Published online Jun 8, 2025. doi: 10.37126/aige.v6.i2.106600
Revised: April 2, 2025
Accepted: April 21, 2025
Published online: June 8, 2025
Processing time: 96 Days and 13.7 Hours
Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has emerged as an effective and minimally invasive alternative for treating gastric outlet obstruction. Compared to traditional options, including duodenal stenting and surgical gastrojejunostomy, EUS-GE offers comparable technical and clinical success while providing longer-lasting patency, fewer adverse events, and lower reintervention rates. The technique has expanded beyond malignant obstruction to include benign etiologies and complex conditions such as afferent loop syndrome. EUS-GE enables rapid recovery and early resumption of oral intake, which is crucial for oncologic patients. However, the procedure remains technically demanding, and optimal techniques, device selection, and management of complications are still under investigation. This mini-review summarizes current evidence, com
Core Tip: Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) has emerged as a promising minimally invasive treatment for gastric outlet obstruction, challenging traditional surgical gastrojejunostomy and duodenal stenting. It offers rapid recovery, improved symptom relief, and reduced reintervention rates, particularly benefiting oncologic patients. Despite its advantages, EUS-GE remains technically complex, requiring refinement in technique, standardization, and training programs. Issues such as stent misdeployment, long-term outcomes, and best technical approaches remain unresolved. Further studies, including randomized trials, are needed to establish EUS-GE as the standard of care, optimize safety, and expand indications, including potential applications in bariatric endoscopy and gastroparesis management.