 10.1002/jbt.22746
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| 49 |
Danijela D. Nikodijević, Jovana V. Jovankić, Nikola M. Radenković, Danijela M. Cvetković, Ana M. Podolski-Renić, Milena G. Milutinović. Potential of Melittin to induce apoptosis and overcome multidrug resistance in human colon cancer cell line. Toxin Reviews 2024; 43(2) doi: 10.1080/15569543.2024.2317294
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| 50 |
Preeti Solanki, Mohini Rana, Karnail Choudhary, Vishal Ahuja, Vinay Kumar, Anuradha Tyagi. The Anti-Leukemic Potential of Bee Venom. International Journal of General Medicine 2025; doi: 10.2147/IJGM.S560153
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| 51 |
Xinjing Wang, Jing Xie, Xiongxiong Lu, Hongzhe Li, Chenlei Wen, Zhen Huo, Junjie Xie, Minmin Shi, Xiaomei Tang, Hao Chen, Chenghong Peng, Yuan Fang, Xiaxing Deng, Baiyong Shen. Melittin inhibits tumor growth and decreases resistance to gemcitabine by downregulating cholesterol pathway gene CLU in pancreatic ductal adenocarcinoma. Cancer Letters 2017; 399 doi: 10.1016/j.canlet.2017.04.012
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| 52 |
Islam Rady, Imtiaz A. Siddiqui, Mohamad Rady, Hasan Mukhtar. Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy. Cancer Letters 2017; 402 doi: 10.1016/j.canlet.2017.05.010
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| 53 |
Lucas Fornari Laurindo, Enzo Pereira de Lima, Lívia Fornari Laurindo, Victória Dogani Rodrigues, Eduardo Federighi Baisi Chagas, Ricardo de Alvares Goulart, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Karina Torres Pomini, Rose Eli Grassi Rici, Durvanei Augusto Maria, Rosa Direito, Sandra Maria Barbalho. The therapeutic potential of bee venom-derived Apamin and Melittin conjugates in cancer treatment: A systematic review. Pharmacological Research 2024; 209 doi: 10.1016/j.phrs.2024.107430
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| 54 |
Sibel Kaymak, Nilüfer Vural, Oğuz Yüce, Salih Mollahaliloğlu. DOĞANIN ŞİFASI: ARI ZEHRİNİN SAĞLIK ÜZERİNDEKİ ETKİLERİ VE UYGULAMALARI. Uludağ Arıcılık Dergisi 2024; 24(2) doi: 10.31467/uluaricilik.1512321
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| 55 |
Ayşegül Varol, Serap Sezen, Dilhan Evcimen, Atefeh Zarepour, Gönül Ulus, Ali Zarrabi, Gamal Badr, Sevgi Durna Daştan, Asya Gülistan Orbayoğlu, Zeliha Selamoğlu, Mehmet Varol. Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments. Toxin Reviews 2022; 41(4) doi: 10.1080/15569543.2021.2024576
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| 56 |
Jinxia Qi, Yonghui Chen, Tiantian Xue, Yue Lin, Shiyuan Huang, Shuyan Cao, Xiaona Wang, Yu Su, Zhenkun Lin. Graphene oxide-based magnetic nanocomposites for the delivery of melittin to cervical cancer HeLa cells. Nanotechnology 2020; 31(6) doi: 10.1088/1361-6528/ab5084
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| 57 |
Dan Sun, Shanshan Li, Haiqin Huang, Lixing Xu. Neurotoxicity of melittin: Role of mitochondrial oxidative phosphorylation system in synaptic plasticity dysfunction. Toxicology 2023; doi: 10.1016/j.tox.2023.153628
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| 58 |
Yanyan Li, Shuyao Ruan, Zhi Wang, Nianping Feng, Yongtai Zhang. Hyaluronic Acid Coating Reduces the Leakage of Melittin Encapsulated in Liposomes and Increases Targeted Delivery to Melanoma Cells. Pharmaceutics 2021; 13(8) doi: 10.3390/pharmaceutics13081235
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| 59 |
Xiaoxia Yang, Cui Hua, Lin Lin, Zhao Ganting. Antimicrobial peptides as potential therapy for gastrointestinal cancers. Naunyn-Schmiedeberg's Archives of Pharmacology 2023; 396(11) doi: 10.1007/s00210-023-02536-z
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| 60 |
Luís Silva, Sajid Ali, Lars Gedda, Víctor Agmo Hernández, Katarina Edwards. Development and in vitro evaluation of lipodisks optimized for co-delivery of chemotherapeutic drugs and membranolytic anticancer peptides. Journal of Colloid and Interface Science 2025; 699 doi: 10.1016/j.jcis.2025.138173
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| 61 |
Zahra Setayesh-Mehr, Leila Vafadar Ghasemi. HL-10 Peptide as a Potential Therapeutic Agent for Cervical SiHa Cancer Cells. Jentashapir Journal of Cellular and Molecular Biology 2025; 16(1) doi: 10.5812/jjcmb-157039
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| 62 |
Abdullah K. Alshememry, Mohd Abul Kalam, Abdullah A. Alshehri, Fahad A. Almughem, Sulaiman S. Alhudaithi, Raisuddin Ali, Meshari M. Alamer, Hamad S. Alzeer, Ali A. Alamer, Amjad N. Alotaibi, Abeer H. Alomair, Meshal K. Alnefaie, Essam A. Tawfik, Ziyad Binkhathlan. Enhanced delivery of Melittin via PEGylated PLGA nanoparticles: formulation, characterization, and in vitro evaluation. Journal of Drug Delivery Science and Technology 2025; 110 doi: 10.1016/j.jddst.2025.107101
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| 63 |
Zhaoying Fu, Xiaodong Han, Juan Du, Xiaoxiao Han, Weipeng Liu, Shumei Shao, Xiaobin Liu. Euphorbia lunulata extract acts on multidrug resistant gastric cancer cells to inhibit cell proliferation, migration and invasion, arrest cell cycle progression, and induce apoptosis. Journal of Ethnopharmacology 2018; 212 doi: 10.1016/j.jep.2017.08.014
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| 64 |
Qiwu Zhao, Haoran Feng, Zheyu Yang, Juyong Liang, Zhijian Jin, Lingxie Chen, Ling Zhan, Ming Xuan, Jiqi Yan, Jie Kuang, Xi Cheng, Ren Zhao, Weihua Qiu. The central role of a two‐way positive feedback pathway in molecular targeted therapies‐mediated pyroptosis in anaplastic thyroid cancer. Clinical and Translational Medicine 2022; 12(2) doi: 10.1002/ctm2.727
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| 65 |
Marcos Roberto de Oliveira. Melittin-induced modulation of mitochondrial physiology: Beyond the antitumoral actions. Toxicon 2025; 266 doi: 10.1016/j.toxicon.2025.108555
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| 66 |
Xuan Li, Zheng Li, Yu-Qi Meng, Hui Qiao, Ke-Rong Zhai, Zhen-Qing Li, Shi-Lin Wei, Bin Li. Melittin kills A549 cells by targeting mitochondria and blocking mitophagy flux. Redox Report 2023; 28(1) doi: 10.1080/13510002.2023.2284517
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| 67 |
Theerthu Azhamuthu, Suresh Kathiresan, Ilanchitchenni Senkuttuvan, Nihal Ahamed Abulkalam Asath, Pugazhendhi Ravichandran, Rajeswari Vasu. Usnic acid alleviates inflammatory responses and induces apoptotic signaling through inhibiting NF‐ĸB expressions in human oral carcinoma cells. Cell Biochemistry and Function 2024; 42(4) doi: 10.1002/cbf.4074
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| 68 |
SUFANG ZHANG, XIANG LV, LI LI, YINGBIN LUO, HUINAN XIANG, LIXIN WANG, YAN LI. Melittin inhibited glycolysis and induced cell apoptosis in cisplatinresistant lung adenocarcinoma cells via TRIM8. BIOCELL 2021; 45(1) doi: 10.32604/biocell.2021.013636
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| 69 |
Kemal Ertilav, Mustafa Nazıroğlu. Honey bee venom melittin increases the oxidant activity of cisplatin and kills human glioblastoma cells by stimulating the TRPM2 channel. Toxicon 2023; 222 doi: 10.1016/j.toxicon.2022.106993
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| 70 |
Maksymilian Stela, Michał Ceremuga, Natalia Cichon, Tomasz Poplawski, Marcin Podogrocki, Leslaw Gorniak, Michał Bijak. Pro-Apoptotic and Cytotoxic Effects of Melittin on HL-60 Acute Promyelocytic Leukemia Cells: Implications for Retinoid-Independent Therapy. Molecules 2025; 30(20) doi: 10.3390/molecules30204093
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| 71 |
Elaheh Jamasbi, Sasidharan S. Lucky, Wenyi Li, Mohammed Akhter Hossain, Ponnampalam Gopalakrishnakone, Frances Separovic. Effect of dimerized melittin on gastric cancer cells and antibacterial activity. Amino Acids 2018; 50(8) doi: 10.1007/s00726-018-2587-6
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| 72 |
Francesco Colella, Giovanni Scillitani, Ciro Leonardo Pierri. Sweet as honey, bitter as bile: Mitochondriotoxic peptides and other therapeutic proteins isolated from animal tissues, for dealing with mitochondrial apoptosis. Toxicology 2021; 447 doi: 10.1016/j.tox.2020.152612
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| 73 |
Usama A. Fahmy, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Nabil A. Alhakamy, Osama A. A. Ahmed, Mohamed F. Radwan, Basma G. Eid, Shaban R. M. Sayed, Gamal A. El Sherbiny, Walaa Abualsunun. Potentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells. Drug Delivery 2022; 29(1) doi: 10.1080/10717544.2022.2072544
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| 74 |
Zohreh Jafari, Sahar Sadeghi, Mahsa Mirzarazi Dehaghi, Ashkan Bigham, Shokouh Honarmand, Afsaneh Tavasoli, Mostafa Haji Molla Hoseini, Rajender S. Varma. Immunomodulatory activities and biomedical applications of melittin and its recent advances. Archiv der Pharmazie 2024; 357(4) doi: 10.1002/ardp.202300569
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| 75 |
Peticha Tanprasert, Sirikan Limpakan, Siriporn C. Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn. Targeting mitochondria as a therapeutic anti-gastric cancer approach. Apoptosis 2022; 27(3-4) doi: 10.1007/s10495-022-01709-0
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| 76 |
Mengyun Ke, Jian Dong, Yue Wang, Jia Zhang, Mei Zhang, Zheng Wu, Yi Lv, Rongqian Wu. MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells. The International Journal of Biochemistry & Cell Biology 2018; 101 doi: 10.1016/j.biocel.2018.05.013
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| 77 |
Jia‐Ru Wang, Gui‐Nan Shen, Ying‐Hua Luo, Xian‐Ji Piao, Meng Shen, Chang Liu, Yue Wang, Ling‐Qi Meng, Yi Zhang, Hao Wang, Jin‐Qian Li, Wan‐Ting Xu, Yang Liu, Hu‐Nan Sun, Ying‐Hao Han, Mei‐Hua Jin, Long‐Kui Cao, Cheng‐Hao Jin. The compound 2‐(naphthalene‐2‐thio)‐5,8‐dimethoxy‐1,4‐naphthoquinone induces apoptosis via reactive oxygen species‐regulated mitogen‐activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gastric cancer cells. Drug Development Research 2018; 79(6) doi: 10.1002/ddr.21442
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| 78 |
Jye-Yu Huang, Shu-Fen Peng, Fu-Shin Chueh, Po-Yuan Chen, Yi-Ping Huang, Wen-Wen Huang, Jing-Gung Chung. Melittin suppresses epithelial–mesenchymal transition and metastasis in human gastric cancer AGS cells via regulating Wnt/BMP associated pathway. Bioscience, Biotechnology, and Biochemistry 2021; 85(11) doi: 10.1093/bbb/zbab153
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