Is there a role for liver transplantation in the treatment of hepatocellular carcinoma in non-cirrhotic liver?

Table 1 Selected series that addressed the long-term survival of patients with non-cirrhotic liver - hepatocellular carcinoma treated with primary or rescue liver transplantation

Ref.	HCC variant	n	Recurrence rate (%)	5-year OS (%)
Pichlmayr et al[22], 1995	FL	36	38.0	49.0
Pinna et al[23], 1997	FL	13	69.2	36.3
Schlitt et al[25], 1999	FL	25	NR	27.0
El-Gazzaz et al[26], 2000	FL	9	44.0	50.0
Mergental et al[27], 2012	NS	105	48.5	53.5

HCC: Hepatocellular carcinoma; OS: Overall survival; FL: Fibrolamellar; NR: Not reported; NS: Not specified.

Table 2 Series of patients with hepatocellular carcinoma in non-cirrhotic liver treated with liver transplantation with reported risk factors for poor prognosis

Ref.	Risk factors
Pichlmayr et al[22], 1995	> 1 tumor; lymph node invasion
Pinna et al[23], 1997	Tumor stage; macrovascular invasion; lymph node invasion
El-Gazzaz et al[26], 2000	Tumor stage
Mergental et al[27], 2012	Macrovascular invasion; lymph node involvement; time interval between resection and LT < 1 yr

LT: Liver transplantation.