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Rosas IO, Benitez A, McKinnell JA, Shah R, Waters M, Hunter BD, Jeanfreau R, Tsai L, Neighbors M, Trzaskoma B, de Cassia Castro R, Cai F. Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia. Emerg Infect Dis 2025; 31:1158-1168. [PMID: 40439451 PMCID: PMC12123926 DOI: 10.3201/eid3106.241097] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/02/2025] Open
Abstract
We conducted a multicenter, observational, 12-month follow-up study to identify the extended health burden of severe COVID-19 pneumonia by characterizing long-term sequelae of acute infection in participants previously enrolled in clinical trials for severe COVID-19 pneumonia requiring hospitalization. Overall, 134 (77.5%) of 173 participants completed the study. At 12 months, 51 (29.5%) participants reported cough, 60 (34.7%) reported dyspnea, 56 (32.4%) had residual lung texture abnormalities on high-resolution computed tomography scans, 26 (15.0%) had impaired forced vital capacity, 52 (30.1%) had cognitive impairment, and 77 (44.5%) reported fatigue. Disease severity during acute infection and age were associated with persistent lung texture abnormalities; history of hypertension was associated with higher prevalence of fatigue and more frequent dyspnea and cough; and age and obesity were associated with long-term cognitive impairment. Our findings underscore the long-term health burden of severe COVID-19 pneumonia, reinforcing the importance of regular monitoring in older persons and those with underlying illnesses.
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Cicchetti G, Marano R, Strappa C, Amodeo S, Grimaldi A, Iaccarino L, Scrocca F, Nardini L, Ceccherini A, Del Ciello A, Farchione A, Natale L, Larici AR. New insights into imaging of pulmonary metastases from extra-thoracic neoplasms. LA RADIOLOGIA MEDICA 2025:10.1007/s11547-025-02008-9. [PMID: 40167931 DOI: 10.1007/s11547-025-02008-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Subscribe] [Scholar Register] [Received: 09/24/2024] [Accepted: 03/14/2025] [Indexed: 04/02/2025]
Abstract
The lung is one of the most common sites of metastases from extra-thoracic neoplasms. Lung metastases can show heterogeneous imaging appearance, thus mimicking a wide range of lung diseases, from benign lesions to primary lung cancer. The proper interpretation of pulmonary findings is crucial for prognostic assessment and treatment planning, even to avoid unnecessary procedures and patient anxiety. For this purpose, computed tomography (CT) is one of the most used imaging modalities. In the last decades, cancer patients' population has steadily increased and, due to the widespread application of CT for staging and surveillance, the detection of pulmonary nodules has raised, making their characterization and management an urgent and mostly unsolved problem for both radiologists and clinicians. This review will highlight the pathways of dissemination of extra-thoracic tumours to the lungs and the heterogeneous CT imaging appearance of pulmonary metastases, providing useful clues to properly address the diagnosis. Furthermore, we will deal with the promising applications of radiomics in this field. Finally, a focus on the hot-topic of pulmonary nodule management in patients with extra-thoracic neoplasms (ETNs) will be discussed.
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Affiliation(s)
- Giuseppe Cicchetti
- Advanced Radiology Center, Department of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 8, 00168, Rome, Italy.
| | - Riccardo Marano
- Advanced Radiology Center, Department of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 8, 00168, Rome, Italy
- Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
| | - Cecilia Strappa
- Advanced Radiology Center, Department of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 8, 00168, Rome, Italy
| | - Silvia Amodeo
- Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
| | - Alessandro Grimaldi
- Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
| | - Ludovica Iaccarino
- Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
| | - Francesco Scrocca
- Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
| | - Leonardo Nardini
- Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
| | - Annachiara Ceccherini
- Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
| | - Annemilia Del Ciello
- Advanced Radiology Center, Department of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 8, 00168, Rome, Italy
| | - Alessandra Farchione
- Advanced Radiology Center, Department of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 8, 00168, Rome, Italy
| | - Luigi Natale
- Advanced Radiology Center, Department of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 8, 00168, Rome, Italy
- Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
| | - Anna Rita Larici
- Advanced Radiology Center, Department of Diagnostic Imaging and Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli, 8, 00168, Rome, Italy
- Section of Radiology, Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore, Rome, Italy
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Sugino M, Suzuki M, Nakamura M, Hatano H, Nakanishi M, Misumi K, Nagasaka S, Izumi S, Hojo M, Sugiyama H. Lobectomy for Anomalous Systemic Arterial Supply to the Basal Segment of the Lung in the Second Trimester of a Pregnant Patient with Hemoptysis. Intern Med 2024:4283-24. [PMID: 39522999 DOI: 10.2169/internalmedicine.4283-24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/16/2024] Open
Abstract
An anomalous systemic arterial supply to the basal segment of the lung (ABLL) is a rare congenital vascular anomaly. We herein report a case of ABLL in a 26-year-old pregnant woman with hemoptysis. Contrast-enhanced chest computed tomography (CT) revealed an abnormal vessel branching directly from the descending aorta and circulating to the left lower lobe while showing a normal bronchial anatomy. The patient was therefore diagnosed with ABLL. Maternal safety was a priority, and the patient underwent thoracoscopic left lower lobectomy at 19 weeks' gestation. We concluded that the hemoptysis had been caused by an increased circulating plasma volume during pregnancy.
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Affiliation(s)
- Mio Sugino
- Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
| | - Manabu Suzuki
- Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
| | - Mikako Nakamura
- Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
| | - Hiroto Hatano
- Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
| | - Misao Nakanishi
- Department of Obstetrics and Gynecology, National Center for Global Health and Medicine, Japan
| | - Kento Misumi
- Department of Diagnostic Pathology, National Center for Global Health and Medicine, Japan
| | - Satoshi Nagasaka
- Department of Thoracic Surgery, National Center for Global Health and Medicine, Japan
| | - Shinyu Izumi
- Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
| | - Masayuki Hojo
- Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
| | - Haruhito Sugiyama
- Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan
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Nadem Boueini N, Haage P, Abanador-Kamper N, Kamper L. [Correlation between comorbidities and thoracic CT manifestations of COVID-19 pneumonia]. Med Klin Intensivmed Notfmed 2024; 119:384-390. [PMID: 37747481 PMCID: PMC11130017 DOI: 10.1007/s00063-023-01062-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/17/2023] [Revised: 07/25/2023] [Accepted: 08/10/2023] [Indexed: 09/26/2023]
Abstract
BACKGROUND AND OBJECTIVES Pulmonary manifestation of coronavirus disease 2019 (COVID-19) is described using standardized computed tomography (CT) morphologic criteria. In this study, we investigated possible associations between thoracic CT manifestations in COVID-19 pneumonia and typical comorbidities, as well as clinical course. METHODS We analyzed clinical data and pulmonary imaging of 61 patients with positive PCR test. Pulmonary changes were categorized and reviewed for associations with pre-existing comorbidities and clinical course. RESULTS Compared to patients with atypical infiltrate patterns (2/19, 10.5%), 25 patients with typical infiltrate patterns (25/42, 59.5%) were significantly more likely to receive intensive care (p<0.001). In addition, patients with typical infiltrate patterns were more likely to receive non-invasive ventilation (12/42, 28.6%, p=0.040) and high-flow therapy (8/42, 19%, p=0.041) compared to patients with atypical infiltrate patterns. Mortality was also higher in patients with typical infiltrate patterns, with 15 patients (15/42, 35.7%) dying during follow-up compared to only 1 patient with atypical infiltrate pattern (1/19, 10.5%, p=0.012). No significant association between specific comorbidities and the resulting infiltrate pattern could be demonstrated. CONCLUSIONS Patients with a typical COVID-19 infiltrate pattern are more likely to receive intensive care and show higher mortality rates. Further analysis with larger patient collectives is needed to identify specific risk factors for typical COVID-19 pneumonia.
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Affiliation(s)
- Nima Nadem Boueini
- Private Universität Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58455, Witten, Deutschland.
- Diagnostische und interventionelle Radiologie, HELIOS Universitätsklinikum Wuppertal, Heusnerstr. 40, 42283, Wuppertal, Deutschland.
| | - Patrick Haage
- Private Universität Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58455, Witten, Deutschland
- Diagnostische und interventionelle Radiologie, HELIOS Universitätsklinikum Wuppertal, Heusnerstr. 40, 42283, Wuppertal, Deutschland
| | - Nadine Abanador-Kamper
- Private Universität Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58455, Witten, Deutschland
- Abteilung für Kardiologie, HELIOS Klinikum Elberfeld, Arrenberger Str. 20, 42117, Wuppertal, Deutschland
| | - Lars Kamper
- Private Universität Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58455, Witten, Deutschland
- Diagnostische und interventionelle Radiologie, HELIOS Universitätsklinikum Wuppertal, Heusnerstr. 40, 42283, Wuppertal, Deutschland
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Zheng Y, Ren R, Zuo T, Chen X, Li H, Xie C, Weng M, He C, Xu M, Wang L, Li N, Li X. Prediction of early-phase cytomegalovirus pneumonia in post-stem cell transplantation using a deep learning model. Technol Health Care 2024; 32:3557-3568. [PMID: 39058469 DOI: 10.3233/thc-240597] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 07/28/2024]
Abstract
BACKGROUND Diagnostic challenges exist for CMV pneumonia in post-hematopoietic stem cell transplantation (post-HSCT) patients, despite early-phase radiographic changes. OBJECTIVE The study aims to employ a deep learning model distinguishing CMV pneumonia from COVID-19 pneumonia, community-acquired pneumonia, and normal lungs post-HSCT. METHODS Initially, 6 neural network models were pre-trained with COVID-19 pneumonia, community-acquired pneumonia, and normal lung CT images from Kaggle's COVID multiclass dataset (Dataset A), then Dataset A was combined with the CMV pneumonia images from our center, forming Dataset B. We use a few-shot transfer learning strategy to fine-tune the pre-trained models and evaluate model performance in Dataset B. RESULTS 34 cases of CMV pneumonia were found between January 2018 and December 2022 post-HSCT. Dataset A contained 1681 images of each subgroup from Kaggle. Combined with Dataset A, Dataset B was initially formed by 98 images of CMV pneumonia and normal lung. The optimal model (Xception) achieved an accuracy of 0.9034. Precision, recall, and F1-score all reached 0.9091, with an AUC of 0.9668 in the test set of Dataset B. CONCLUSIONS This framework demonstrates the deep learning model's ability to distinguish rare pneumonia types utilizing a small volume of CT images, facilitating early detection of CMV pneumonia post-HSCT.
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Affiliation(s)
- Yanhua Zheng
- Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- Department of Hematology, The First Hospital of China Medical University, Shenyang, China
| | - Ruilin Ren
- Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
| | - Teng Zuo
- Urology Department, Fourth Affiliated Hospital of China Medical University, Shenyang, China
| | - Xuan Chen
- Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
| | - Hanxuan Li
- Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
| | - Cheng Xie
- Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
| | - Meiling Weng
- Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
| | - Chunxiao He
- Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
| | - Min Xu
- Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
| | - Lili Wang
- Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China
| | - Nainong Li
- Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
| | - Xiaofan Li
- Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
- Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China
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Huang P, Kam KQ, Tan YH, Lee MP, Chan SWB, Lee JH. Trimethoprim-sulfamethoxazole-induced lung injury: a case report. Transl Pediatr 2023; 12:2062-2073. [PMID: 38130590 PMCID: PMC10730970 DOI: 10.21037/tp-23-383] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/10/2023] [Accepted: 10/22/2023] [Indexed: 12/23/2023] Open
Abstract
Background Trimethoprim-sulfamethoxazole (TMP-SMX) is a commonly used antibiotic. While cutaneous adverse drug reactions associated with TMP-SMX are commonly recognized, lung toxicity induced by TMP-SMX is an unusual condition, with scattered reports of hypersensitivity pneumonitis, acute fibrinous organizing pneumonia, interstitial lung disease and acute respiratory distress syndrome. Reports of TMP-SMX-associated drug-induced lung injury (DLI) are rare in the pediatric population and its pathogenesis is not well understood. Diagnosis of DLI remains a challenge, given the wide range of clinical presentations that overlap with other conditions and the lack of diagnostic tests. In this report, we describe a case of TMP-SMX-induced lung injury in an eight-year-old child. Case Description An eight-year-old girl presented in respiratory failure with acute symptoms of shortness of breath, fever, maculopapular rash and vomiting. This was associated with pneumonitis, pneumothorax, pneumomediastinum and subcutaneous emphysema on imaging. She had been on 25 days of TMP-SMX for treatment of Group D Salmonella bacteremia and osteomyelitis that was diagnosed prior to this current presentation. TMP-SMX was discontinued on admission due to concerns of possible drug reaction. Extensive infective, autoimmune and immunologic workup did not reveal the cause of the respiratory failure. Considering the absence of an alternative explanation for her clinical presentation and similarities in clinical courses to other reported cases, she was eventually diagnosed with TMP-SMX-associated DLI. She received a course of corticosteroids with subsequent clinical improvement and was weaned off home oxygen therapy a few months after her discharge from the hospital. Conclusions Diagnosis of DLI can be challenging. The early identification of DLI and discontinuation of culprit drug is essential in its management. Further understanding of the underlying pathophysiology and risk factors for TMP-SMX-associated DLI is required.
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Affiliation(s)
- Peiqi Huang
- Department of Neonatology, KK Women’s & Children’s Hospital, Singapore, Singapore
- Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
| | - Kai-Qian Kam
- Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- Infectious Disease Service, Department of Pediatrics, KK Women’s & Children’s Hospital, Singapore, Singapore
- SingHealth Duke-NUS Pediatrics Academic Clinical Program (ACP), Duke-NUS Medical School, Singapore, Singapore
- Lee Kong Chian School of Medicine, Imperial College London, Nanyang Technological University, Singapore, Singapore
| | - Yi Hua Tan
- Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- SingHealth Duke-NUS Pediatrics Academic Clinical Program (ACP), Duke-NUS Medical School, Singapore, Singapore
- Lee Kong Chian School of Medicine, Imperial College London, Nanyang Technological University, Singapore, Singapore
- Respiratory Medicine Service, Department of Pediatrics, KK Women’s & Children’s Hospital, Singapore, Singapore
| | - May Ping Lee
- Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- SingHealth Duke-NUS Pediatrics Academic Clinical Program (ACP), Duke-NUS Medical School, Singapore, Singapore
- Lee Kong Chian School of Medicine, Imperial College London, Nanyang Technological University, Singapore, Singapore
- Allergy Service, Department of Pediatrics, KK Women’s & Children’s Hospital, Singapore, Singapore
| | - Su-Wan Bianca Chan
- Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- SingHealth Duke-NUS Pediatrics Academic Clinical Program (ACP), Duke-NUS Medical School, Singapore, Singapore
- Lee Kong Chian School of Medicine, Imperial College London, Nanyang Technological University, Singapore, Singapore
- Rheumatology and Immunology Service, Department of Pediatric Subspecialties, KK Women’s and Children’s Hospital, Singapore, Singapore
| | - Jan Hau Lee
- SingHealth Duke-NUS Pediatrics Academic Clinical Program (ACP), Duke-NUS Medical School, Singapore, Singapore
- Children’s Intensive Care Unit, KK Women’s & Children’s Hospital, Singapore, Singapore
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Kanika A, Soldera J. Pulmonary cytomegalovirus infection: A case report and systematic review. World J Meta-Anal 2023; 11:151-166. [DOI: 10.13105/wjma.v11.i5.151] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/09/2023] [Revised: 04/08/2023] [Accepted: 06/09/2023] [Indexed: 06/16/2023] Open
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Peixoto SG, Wolf JM, Glaeser AB, Maccari JG, Nasi LA. Longer length of stay, days between discharge/first readmission, and pulmonary involvement ≥50% increase prevalence of admissions in ICU in unplanned readmissions after COVID-19 hospitalizations. J Med Virol 2022; 94:3750-3756. [PMID: 35506668 PMCID: PMC9347576 DOI: 10.1002/jmv.27792] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2021] [Revised: 02/22/2022] [Accepted: 04/14/2022] [Indexed: 12/13/2022]
Abstract
Hospital readmissions due to COVID‐19 are one of the main concerns for the health system due to risks to the patient's life and increased use of health resources. Studies focusing on this issue are important to understand the risk factors and create strategies to avoid readmissions. We evaluated the readmission of patients with confirmed COVID‐19 in a private hospital in southern Brazil, between March 2020 and 2021. Also, the characteristics and clinical outcomes of patients admitted to the intensive care unit (ICU) and nonadmitted were compared. Poisson regression models with prevalence ratio (PR) with 95% confidence intervals (95% CIs) were applied to confirm the association between variables and ICU admission. Of the 2084 hospitalized patients with COVID‐19, 1806 were discharged alive. Among them, 106 were readmitted for unplanned reasons during one year. Early hospital readmission (≤30 days) occurred in 52.8% of the cases. The main reasons were respiratory, gastroenterological, kidney, and cardiac disease. The median age was 73.0 years old and women correspond to 52.8%. The presence of at least one comorbidity was detected in 87.7% of patients. Hypertension, diabetes, cardiac, and lung disease were more frequent. The ICU admitted patients (n = 43; 40.5%) mostly had 4–5 comorbidities, pulmonary involvement ≥50%, length of stay (LOS), and days between discharge and first readmission. Longer LOS (PR: 3.46; 95% CI: 1.24–5.67), days between discharge/first readmission (PR: 2.21; 95% CI: 1.15–5.88), and pulmonary involvement (≥50%; PR: 1.59; 95% CI: 1.11–3.54) were independently associated with ICU admission. Longer LOS, longer days between discharge/first readmission, and pulmonary involvement (≥50%) were associated with ICU admission in readmitted patients. Readmissions evaluation is pivotal and may help in ensuring safe care transition and postdischarge follow‐up.
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Affiliation(s)
- Sarah G Peixoto
- Internal Medicine, Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil
| | - Jonas M Wolf
- Value Management Office, Medical Manager at Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil
| | - Andressa B Glaeser
- Value Management Office, Medical Manager at Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil
| | - Juçara G Maccari
- Medical Manager, Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil
| | - Luiz A Nasi
- Chief Medical Officer, Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil
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Metastatic Pulmonary Calcification Detected on 18F-FDG PET/CT and 99mTc-MDP Bone Scan. Diagnostics (Basel) 2021; 11:diagnostics11091627. [PMID: 34573968 PMCID: PMC8472040 DOI: 10.3390/diagnostics11091627] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/11/2021] [Revised: 08/27/2021] [Accepted: 09/04/2021] [Indexed: 01/15/2023] Open
Abstract
Metastatic calcification relates to abnormal calcification resulting from hypercalcemia and can affect soft tissues, skeletal muscle, myocardium, lungs, stomach, kidneys, and blood vessels. We describe a case of metastatic pulmonary calcification in a 71-year-old male, images with 18F-fluorodeoxyglucose (FDG) PET/CT and 99mTc- methylene diphosphonate (MDP) bone scan.
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