Single-balloon and spiral enteroscopy may have similar diagnostic and therapeutic yields to double-balloon enteroscopy: Results from a meta-analysis of randomized controlled trials and prospective studies

doi:10.13105/wjma.v8.i2.153

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 8, Issue 2

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (8734)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-2) series.

Item

Count

PDF

422

WORD

191

HTML

3867

Figures (1-3)

604

Tables (1-2)

612

Sum=5696

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1008

Download

2044

Sum=3052

Apr 28, 2020 (publication date) through Feb 27, 2026

Times Cited of This Article

Times Cited (2)

Journal Information of This Article

Publication Name

World Journal of Meta-Analysis

ISSN

2308-3840

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Meta-Analysis

World J Meta-Anal. Apr 28, 2020; 8(2): 153-162
Published online Apr 28, 2020. doi: 10.13105/wjma.v8.i2.153

Single-balloon and spiral enteroscopy may have similar diagnostic and therapeutic yields to double-balloon enteroscopy: Results from a meta-analysis of randomized controlled trials and prospective studies

Yong Gu, Xin Shi, Yan Yang, Xiao-Fei Ye, Qiong Wu, Zhi-Ping Yang, Shui-Xiang He

Yong Gu, Shui-Xiang He, Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China

Yong Gu, Department of Digestive System Diseases, Shaanxi Provincial Crops Hospital of Chinese People's Armed Police Force, Xi'an 710054, Shaanxi Province, China

Xin Shi, Yan Yang, Qiong Wu, Zhi-Ping Yang, State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China

Xiao-Fei Ye, Department of Health Statistics, Second Military Medical University, Shanghai 200433, China

Author contributions: Gu Y, Shi X, and Yang Y contributed equally to this work; He SX and Yang ZP were the co-corresponding authors, and contributed to study conception and design; Shi X and Wu Q performed the analysis and interpretation of the data; Gu Y and Yang Y drafted the manuscript; Yang ZP critically revised the article for important intellectual content; and He SX approved the final manuscript.

Conflict-of-interest statement: All authors declare no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.

Corresponding author: Shui-Xiang He, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, Shaanxi Province, China. hesx123@126.com

Received: December 12, 2019
Peer-review started: December 12, 2019
First decision: January 7, 2020
Revised: January 7, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 28, 2020
Processing time: 138 Days and 1.8 Hours

Abstract

BACKGROUND

Double-balloon, single-balloon, and spiral enteroscopy (DBE, SBE, and SE) have revolutionized the management of intestinal diseases. However, evidence about efficacies of these methods is lacking. We aimed to conduct a meta-analysis comparing the clinical outcomes among DBE, SBE, and SE.

METHODS

We searched randomized controlled trials and prospective studies in MEDLINE, PubMed, EMBASE, Cochrane Library, and Chinese CQVIP database. Studies referencing the comparison of at least two of these three methods were included. Primary outcome was diagnostic yield. Other outcomes were therapeutic yield, total enteroscopy, examination time, time to maximum insertion, and depth of maximal insertion (DMI).

RESULTS

Eleven studies including 727 patients were identified: DBE vs SE (n = 6), DBE vs SBE (n = 4), and SBE vs SE (n = 1). The diagnostic and therapeutic yields did not differ significantly when comparing DBE with SE [odds ratio (OR) = 1.19, 95% confidence interval (CI): 0.68-2.08; OR = 1.17, 95%CI: 0.61-2.23] and DBE with SBE (OR = 0.85, 95%CI: 0.55-1.33; OR = 1.71, 95%CI: 0.64 - 4.60). Total enteroscopy, examination time, time to maximum insertion, and DMI were similar between SBE and DBE. DBE was superior to SE with regard to DMI [mean difference (MD) = 36.76, 95%CI: 5.09-68.43], with longer time to maximum insertion (MD = 15.14, 95%CI: 12-18.27) and examination time (MD = 12.98, 95%CI: 9.57-16.38).

CONCLUSION

DBE and SBE have similar clinical outcomes. Compared with DBE, SE seems to have similar diagnostic and therapeutic yields, but shorter procedural time in cost of less depth of insertion. SE needs further evaluation vs SBE. DBE is recommended for complete enteroscopy.

Keywords: Double-balloon enteroscopy; Single-balloon enteroscopy; Spiral enteroscopy; Meta-analysis; Randomized controlled trials

Core tip: We conducted a meta-analysis to compare the effectiveness of double-balloon, single-balloon, and spiral enteroscopy. We found that double-balloon enteroscopy may have similar clinical outcomes to single-balloon enteroscopy, and spiral enteroscopy seems to have similar diagnostic and therapeutic yields, but shorter procedural time in cost of less depth of insertion when compared with double-balloon enteroscopy.