Meta-Analysis
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Aug 26, 2016; 4(4): 95-104
Published online Aug 26, 2016. doi: 10.13105/wjma.v4.i4.95
Gadoxetic acid-enhanced magnetic resonance imaging for the detection of small hepatocellular carcinoma (≤ 2.0 cm) in patients with chronic liver disease: A meta-analysis
Yan Shan, Jian Gao, Meng-Su Zeng, Jiang Lin, Peng-Ju Xu
Yan Shan, Meng-Su Zeng, Jiang Lin, Peng-Ju Xu, Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Shanghai 200032, China
Jian Gao, Center of Clinical Epidemiology and Evidence-based Medicine, Fudan University, Shanghai 200032, China
Author contributions: Shan Y, Gao J and Xu PJ concepted/designed this study; all authors contributed to data acquisition or data analysis/interpretation; Shan Y, Gao J and Xu PJ drafting or revision this manuscript for important intellectual content; Gao J contributed to statistical analysis; Shan Y and Gao J contributed equally to this work.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: Supplementary files provide detailed description of 10 studies included in the meta-analysis.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Peng-Ju Xu, MD, Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, 180 Fenglin Road, Shanghai 200032, China. xpjbfc@163.com
Telephone: +86-21-64041990 Fax: +86-21-64038472
Received: March 11, 2016
Peer-review started: March 14, 2016
First decision: April 14, 2016
Revised: April 28, 2016
Accepted: June 14, 2016
Article in press: June 16, 2016
Published online: August 26, 2016
Processing time: 167 Days and 22.1 Hours
Core Tip

Core tip: Although studies have shown that gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) had good diagnostic performance in detecting hepatocellular carcinoma (HCC), the results about small HCC have been limited thus far by a small number of included patients, especially for subcentimeter lesion (≤ 1.0 cm). Therefore, we performed a systematic review and meta-analysis to obtain updated diagnostic performance values of Gd-EOB-MRI for the detection of small HCC in terms of different size (≤ 2.0 cm vs≤ 1.0 cm), different technique (Gd-EOB-MRI alone vs combined diffusion weighted imaging).