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For: Annaházi A, Róka R, Rosztóczy A, Wittmann T. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol 2014; 20(20): 6031-6043 [PMID: 24876726 DOI: 10.3748/wjg.v20.i20.6031]
URL: https://www.wjgnet.com/1007-9327/full/v20/i20/6031.htm
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Number Citing Articles
1
Esther Colomier, Joost Algera, Chloé Melchior. Pharmacological Therapies and Their Clinical Targets in Irritable Bowel Syndrome With Diarrhea. Frontiers in Pharmacology 2021; 11 doi: 10.3389/fphar.2020.629026
2
Syed Kashif, Rema Razdan, Ramanaiah Illuri. Potential of phloroglucinol to improve erectile dysfunction associated with streptozotocin-induced diabetes in rats. Journal of Integrative Medicine 2019; 17(4) doi: 10.1016/j.joim.2019.04.002
3
Xiao-Lin Wang, Jian-Ning Zhou, Li Ren, Xiao-Li Pan, Hong-Yu Ren, Jun Liu. Improvement of Quality of Nonanesthetic Colonoscopy by Preoperative Administration of Pinaverium Bromide. Chinese Medical Journal 2017; 130(6) doi: 10.4103/0366-6999.201597
4
Ahmed H. Naggar, Ahmed Kotb, Ahmed A. Gahlan, Mahmoud H. Mahross, Abd El-Aziz Y. El-Sayed, Adel A. Abdelwahab. Graphite Studded with Facile-Synthesized Cu2O Nanoparticle-Based Cubes as a Novel Electrochemical Sensor for Highly Sensitive Voltametric Determination of Mebeverine Hydrochloride. Chemosensors 2021; 9(2) doi: 10.3390/chemosensors9020035
5
Mudassir Alam, Kashif Abbas, Muskan Khan, Rakshit Singh Saini, Mohd Faraz. Irritable Bowel Syndrome: Clinical Manifestations, Pathological Insights, Diagnostic Methods and Effective Management Strategies. SN Comprehensive Clinical Medicine 2026; 8(1) doi: 10.1007/s42399-026-02317-8
6
Mihaela Stoyanova, Miglena Milusheva, Vera Gledacheva, Mina Todorova, Nikoleta Kircheva, Silvia Angelova, Iliyana Stefanova, Mina Pencheva, Bela Vasileva, Kamelia Hristova-Panusheva, Natalia Krasteva, George Miloshev, Yulian Tumbarski, Milena Georgieva, Stoyanka Nikolova. Silver Nanoparticles with Mebeverine in IBS Treatment: DFT Analysis, Spasmolytic, and Anti-Inflammatory Effects. Pharmaceutics 2025; 17(5) doi: 10.3390/pharmaceutics17050561
7
Magnus Simrén, Jan Tack. New treatments and therapeutic targets for IBS and other functional bowel disorders. Nature Reviews Gastroenterology & Hepatology 2018; 15(10) doi: 10.1038/s41575-018-0034-5
8
Simona Codruta Heghes, Oliviu Vostinaru, Lucia Maria Rus, Cristina Mogosan, Cristina Adela Iuga, Lorena Filip. Antispasmodic Effect of Essential Oils and Their Constituents: A Review. Molecules 2019; 24(9) doi: 10.3390/molecules24091675
9
Biswanath Dinda. Pharmacology and Applications of Naturally Occurring Iridoids. 2019;  doi: 10.1007/978-3-030-05575-2_5
10
Biplab Rajbanshi, Koyeli Das, Debadrita Roy, Subhadeep Saha, Mahendra Nath Roy. Exploring 2:1 inclusion complexes of cyclodextrins and antispasmodics, Alverine citrate for enhancing bioavailability and sustained dischargement. Journal of Molecular Liquids 2023; 370 doi: 10.1016/j.molliq.2022.121036
11
Beatrix Pfanzagl, Victor F. Zevallos, Detlef Schuppan, Roswitha Pfragner, Erika Jensen-Jarolim. Histamine causes influx via T-type voltage-gated calcium channels in an enterochromaffin tumor cell line: potential therapeutic target in adverse food reactions. American Journal of Physiology-Gastrointestinal and Liver Physiology 2019; 316(2) doi: 10.1152/ajpgi.00261.2018
12
Azza A. Hasan, Rasha M. Samir, Samir S. Abu-Zaid, Amr S. Abu Lila. Revitalizing the local anesthetic effect of Mebeverine hydrochloride via encapsulation within ethosomal vesicular system. Colloids and Surfaces B: Biointerfaces 2020; 194 doi: 10.1016/j.colsurfb.2020.111208
13
Abdalsalam Kmail. Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds. Open Life Sciences 2024; 19(1) doi: 10.1515/biol-2022-0857
14
Lauren Stemboroski, Ron Schey. Treating Chronic Abdominal Pain in Patients with Chronic Abdominal Pain and/or Irritable Bowel Syndrome. Gastroenterology Clinics of North America 2020; 49(3) doi: 10.1016/j.gtc.2020.05.001
15
Yahong Chen, Xiaohong Wang, Haifeng Zhai, Yanling Zhang, Jianmei Huang. Identification of Potential Human Ryanodine Receptor 1 Agonists and Molecular Mechanisms of Natural Small-Molecule Phenols as Anxiolytics. ACS Omega 2021; 6(44) doi: 10.1021/acsomega.1c04468
16
Toluwanimi I. Atewogbola, Frances A. Davis, Aiden B. De Witt, Sahar Shekoohi, Alan D. Kaye. Modern Approaches to Chronic Pain: Non-Opioid Pharmacologic Strategies. 2026;  doi: 10.1007/978-3-032-33002-4_4
17
Kelly Woo, Andrew Padalhin. Photobiomodulation and its potential in treating irritable bowel syndrome. Medical Lasers 2025; 14(2) doi: 10.25289/ML.25.011
18
Sagar Suman Panda, Venkata Varaha Ravi Kumar Bera, Padmalaya Sahoo, Biswajit Sahu. Quantitative estimation of mebeverine hydrochloride in sustained-release dosage form using an analytical lifecycle management oriented stability-indicating LC method. Journal of Liquid Chromatography & Related Technologies 2018; 41(10) doi: 10.1080/10826076.2018.1500376
19
Susan Lucak, Lin Chang, Albena Halpert, Lucinda A. Harris. Current and emergent pharmacologic treatments for irritable bowel syndrome with diarrhea: evidence-based treatment in practice. Therapeutic Advances in Gastroenterology 2017; 10(2) doi: 10.1177/1756283X16663396
20
Mihaela Stoyanova, Miglena Milusheva, Milena Georgieva, Penyo Ivanov, George Miloshev, Natalia Krasteva, Kamelia Hristova-Panusheva, Mehran Feizi-Dehnayebi, Ghodsi Mohammadi Ziarani, Kirila Stojnova, Slava Tsoneva, Mina Todorova, Stoyanka Nikolova. Synthesis, Cytotoxic and Genotoxic Evaluation of Drug-Loaded Silver Nanoparticles with Mebeverine and Its Analog. Pharmaceuticals 2025; 18(3) doi: 10.3390/ph18030397
21
Jing Wu, Qinwei Fu, Shasha Yang, Hui Wang, Yaofeng Li, Tarique Hussain. Efficacy and Safety of Acupoint Catgut Embedding for Diarrhea‐Predominant Irritable Bowel Syndrome and Constipation‐Predominant Irritable Bowel Syndrome: A Systematic Review and Meta‐Analysis. Evidence-Based Complementary and Alternative Medicine 2020; 2020(1) doi: 10.1155/2020/5812320
22
Andrea Brusaferro, Edoardo Farinelli, Letizia Zenzeri, Rita Cozzali, Susanna Esposito. The Management of Paediatric Functional Abdominal Pain Disorders: Latest Evidence. Pediatric Drugs 2018; 20(3) doi: 10.1007/s40272-018-0287-z
23
I. G. Pakhomova. Abdominal pain as the main symptom of irritable bowel syndrome: Rationale for the choice of otilonium bromide. Meditsinskiy sovet = Medical Council 2025; (15) doi: 10.21518/ms2025-391
24
Zainab Najim Abdul-Nabi, Ausama Ayob Jaccob, Ali Ghalib M. Redha. Current Cause and Management of Irritable Bowel Syndrome in Basrah, Iraq. Medical Journal of Babylon 2026; 23(1) doi: 10.4103/MJBL.MJBL_854_23
25
Dhiraj M. Rathod, Keyur R. Patel, Hiren N. Mistri, Arvind G. Jangid, Pranav S. Shrivastav, Mallika Sanyal. An improved LC-MS/MS method for the quantification of alverine and para hydroxy alverine in human plasma for a bioequivalence study☆. Journal of Pharmaceutical Analysis 2017; 7(2) doi: 10.1016/j.jpha.2016.11.003
26
Khushi Anand, Mahalaqua Nazli Khatib. Causative Factors, Clinical Manifestations, and Therapeutic Strategies for Irritable Bowel Syndrome. Cureus 2024;  doi: 10.7759/cureus.58728
27
Saeed Mehrzadi, Mohammad Sheibani, Fereshteh Koosha, Nazila Alinaghian, Mohammad Hossein Pourhanifeh, Seid Amir Pasha Tabaeian, Russel J. Reiter, Azam Hosseinzadeh. Protective and therapeutic potential of melatonin against intestinal diseases: updated review of current data based on molecular mechanisms. Expert Review of Gastroenterology & Hepatology 2023; 17(10) doi: 10.1080/17474124.2023.2267439
28
Serhat Bor, Philippe Lehert, Adriana Chalbaud, Jan Tack. Efficacy of pinaverium bromide in the treatment of irritable bowel syndrome: a systematic review and meta-analysis. Therapeutic Advances in Gastroenterology 2021; 14 doi: 10.1177/17562848211033740
29
Wenhui Yang, Hua Guo, Jinbo Niu, Junya Liu, Ran Su, Yingde Bai, Shuang Zhang, Qian Liu, Nan Sun. Phloroglucinol inhibits oxytocin-induced contraction in rat gastric circular muscle and uterine smooth muscle. Journal of Obstetrics and Gynaecology 2023; 43(1) doi: 10.1080/01443615.2022.2130208
30
Jia-Jie Zhu, Shan Liu, Xiao-Lan Su, Zi-Song Wang, Yu Guo, Yi-Jie Li, Yang Yang, Li-Wei Hou, Qing-Guo Wang, Ru-Han Wei, Jian-Qin Yang, Wei Wei, Jiande D. Z. Chen. Efficacy of Chinese Herbal Medicine for Diarrhea‐Predominant Irritable Bowel Syndrome: A Meta‐Analysis of Randomized, Double‐Blind, Placebo‐Controlled Trials. Evidence-Based Complementary and Alternative Medicine 2016; 2016(1) doi: 10.1155/2016/4071260
31
Niranga Manjuri Devanarayana, Shaman Rajindrajith. Irritable bowel syndrome in children: Current knowledge, challenges and opportunities. World Journal of Gastroenterology 2018; 24(21): 2211-2235 doi: 10.3748/wjg.v24.i21.2211
32
Alshimaa M.M. Farag, Hussam M.M. Ibrahim. Does Intravenous Ondansetron Affect the Intestinal Motility Pattern in Healthy Donkeys (Equus asinus)?. Journal of Equine Veterinary Science 2021; 101 doi: 10.1016/j.jevs.2021.103427
33
Teodora Surdea Blaga, Dan L. Dumitrascu, Andrei V. Pop, Simona Grad. The Complex Interplay Between Gut-Brain, Gut-Liver, and Liver-Brain Axes. 2021;  doi: 10.1016/B978-0-12-821927-0.00008-5
34
Kyung Ho Song, Hye-Kyung Jung, Hyun Jin Kim, Hoon Sup Koo, Yong Hwan Kwon, Hyun Duk Shin, Hyun Chul Lim, Jeong Eun Shin, Sung Eun Kim, Dae Hyeon Cho, Jeong Hwan Kim, Hyun Jung Kim. Clinical Practice Guidelines for Irritable Bowel Syndrome in Korea, 2017 Revised Edition. Journal of Neurogastroenterology and Motility 2018; 24(2) doi: 10.5056/jnm17145
35
Yun-zhou Shi, Qing-feng Tao, Di Qin, Min Chen, Shu-guang Yu, Hui Zheng. Acupuncture vs. antispasmodics in the treatment of irritable bowel syndrome: An adjusted indirect treatment comparison meta-analysis. Frontiers in Physiology 2022; 13 doi: 10.3389/fphys.2022.1001978
36
Liang Zheng, Weimin Lu, Qi Xiao, Yaoliang Lai, Heng Fan, Yuling Sun, Dawei Huang, Yuanyuan Wang, Zhen Li, Zhengyan Jiang, Xingxing Liu, Lijuan Zhang, Dongmei Zuo, Zhexing Shou, Qing Tang, Huisuo Huang, Yongqiang Yang, Zongxiang Tang, Jun Xiao. Assessing the post-treatment therapeutic effect of pinaverium in irritable bowel syndrome: a randomized controlled trial. Scientific Reports 2021; 11(1) doi: 10.1038/s41598-021-92990-7
37
Ming Xia. Visceral Pain. 2024;  doi: 10.1007/978-981-99-9167-9_15
38
Dezhen Chen, Wangting Zhou, Yujing Wei, Chenghan Zhuang, Yazheng He, Xiaoli Li, Kaibo Li, Zhaoxia Zhang, Guoqing Zhang. Crystal structure and Hirshfeld surface analysis of pinaverium bromide dihydrate. Powder Diffraction 2025; 40(1) doi: 10.1017/S0885715624000423
39
Sapna Sharma, Roshan Tumdam. Phytochemicals and Gut Health. 2026;  doi: 10.1016/B978-0-443-36372-6.00001-X
40
William E. Bennett. Quantitative Risk–Benefit Analysis of Probiotic Use for Irritable Bowel Syndrome and Inflammatory Bowel Disease. Drug Safety 2016; 39(4) doi: 10.1007/s40264-015-0349-x
41
V. T. Ivashkin, Y. A. Shelygin, E. K. Baranskaya, S. I. Achkasov, S. S. Belous, E. A. Belousova, A. G. Beniashviili, S. V. Vasiliev, E. G. Grigoriev, N. V. Kostenko, A. I. Moskalev, V. N. Kashnikov, I. D. Loranskaya, O. S. Lyashenko, E. A. Poluektova, V. G. Rumyantsev, V. M. Timerbulatov, E. Y. Chashkova, M. V. Shapina, A. A. Sheptulin, O. S. Shifrin, O. Y. Zolnikova, A. Y. Baranovsky, N. V. Korochanskaya, S. N. Mammaev, O. P. Alekseeva, I. B. Khlynov, V. V. Tsukanov, S. A. Alekseenko. Irritable bowel syndrome. Koloproktologia 2022; 21(1) doi: 10.33878/2073-7556-2022-21-1-10-25
42
Kwang Jae Lee. Pharmacologic Agents for Chronic Diarrhea. Intestinal Research 2015; 13(4) doi: 10.5217/ir.2015.13.4.306
43
R. Carmona-Sánchez, M.E. Icaza-Chávez, M.V. Bielsa-Fernández, O. Gómez-Escudero, F. Bosques-Padilla, E. Coss-Adame, F. Esquivel-Ayanegui, Á.R. Flores-Rendón, M.A. González-Martínez, F. Huerta-Iga, A. López-Colombo, T.H. Méndez-Gutiérrez, A. Noble-Lugo, J.R. Nogueira-de Rojas, R.H. Raña-Garibay, J.M. Remes-Troche, F. Roesch-Dietlen, M.J. Schmulson, J.C. Soto-Pérez, J.L. Tamayo, L.F. Uscanga, M.Á. Valdovinos, J. Valerio-Ureña, M.R. Zavala-Solares. Consenso mexicano sobre el síndrome de intestino irritable. Revista de Gastroenterología de México 2016; 81(3) doi: 10.1016/j.rgmx.2016.01.004
44
Amber Hanif Palla, Gereziher Gebremedhin Sibhat, Aman Karim, Najeeb Ur Rehman, Mebrahtom Gebrelibanos Hiben. <p>Multiple Pathway–Mediated Gut-Modulatory Effects of <em>Maerua subcordata</em> (Gilg) DeWolf</p>. Journal of Experimental Pharmacology 2020;  doi: 10.2147/JEP.S254818
45
Chachrit Khunsriraksakul, Olivia Ziegler, Dajiang Liu, Audrey S. Kulaylat, Matthew D. Coates. The Impact of Antispasmodic Use on Abdominal Pain and Opioid Use in Inflammatory Bowel Disease: A Population‐Based Study. Alimentary Pharmacology & Therapeutics 2025; 61(12) doi: 10.1111/apt.70147
46
Emidio Scarpellini, Lucrezia Laterza, Gianluca Ianiro, Jan Tack, Ludovico Abenavoli, Antonio Gasbarrini. Eluxadoline for the treatment of diarrhoea-predominant irritable bowel syndrome. Expert Opinion on Pharmacotherapy 2016; 17(10) doi: 10.1080/14656566.2016.1182982
47
Sheyda Ranjbar, Seyed Afshin Seyednejad, Shekoufeh Nikfar, Roja Rahimi, Mohammad Abdollahi. How can we develop better antispasmodics for irritable bowel syndrome?. Expert Opinion on Drug Discovery 2019; 14(6) doi: 10.1080/17460441.2019.1593369
48
Kayalvizhi Duraisamy, Visweswaran Shanmugasundaram, Narasimhan Srinivasan, Imad A. Abu-Yousef, Amin F. Majdalawieh. Standardization and Evaluation of Antispasmodic Activity of Gandhaga Dravagam Using a Rat Ileum Model. Biophysica 2026; 6(4) doi: 10.3390/biophysica6040063
49
Robyn Rexwinkel, Arine M. Vlieger, Miguel Saps, Merit M. Tabbers, Marc A. Benninga. A therapeutic guide on pediatric irritable bowel syndrome and functional abdominal pain-not otherwise specified. European Journal of Pediatrics 2022; 181(7) doi: 10.1007/s00431-022-04459-y
50
Qiang-Song Wang, Yi-Lun Wang, Wen-Yan Zhang, Kuang-Dai Li, Xiong-Fei Luo, Yuan-Lu Cui. Puerarin from Pueraria lobata alleviates the symptoms of irritable bowel syndrome-diarrhea. Food & Function 2021; 12(5) doi: 10.1039/D0FO02848G
51
O.Yu. Belousova. Irritable bowel syndrome in childhood: treatment in accordance with international guidelines. CHILD`S HEALTH 2024; 19(2) doi: 10.22141/2224-0551.19.2.2024.1681
52
Sang Heon Lee, Sam Ryong Jee. Effect of antispasmodic agents for the treatment of irritable bowel syndrome. Journal of the Korean Medical Association 2018; 61(7) doi: 10.5124/jkma.2018.61.7.428
53
Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Saeideh Momtaz, Faezeh Niazi Shahraki, Nadia Zandi, Benyamin Pazoki, Mohammad Hosein Farzaei, Mehdi Ghasemi, Mohammad Abdollahi, Amir Hossein Abdolghaffari. Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders. Current Pharmaceutical Biotechnology 2024; 25(13) doi: 10.2174/0113892010261502231102040149
54
Krzysztof Drygalski, Mateusz Maciejczyk, Urszula Miksza, Andrzej Ustymowicz, Joanna Godzień, Angelika Buczyńska, Andrzej Chomentowski, Iga Walczak, Karolina Pietrowska, Julia Siemińska, Cezary Pawlukianiec, Przemysław Czajkowski, Joanna Fiedorczuk, Monika Moroz, Beata Modzelewska, Anna Zalewska, Barbara Kutryb-Zając, Tomasz Kleszczewski, Michał Ciborowski, Hady Razak Hady, Marc Foretz, Edyta Adamska-Patruno. New Application of an Old Drug: Anti-Diabetic Properties of Phloroglucinol. International Journal of Molecular Sciences 2024; 25(19) doi: 10.3390/ijms251910291
55
Maximiliano da Silva Sangoi, Anna Karolina Mouzer da Silva Machado, Lorena Coimbra Florindo, Brenda Rocha Gonçalves, Vítor Todeschini. Determination of Pinaverium Bromide in pharmaceutical dosage forms by a validated Stability-Indicating LC Method. Drug Analytical Research 2026; 1(1) doi: 10.22456/2527-2616.73964
56
Valeria Atenea Costa, Alan Felipe Ovalle Hernández. Rol de los antiespasmódicos en el manejo del síndrome de intestino irritable. Revista Colombiana de Gastroenterología 2019; 34(3) doi: 10.22516/25007440.309
57
Marilisa Straface, Raj Makwana, Alexandra Palmer, Laura Rombolà, Joanne Aleong, Luigi Morrone, Gareth Sanger. Inhibition of Neuromuscular Contractions of Human and Rat Colon by Bergamot Essential Oil and Linalool: Evidence to Support a Therapeutic Action. Nutrients 2020; 12(5) doi: 10.3390/nu12051381
58
Lei Zhang, Ruiyun Wang, Tao Bai, Xuelian Xiang, Wei Qian, Jun Song, Xiaohua Hou. EphrinB2/ephB2‐mediated myenteric synaptic plasticity: mechanisms underlying the persistent muscle hypercontractility and pain in postinfectious IBS. The FASEB Journal 2019; 33(12) doi: 10.1096/fj.201901192R
59
Orhan Atay, Jennie David, Ami Mehta. A Hypothetical Case Example Illustrating the Importance of a Multidisciplinary Approach to Treating Chronic/Functional Abdominal Pain in Pediatric Patients. Pediatric Clinics of North America 2022; 69(5) doi: 10.1016/j.pcl.2022.06.005
60
Daisy S. Precilla, Shreyas S. Kuduvalli, Mugilarasi Purushothaman , Parthiban Marimuthu, Arumugam Ramachandran Muralidharan, Thirugnanasambandham Sivasubramanian Anitha. Wnt/β-catenin Antagonists: Exploring New Avenues to Trigger Old Drugs in Alleviating Glioblastoma Multiforme. Current Molecular Pharmacology 2022; 15(2) doi: 10.2174/1874467214666210420115431
61
Giovanni Di Nardo, Giovanni Barbara, Osvaldo Borrelli, Cesare Cremon, Valentina Giorgio, Luigi Greco, Michele La Pietra, Giovanni Marasco, Licia Pensabene, Marisa Piccirillo, Claudio Romano, Silvia Salvatore, Michele Saviano, Vincenzo Stanghellini, Caterina Strisciuglio, Renato Tambucci, Rossella Turco, Letizia Zenzeri, Annamaria Staiano. Italian guidelines for the management of irritable bowel syndrome in children and adolescents. Italian Journal of Pediatrics 2024; 50(1) doi: 10.1186/s13052-024-01607-y
62
Turki Khalid Alshehri, Mohammed Nasser Saeed Alsharif, Lujain Ahmed Ali Asiri, Mohammed Saeed Mukharrib, Mohammed Attieh Alzahrani. Prevalence and Associated Factors of Irritable Bowel Syndrome among Medical Students at King Khalid University. Annals of African Medicine 2025; 24(1) doi: 10.4103/aam.aam_14_19
63
Magnus Simrén, Hans Törnblom, Olafur S Palsson, William E Whitehead. Management of the multiple symptoms of irritable bowel syndrome. The Lancet Gastroenterology & Hepatology 2017; 2(2) doi: 10.1016/S2468-1253(16)30116-9
64
J.M. Remes-Troche, E. Coss-Adame, M. Schmulson, K.R. García-Zermeño, M. Amieva-Balmori, R. Carmona-Sánchez, O. Gómez-Escudero, P.C. Gómez-Castaños, M.E. Icaza-Chávez, A. López-Colombo, E.C. Morel-Cerda, M.Á. Valdovinos-Díaz, L.R. Valdovinos-García, A.S. Villar-Chávez. Tratamiento farmacológico del síndrome de intestino irritable en México. Posicionamiento de la Asociación Mexicana de Gastroenterología 2024. Revista de Gastroenterología de México 2025; 90(1) doi: 10.1016/j.rgmx.2024.10.003
65
Paul Moayyedi, Fermín Mearin, Fernando Azpiroz, Viola Andresen, Giovanni Barbara, Maura Corsetti, Anton Emmanuel, A Pali S Hungin, Peter Layer, Vincenzo Stanghellini, Peter Whorwell, Frank Zerbib, Jan Tack. Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice. United European Gastroenterology Journal 2017; 5(6) doi: 10.1177/2050640617731968
66
Huaiyu Li, Yun Chen, Ziyi Hu, Ying Yi, Jing Ye, Yuliang Zhou, Zhiying Yu, Haiyi Tang. Comparison of acupuncture and pinaverium bromide in the treatment of irritable bowel syndrome. Medicine 2021; 100(16) doi: 10.1097/MD.0000000000025604
67
V. N. Drozdov, K. I. Arefev, S. Yu. Serebrova, I. A. Komissarenko, E. V. Shikh, A. K. Starodubtsev. Role of antispasmodics in the treatment of irritable bowel syndrome. Meditsinskiy sovet = Medical Council 2021; (5) doi: 10.21518/2079-701X-2021-5-155-164
68
Muqeet Wahid, Fatima Saqib, Muhammad Qamar, Zyta M. Ziora. Antispasmodic activity of the ethanol extract of Citrullus lanatus seeds: Justifying ethnomedicinal use in Pakistan to treat asthma and diarrhea. Journal of Ethnopharmacology 2022; 295 doi: 10.1016/j.jep.2022.115314
69
M. A. Osadchuk, M. M. Osadchuk. Antispasmodics in the treatment of abdominal syndrome in IBS and IBS-like syndrome in modern clinical practice. Medical alphabet 2025; (34) doi: 10.33667/2078-5631-2024-34-7-12
70
Di Qin, Qing-Feng Tao, Shi-Le Huang, Min Chen, Hui Zheng. Eluxadoline Versus Antispasmodics in the Treatment of Irritable Bowel Syndrome: An Adjusted Indirect Treatment Comparison Meta-analysis. Frontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.757969
71
Konstantinos E. Keramaris, Konstantinos Konstantopoulos, Lukas H. Margaritis, Athanassios D. Velentzas, Issidora S. Papassideri, Dimitrios J. Stravopodis. Exploitation of Drosophila Choriogenesis Process as a Model Cellular System for Assessment of Compound Toxicity: the Phloroglucinol Paradigm. Scientific Reports 2020; 10(1) doi: 10.1038/s41598-019-57113-3
72
Mustafa Arısoy, Mehtap Saydam, Yasemin Ekin Dolaksız, Çağrı Talay, Onursal Sağlam, Gökçe Demiray, Emel Doğan Kurtoğlu. A Study to Compare Bioequivalence Approach Between FDA and EMA in a Highly Variable Drug: Pinaverium Bromide Film Tablets. Journal of Pharmaceutical Sciences 2022; 111(11) doi: 10.1016/j.xphs.2022.08.010
73
Caroline Valibouze, Caroline Dubuquoy, Philippe Chavatte, Michaël Genin, Veronique Maquet, Salvatore Modica, Pierre Desreumaux, Christel Rousseaux. Chitin-glucan improves important pathophysiological features of irritable bowel syndrome. World Journal of Gastroenterology 2024; 30(16): 2258-2271 doi: 10.3748/wjg.v30.i16.2258
74
Edward Thomas Andrews, R Mark Beattie, Mark P Tighe. Functional abdominal pain: what clinicians need to know. Archives of Disease in Childhood 2020; 105(10) doi: 10.1136/archdischild-2020-318825
75
O. V. Krapivnaya, S. A. Alekseenko. Comparative evaluation of efficacy of Pinaverium monotherapy and combination therapy of Pinaverium with itopride hydrochloride in patients with cross irritable bowel syndrome with constipation and postpradial distress syndrome. Medical alphabet 2019; 3(20) doi: 10.33667/2078-5631-2019-2-20(395)-54-57
76
Mihaela Stoyanova, Miglena Milusheva, Vera Gledacheva, Iliyana Stefanova, Mina Todorova, Nikoleta Kircheva, Silvia Angelova, Mina Pencheva, Kirila Stojnova, Slava Tsoneva, Stoyanka Nikolova. Spasmolytic Activity and Anti-Inflammatory Effect of Novel Mebeverine Derivatives. Biomedicines 2024; 12(10) doi: 10.3390/biomedicines12102321
77
Gina Wodarczyk, Maria Winte, Diana Mastellone, Termen Singh, Joshua DeSipio, Sangita Phadtare. Biotic therapies for irritable bowel syndrome: current interventions. Gastroenterology Report 2026; 14 doi: 10.1093/gastro/goag062
78
Clara Blanchard, Denis Pouchain, Paul Vanderkam, Marie-Christine Perault-Pochat, Rémy Boussageon, Hélène Vaillant-Roussel. Efficacy of phloroglucinol for treatment of abdominal pain: a systematic review of literature and meta-analysis of randomised controlled trials versus placebo. European Journal of Clinical Pharmacology 2018; 74(5) doi: 10.1007/s00228-018-2416-6
79
Di Qin, Ling Yue, Bin Xue, Min Chen, Tai-Chun Tang, Hui Zheng. Pharmacological treatments for patients with irritable bowel syndrome. Medicine 2019; 98(32) doi: 10.1097/MD.0000000000015920
80
Giovanni Barbara, Cesare Cremon, Massimo Bellini, Maura Corsetti, Giovanni Di Nardo, Francesca Falangone, Lorenzo Fuccio, Francesca Galeazzi, Paola Iovino, Giovanni Sarnelli, Edoardo Vincenzo Savarino, Vincenzo Stanghellini, Annamaria Staiano, Cristina Stasi, Cesare Tosetti, Rossella Turco, Enzo Ubaldi, Rocco Maurizio Zagari, Letizia Zenzeri, Giovanni Marasco. Italian guidelines for the management of irritable bowel syndrome. Digestive and Liver Disease 2023; 55(2) doi: 10.1016/j.dld.2022.11.015
81
Orla Craig. New therapies in Irritable Bowel Syndrome. Current Opinion in Gastroenterology 2018; 34(1) doi: 10.1097/MOG.0000000000000411
82
Shuai Gao, Xia Yao, Jiaofeng Chen, Gaoxingyu Huang, Xiao Fan, Lingfeng Xue, Zhangqiang Li, Tong Wu, Yupeng Zheng, Jian Huang, Xueqin Jin, Yan Wang, Zhifei Wang, Yong Yu, Lei Liu, Xiaojing Pan, Chen Song, Nieng Yan. Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell 2023; 186(24) doi: 10.1016/j.cell.2023.10.007
83
Irritable Bowel Syndrome. Physician Assistant Clinics 2026; 11(4) doi: 10.1016/j.cpha.2026.04.004
84
An Open-label Prospective Study to Assess the Effectiveness, Tolerability, and Safety of <i>Ayurvedic</i> Intervention (<i>Kutajarishta</i>) in the Treatment of Irritable Bowel Syndrome. Journal of Natural Remedies 2025;  doi: 10.18311/jnr/2025/36414
85
Oleg N. Minushkin, Olga V. Khlynova, Stanislav I. Sitkin, Emilia P. Yakovenko, Yuri A. Kravchuk, Pavel V. Seliverstov, Elena A. Belousova. The potential for improving the efficacy of treatment for irritable bowel syndrome with a multi-target drug alverine citrate plus simethicone: The Expert Panel Statement. Almanac of Clinical Medicine 2024; 52(4) doi: 10.18786/2072-0505-2024-52-023
86
Sundeep Lakhtakia, Anudeep V. Katrevula, Goutham R. Katukuri. Managing irritable bowel syndrome via gut-brain axis modulation and antispasmodic - anxiolytic dual action: an Indian expert panel review. International Journal of Research in Medical Sciences 2025;  doi: 10.18203/2320-6012.ijrms20254245
87
Jaroslaw Daniluk, Ewa Malecka-Wojciesko, Barbara Skrzydlo-Radomanska, Grazyna Rydzewska. The Efficacy of Mebeverine in the Treatment of Irritable Bowel Syndrome—A Systematic Review. Journal of Clinical Medicine 2022; 11(4) doi: 10.3390/jcm11041044
88
Shaman Rajindrajith, Judith Zeevenhooven, Niranga Manjuri Devanarayana, Bonaventure Jayasiri Crispus Perera, Marc A. Benninga. Functional abdominal pain disorders in children. Expert Review of Gastroenterology & Hepatology 2018; 12(4) doi: 10.1080/17474124.2018.1438188
89
J.M. Remes-Troche, E. Coss-Adame, M. Schmulson, K.R. García-Zermeño, M. Amieva-Balmori, R. Carmona-Sánchez, O. Gómez-Escudero, P.C. Gómez-Castaños, M.E. Icaza-Chávez, A. López-Colombo, E.C. Morel-Cerda, M.Á. Valdovinos-Díaz, L.R. Valdovinos-García, A.S. Villar-Chávez. Pharmacologic treatment of irritable bowel syndrome. Position statement of the Asociación Mexicana de Gastroenterología, 2024. Revista de Gastroenterología de México (English Edition) 2025; 90(1) doi: 10.1016/j.rgmxen.2024.10.009
90
K. N. Khalaidzheva, V. N. Drozdov, E. V. Shikh, S. Yu. Serebrova. The place of antispasmodic drugs in modern therapy of irritable bowel syndrome. Meditsinskiy sovet = Medical Council 2023; (8) doi: 10.21518/ms2023-127
91
Ramesh R. Rai, Sandeep Nijhawan. Comparative evaluation of efficacy and safety of drotaverine versus mebeverine in irritable bowel syndrome. Saudi Journal of Gastroenterology 2021; 27(3) doi: 10.4103/sjg.SJG_266_20
92
J. Scanzi, A. Accarie, E. Muller, B. Pereira, Y. Aissouni, M. Goutte, J. Joubert‐Zakeyh, E. Picard, L. Boudieu, C. Mallet, A. Gelot, D. Ardid, F. A. Carvalho, M. Dapoigny. Colonic overexpression of the T‐type calcium channel Cav3.2 in a mouse model of visceral hypersensitivity and in irritable bowel syndrome patients. Neurogastroenterology & Motility 2016; 28(11) doi: 10.1111/nmo.12860
93
Gamal A. E. Mostafa, Maha F. El-Tohamy, Haitham Alrabiah. Prospective of Agro-Waste Husks for Biogenic Synthesis of Polymeric-Based CeO2/NiO Nanocomposite Sensor for Determination of Mebeverine Hydrochloride. Molecules 2023; 28(5) doi: 10.3390/molecules28052095
94
Simona Rizea-Savu, Simona Nicoleta Duna, Roxana Colette Sandulovici. Single Dose Study Assessing the Pharmacokinetic and Metabolic Profile of Alverine Citrate in Healthy Volunteers. Frontiers in Pharmacology 2021; 11 doi: 10.3389/fphar.2020.620451
95
Dmitry I. Trukhan, Viktoriia V. Goloshubina. Irritable bowel syndrome: current aspects of etiology, pathogenesis, clinic and treatment: A review. Consilium Medicum 2022; 24(5) doi: 10.26442/20751753.2022.5.201861
96
Shengyi Liu, Yinghong Li, Zihua He, Xiutian Sima, Jinmei Li. Efficacy of internet-based cognitive behavioral therapy on somatic symptom disorder and common related functional disorders: A meta-analysis of randomized controlled trials. General Hospital Psychiatry 2026; 99 doi: 10.1016/j.genhosppsych.2026.01.017
97
. 2018;  doi: 10.70675/42c7a86czd734z4a38zba45z18b45741ec10
98
Deepak Chandra Joshi, Neha Raina, Nirmal Joshi, Kajal Gurow, Jyoti Gwasakoti, Abhilasha Sood, Arpit Mehrotra, Hardeep Singh Tuli, Keshav Raj Paudel, Madhu Gupta. Current Landscape of Novel Therapeutic Agents and Drug Targets in Irritable Bowel Syndrome. Archiv der Pharmazie 2025; 358(11) doi: 10.1002/ardp.70133
99
Rodolfo Sacco, Antonio Facciorusso, Edoardo Giannini, Massimo Bellini. Revisiting Abdominal Pain in IBS: From Pathophysiology to Targeted Management with Alverine Citrate/Simeticone. Journal of Clinical Medicine 2026; 15(2) doi: 10.3390/jcm15020722
100
Krzysztof Drygalski, Katarzyna Siewko, Andrzej Chomentowski, Cezary Odrzygóźdź, Anna Zalewska, Adam Krętowski, Mateusz Maciejczyk, Ayman Mahmoud. Phloroglucinol Strengthens the Antioxidant Barrier and Reduces Oxidative/Nitrosative Stress in Nonalcoholic Fatty Liver Disease (NAFLD). Oxidative Medicine and Cellular Longevity 2021; 2021(1) doi: 10.1155/2021/8872702
101
Aiya Aboubakr, Michelle S. Cohen. Functional Bowel Disease. Clinics in Geriatric Medicine 2021; 37(1) doi: 10.1016/j.cger.2020.08.009
102
Yucui Zhao, Jiaguo Zhan, Congying Sun, Shixiao Zhu, Yue Zhai, Yongna Dai, Xiaoying Wang, Xiumei Gao. Sishen Wan enhances intestinal barrier function via regulating endoplasmic reticulum stress to improve mice with diarrheal irritable bowel syndrome. Phytomedicine 2024; 129 doi: 10.1016/j.phymed.2024.155541
103
Arta Aliu, Daan H. C. A. Bosch, Daniel Keszthelyi, Ashkan Rezazadeh Ardabili, Jean‐Frederic Colombel, Rachel Sawyer, Hans Törnblom, Ailsa Hart, Daisy M. A. E. Jonkers, Marieke J. Pierik, Zlatan Mujagic. Review article: A practical approach to persistent gastrointestinal symptoms in inflammatory bowel disease in remission. Alimentary Pharmacology & Therapeutics 2024; 59(12) doi: 10.1111/apt.17988
104
V. T. Ivashkin, I. V. Maev, Yu. A. Shelygin, E. K. Baranskaya, S. S. Belous, E. A. Belousova, A. G. Beniashvili, S. V. Vasilyev, A. V. Veselov, E. G. Grigoryev, N. V. Kostenko, V. N. Kashnikov, V. F. Kulikovskiy, I. D. Loranskaya, O. S. Lyashenko, E. A. Poluektova, V. G. Rumyantsev, V. M. Timerbulatov, O. Yu. Fomenko, D. A. Khubezov, E. Yu. Chashkova, G. I. Chibisov, M. V. Shapina, A. A. Sheptulin, O. S. Shifrin, A. S. Trukhmanov, O. P. Alekseeva, S. A. Alekseenko, A. Yu. Baranovsky, O. Yu. Zolnikova, N. V. Korochanskaya, S. N. Mammayev, I. B. Khlynov, V. V. Tsukanov. Diagnosis and Treatment of Irritable Bowel Syndrome: Clinical Recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia. Russian Journal of Gastroenterology, Hepatology, Coloproctology 2022; 31(5) doi: 10.22416/1382-4376-2021-31-5-74-95
105
Conor O’Croinin, Andres Garcia Guerra, Michael R. Doschak, Raimar Löbenberg, Neal M. Davies. Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa. Pharmaceutics 2023; 15(7) doi: 10.3390/pharmaceutics15071941
106
R. Carmona-Sánchez, M.E. Icaza-Chávez, M.V. Bielsa-Fernández, O. Gómez-Escudero, F. Bosques-Padilla, E. Coss-Adame, F. Esquivel-Ayanegui, Á.R. Flores-Rendón, M.A. González-Martínez, F. Huerta-Iga, A. López-Colombo, T.H. Méndez-Gutiérrez, A. Noble-Lugo, J.R. Nogueira-de Rojas, R.H. Raña-Garibay, J.M. Remes-Troche, F. Roesch-Dietlen, M.J. Schmulson, J.C. Soto-Pérez, J.L. Tamayo, L.F. Uscanga, M.Á. Valdovinos, J. Valerio-Ureña, M.R. Zavala-Solares. The Mexican consensus on irritable bowel syndrome. Revista de Gastroenterología de México (English Edition) 2016; 81(3) doi: 10.1016/j.rgmxen.2016.01.004
107
L.B. Bondarenko, N.O. Gorchakova, O.K. Biloshitska, O.Ya. Bespalova. Pharmacotherapeutic characteristics of the combination of phloroglucinol and simethicone in the context of the treatment of spastic conditions of the gastrointestinal tract (literature review). The Journal of V. N. Karazin Kharkiv National University, Series "Medicine" 2025; (54) doi: 10.26565/2313-6693-2025-54-12
108
Hossein Taghadosi, Farhad Tabatabai Ghomsheh, Aydin Farajidavar, Faezeh Khazaee, Fatemeh Hoseinpour. The effect of calcium channels blockade on slow-wave distribution in the electrophysiological model of human gastric wall smooth muscle cells. Physiology and Pharmacology 2023; 27(3) doi: 10.61186/phypha.27.3.319
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