Meta-Analysis
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World J Meta-Anal. Nov 26, 2013; 1(3): 130-137
Published online Nov 26, 2013. doi: 10.13105/wjma.v1.i3.130
Statin use and risk of liver cancer: A meta-analysis of 7 studies involving more than 4.7 million patients
Hui Zhang, Chun Gao, Long Fang, Shu-Kun Yao
Hui Zhang, Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
Chun Gao, Long Fang, Shu-Kun Yao, Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China
Author contributions: Zhang H participated in the acquisition of data, statistical analysis and manuscript writing; Gao C and Fang L conceived the study and participated in the study design, acquisition of data, statistical analysis and manuscript writing; Yao SK participated in the critical revision of the manuscript for important intellectual content; and all authors have read and approved the final manuscript.
Supported by Beijing NOVA Programme, No. Z131107000413067; and the Research Fund of the China-Japan Friendship Hospital, Nos. 2013-QN-07 and 2013-QN-06
Correspondence to: Chun Gao, MD, Department of Gastroenterology, China-Japan Friendship Hospital, Ministry of Health, No. 2 Yinghua East Road, Beijing 100029, China. gaochun@bjmu.edu.cn
Telephone: +86-10-84205313 Fax: +86-10-84205313
Received: June 21, 2013
Revised: September 12, 2013
Accepted: November 20, 2013
Published online: November 26, 2013
Processing time: 181 Days and 3.4 Hours
Core Tip

Core tip: Statin use has been suggested to be associated with the risk of liver cancer by some studies, but no consensus was reached among them. This meta-analysis involved 4725593 people, 9785 liver cancer cases, and found that statin use was associated with the reduced risk of liver cancer (RR = 0.67, 95%CI: 0.55-0.82, P < 0.001).