Dehydroepiandrosterone sulfate supplementation in health and diseases

Core Tip

Core Tip: In this review we discuss the current evidence for the nutraceutical utility of dehydroepiandrosterone sulfate (DHEAS). Initially regarded as a panacea for a multitude of human diseases, studies conducted with DHEA supplementation have yielded largely inconclusive results, with the possible exception as an alternative agent in adrenal insufficiency patients with low energy and low libido (in affected females), and genitourinary syndrome of menopause (vaginal preparation). However, with its easy availability as a relatively inexpensive over-the-counter supplement in many countries, DHEA, like vitamin D, has continued to evoke curiosity in the scientific community. Hence, the subject of DHEA supplementation requires a pragmatic approach, backed by robust evidence, with careful weighing of potential benefits (or lack thereof) and possible adverse effects.