Published online Jul 31, 2019. doi: 10.13105/wjma.v7.i7.358
Peer-review started: May 14, 2019
First decision: July 26, 2019
Revised: July 27, 2019
Accepted: July 29, 2019
Article in press: July 29, 2019
Published online: July 31, 2019
Processing time: 82 Days and 2.7 Hours
Ischemic stroke is a frequently-occurring disease in the elderly and characterized by high morbidity and mortality. Dl-3-n-butylphthalide (NBP), a synthetic compound based on natural celery seeds, has potential therapeutic effects on cerebral ischemia, brain trauma, memory impairment, and epilepsy.
To evaluated the effect of NBP on infarct volume in experimental ischemic stroke.
Twenty one relevant literatures were included from the PubMed, EMBASE, Web of Science, Chinese National Knowledge Infrastructure, VIP information database, and Wanfang database, and data on the effect of dl-3-n-butylphthalide on infarction volume in the middle cerebral artery occlusion model were extracted. Statistical analysis was performed using standard mean difference with random effects model of Revman 5.3.
The data of meta-analysis of the 21 studies had suggested that NBP reduced the cerebral infarction volume of middle cerebral artery occlusion model animals compared to the control group significantly [SMD: -3.97, 95%CI: -4.71 to -3.23, P < 0.01; heterogeneity: χ2 = 59.09, df = 20 (P < 0.01); I2 = 66 %].
NBP was effective in experimental ischemic stroke.
Core tip: The systematic review of animal research is of great significance in drug development. This study reports for the first time a systematic review and meta-analysis of the effects of butylphthalide on the volume of cerebral infarction in experimental ischemic stroke.