Meta-Analysis
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Feb 26, 2016; 4(1): 1-9
Published online Feb 26, 2016. doi: 10.13105/wjma.v4.i1.1
Expression of epithelial cellular adhesion molecule in gastric cancer: A meta-analysis
Yi-Bin Xiao, Hong-Qing Xi, Ji-Yang Li, Lin Chen
Yi-Bin Xiao, Hong-Qing Xi, Ji-Yang Li, Lin Chen, Department of General Surgery, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Author contributions: Xiao YB and Xi HQ contributed equally to this work; Xiao YB and Chen L designed the research; Xiao YB and Xi HQ collected and analyzed the data; Xiao YB wrote and revised the manuscript; Li JY provided analytic tools and checked the accuracy of the data.
Supported by The National High Technology Research and Development Program of China, No. 2012AA02A504.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lin Chen, MD, Professor, Department of General Surgery, Chinese People’s Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China. chenlinbj@sina.com
Telephone: +86-10-66938128 Fax: +86-10-68181689
Received: August 23, 2015
Peer-review started: September 3, 2015
First decision: November 13, 2015
Revised: December 1, 2015
Accepted: January 29, 2016
Article in press: January 31, 2016
Published online: February 26, 2016
Processing time: 168 Days and 3.8 Hours
Core Tip

Core tip: This meta-analysis aimed to obtain an accurate evaluation of the association between high expression of epithelial cellular adhesion molecule (EpCAM) and gastric cancer (GC) risk. EpCAM-positive cases were significantly associated with tumor size, depth of invasion, TNM stage, tumor location, histologic differentiation and lymph node metastasis. EpCAM contributed to GC risk, and acted as a prognostic factor and a marker of poor outcome.