Patients with chronic kidney disease (CKD), especially end-stage kidney disease (ESKD), are at risk of developing tuberculosis (TB). The prevalence and predictors of LTBI assessed by a high-sensitivity, high-specificity test such as an interferon-gamma release assay (IGRA) has not been thoroughly explored.

All patients with CKD were prospectively recruited from September 2020 to November 2021 and retrospectively reviewed from December 2020 to November 2021. The prevalence of LTBI was determined using IGRA by CKD stage and dialysis type. Predictors of LTBI were assessed by logistic regression analysis.

In total, 199 patients with CKD were enrolled (102 prospectively, 97 retrospectively). Of these, 173 patients were evaluable (mean age, 53 ± 16 years; 44% male). Ninety-five (55%) patients had ESKD and were maintained on renal replacement therapy. Overall, 39 (22.5%) patients had LTBI with a prevalence of 25.0%, 12.5%, 25.0%, 25.0%, and 24.2% among patients with CKD stage 1, 2, 3a, 3b, and ESKD, respectively (p=0.89). Among patients with ESKD, the prevalence of LTBI was higher in those on hemodialysis than in those on peritoneal dialysis (28.9% vs. 5.3%, p=0.03). In the multivariable analysis of patients with ESKD, drinking alcohol was significantly associated with LTBI (odds ratio, 8.51; 95% confidence interval, 1.24–58.38; p=0.029), and hemodialysis was marginally associated with LTBI (odds ratio, 8.14; 95% confidence interval, 0.95–69.91; p=0.056).

In TB-endemic settings, 20% of patients with CKD and 25% of patients with ESKD may have LTBI. Alcohol consumption and hemodialysis can help to identify high-risk patients with ESKD and potentially screen for LBTI.

• mycobacterium tuberculosis
• cell-mediated immunity
• peritoneal dialysis
• hemodialysis
• end-stage kidney disease

• CKD
• diet
• dietary energy intake
• energy expenditure
• indirect calorimetry

• Aged
• Aged, 80 and over
• Basal Metabolism
• Calorimetry, Indirect
• Cross-Sectional Studies
• Energy Intake
• Exercise
• Female
• Humans
• Male
• Middle Aged
• Nutritional Requirements
• Renal Insufficiency, Chronic/metabolism
• Sedentary Behavior

• central nervous system
• cerebral salt-wasting syndrome
• differential diagnosis
• hyponatremia
• syndrome of inappropriate antidiuretic hormone secretion

• Calcific uremic arteriolopathy
• Calcification
• Chronic kidney disease
• Fibroblast growth factor 23
• Kidney transplantation
• Klotho
• Phosphate binders
• Sevelamer
• Uremia

Introduction: For diagnosing of specific types of bone lesions in hemodialysis (HD) patients, it is necessary to conduct a bone biopsy as the gold standard method. However, it is an invasive procedure. While different markers have been suggested as alternative methods, none of them has been selected. The frequency of hip fractures is 80 fold in HD patients who have two-fold mortality as compared with general population.

Objectives: Recently, serum leptin has been suggested as a bone density marker. This study tries to confirm this proposal.

Patients and Methods: In this study about 104 HD patients (53.8% male and 46.2% female) were enrolled. The average age was 38.28±7.89 years. Serum leptin, bone alkaline phosphatase, intact parathyroid hormone (iPTH), 25(OH)D, calcium, phosphorus and bone mineral density (BMD) (at the femoral neck and lumbar spine, as measured by dual-energy x-ray absorptiometry [DXA]) were assessed.

Results: Analysis by polynomial regression revealed no correlation between BMD Z-score at two points and serum leptin level. According to the thresholds of 25 ng/mL and 18-24 ng/mL in some studies, we detected 25 ng/mL as the threshold in our patients. Under this threshold, the leptin effect on bone mass was negative, and above the threshold of 25 ng/mL, we found leptin had positive effect on bone mass.

Conclusion: In this investigation, we found, leptin has a bimodal effect on bone mass. Cortical bones assessment may be a better option for assessment.

• Bone mineral density
• Dual-energy x-ray absorptiometry
• Hemodialysis
• Leptin

• Cryoglobulin characterization
• Cryoglobulin detection
• Cryoglobulinemic glomerulonephritis
• Essential mixed cryoglobulinemia
• Hepatitis C virus
• Renal manifestations