Yang YL, Hu BJ, Yi J, Pan MZ, Xie PC, Duan HW. Effects of dexmedetomidine on cardioprotection and other postoperative complications in elderly patients after cardiac and non-cardiac surgerie. World J Meta-Anal 2022; 10(1): 25-36 [DOI: 10.13105/wjma.v10.i1.25]
Corresponding Author of This Article
Hong-Wei Duan, Doctor, MHSc, Chief Physician, Professor, Department of Anesthesia, Pudong Hospital, No. 2800 Gongwei Road, Pudong New Area, Shanghai 201399, China. duanhongwei120@163.com
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yang-Liang Yang, Hong-Wei Duan, Department of Anesthesia, Pudong Hospital, Shanghai 201399, China
Bao-Ji Hu, Jing Yi, Meng-Zhi Pan, Peng-Cheng Xie, Department of Anesthesiology, Fudan University Pudong Medical Center, Fudan University, Shanghai 201399, China
Author contributions: Yang YL conceived and designed the study; Yi J, Hu BJ and Duan HW collected the data and performed the literature search; Yang YL was involved in the writing of the manuscript; Pan MZ and Xie PC contributed equally to this work; all authors have read and approved the final manuscript.
Supported byNational Health and Family Planning Commission of the People's Republic of China, National Clinical Key Specialty Project Foundation, No. PWZzk2017-06.
Conflict-of-interest statement: The authors declare no competing interests.
PRISMA 2009 Checklist statement: We have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Wei Duan, Doctor, MHSc, Chief Physician, Professor, Department of Anesthesia, Pudong Hospital, No. 2800 Gongwei Road, Pudong New Area, Shanghai 201399, China. duanhongwei120@163.com
Received: October 11, 2021 Peer-review started: October 11, 2021 First decision: December 10, 2021 Revised: December 24, 2021 Accepted: February 12, 2022 Article in press: February 12, 2022 Published online: February 28, 2022 Processing time: 139 Days and 21.6 Hours
ARTICLE HIGHLIGHTS
Research background
There was also a consistent conclusion on whether dexmedetomidine had a protective effect on the heart and improved postoperative complications, for which we conducted a meta-analysis.
Research motivation
It has guiding significance for clinical application of dexmedetomidine on the heart and postoperative complications in elderly patients undergoing cardiac or non-cardiac surgery.
Research objectives
Our main goal is to investigate the effects of dexmedetomidine on cardiac complications and delirium in elderly patients undergoing cardiac or non-cardiac surgery.
Research methods
We collected references to randomized controlled trials examining the efficacy of dexmedetomidine in the treatment of cardiac and postoperative complications.
Research results
Dexmedetomidine significantly reduced the cardiac troponin I and he inflammatory factor tumor necrosis factor-α, and reduced the extubation time, postoperative delirium and mortality. It really brings benefits to patients.
Research conclusions
Dexmedetomidine has cardioprotective effects and improves patient postoperative complications.
Research perspectives
In clinical practice, we will study the effect of dexmedetomidine at an appropriate dose on the heart and postoperative complications which will have certain guiding significance.
