Palalay H, Vyas R, Tafuto B. Real-world effectiveness of mRNA COVID-19 vaccines in the elderly during the Delta and Omicron variants: Systematic review. World J Meta-Anal 2023; 11(5): 167-180 [PMID: 37575964 DOI: 10.13105/wjma.v11.i5.167]
Corresponding Author of This Article
Harvey Palalay, MS, RN, Master's Student, Department of Health Informatics, Rutgers University, 675 Hoes Lane West, Piscataway, NJ 08854, United States. hkp48@shp.rutgers.edu
Research Domain of This Article
Public, Environmental & Occupational Health
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Meta-Anal. Jun 18, 2023; 11(5): 167-180 Published online Jun 18, 2023. doi: 10.13105/wjma.v11.i5.167
Real-world effectiveness of mRNA COVID-19 vaccines in the elderly during the Delta and Omicron variants: Systematic review
Harvey Palalay, Riddhi Vyas, Barbara Tafuto
Harvey Palalay, Riddhi Vyas, Barbara Tafuto, Department of Health Informatics, Rutgers University, Piscataway, NJ 08854, United States
Author contributions: Palalay H conceived the manuscript from study design, literature search, study selection process, data extraction, analysis, and synthesis; Tafuto B reviewed the draft, added critical comment and intellectual content, and participated in most of the study steps; Vyas R provided additional input and guidance; All authors read and approved the final manuscript for submission and take full responsibility for the content.
Conflict-of-interest statement: No conflict of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Harvey Palalay, MS, RN, Master's Student, Department of Health Informatics, Rutgers University, 675 Hoes Lane West, Piscataway, NJ 08854, United States. hkp48@shp.rutgers.edu
Received: January 28, 2023 Peer-review started: January 28, 2023 First decision: March 28, 2023 Revised: April 9, 2023 Accepted: April 18, 2023 Article in press: April 18, 2023 Published online: June 18, 2023 Processing time: 138 Days and 21.5 Hours
Core Tip
Core Tip: This systematic review investigates the real-world effectiveness of mRNA coronavirus disease 2019 (COVID-19) vaccines in reducing morbidity and mortality in the elderly during the predominance of Delta and Omicron variants. This study found that the effectiveness of mRNA COVID-19 vaccines in the elderly against the Delta and Omicron variants is marginally lower than what was suggested in clinical trial data. Vaccine efficacy also diminishes over time, indicating the need for a booster dose to restore its effectiveness. Furthermore, to better understand and respond to an epidemic, studies should utilize common outcome measurements or minimize heterogeneity in outcome measures to facilitate data comparison and integration of results.
