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World J Meta-Anal. Apr 28, 2021; 9(2): 176-192
Published online Apr 28, 2021. doi: 10.13105/wjma.v9.i2.176
Therapeutic applications of dental pulp stem cells in regenerating dental, periodontal and oral-related structures
Mohammed E Grawish, Mahmoud A Saeed, Nessma Sultan, Ben A Scheven
Mohammed E Grawish, Nessma Sultan, Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura 35516, Egypt
Mohammed E Grawish, Mahmoud A Saeed, Department of Oral Biology, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Mansoura 11152, Egypt
Ben A Scheven, School of Dentistry, Oral Biology, College of Medical and Dental Sciences, University of Birmingham, Birmingham B5 7EG, United Kingdom
Author contributions: Grawish ME conceptualized the idea, wrote and reviewed the manuscript; Saeed MA, Sultan N and Scheven BA contributed to writing of the manuscript and provided intellectual contribution to the content; All authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammed E Grawish, MSc, PhD, Professor, Department of Oral Biology, Faculty of Dentistry, Mansoura University, Dakahlia Governorate, Mansoura 35516, Egypt. grawish2005@yahoo.com
Received: February 2, 2021
Peer-review started: February 2, 2021
First decision: March 8, 2021
Revised: March 13, 2021
Accepted: April 23, 2021
Article in press: April 23, 2021
Published online: April 28, 2021
Processing time: 85 Days and 2.9 Hours
Core Tip

Core Tip: Dental pulp stem cells (DPSCs) can be isolated from the pulps of impacted teeth requiring surgical extraction or from teeth extracted for orthodontic reasons. In addition, there is growing evidence that DPSCs can be isolated from inflamed pulps derived from carious teeth with symptomatic irreversible pulpitis. DPSCs are neural crest in origin, and thus they differentiate into an astonishing array of cell types and tissues and regenerate structures that have the same developmental origin, like dentin-pulp complex, periodontal tissues, stromal tissues of salivary glands and craniomaxillofacial bone defects.