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For: Xu J, Hu C, Cao HL, Zhang ML, Ye S, Zheng SS, Wang WL. Meta-Analysis of Laparoscopic versus Open Hepatectomy for Live Liver Donors. PLoS One 2016;11:e0165319. [PMID: 27788201 PMCID: PMC5082914 DOI: 10.1371/journal.pone.0165319] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/27/2016] [Accepted: 10/09/2016] [Indexed: 12/19/2022] Open

For:	Xu J, Hu C, Cao HL, Zhang ML, Ye S, Zheng SS, Wang WL. Meta-Analysis of Laparoscopic versus Open Hepatectomy for Live Liver Donors. PLoS One 2016;11:e0165319. [PMID: 27788201 PMCID: PMC5082914 DOI: 10.1371/journal.pone.0165319] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/27/2016] [Accepted: 10/09/2016] [Indexed: 12/19/2022] Open

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Cited by Other Article(s)

Xu X, Lv T, Xu G, Wei Q, Ling Q, Wei L, Li J, Zhang J, Cai Y, Cai J, Chen G, Chen Z, Chen Z, Cheng Y, Dou J, Du S, Du C, Fu Z, Guo Z, Gao L, He X, He Q, Huang L, Huang J, Huo F, Jia C, Jin C, Jiang W, Jiang J, Jiao Z, Jing HE, Lang R, Li B, Li L, Li N, Li Q, Li W, Li Y, Li G, Liu J, Liu L, Liu J, Liu L, Liu Z, Lu S, Lu Q, Lv L, Lv Y, Lv G, Liang T, Ming Y, Peng Z, Ran J, Shi J, Sun B, Sun C, Sun X, Sun Y, Si Z, Shao Y, Song J, Tao K, Teng M, Wan Y, Wan X, Wang L, Wen H, Wu G, Wu J, Wu X, Wu Z, Wei L, Xu J, Xu J, Yang Y, Yang H, Yang Z, Yang Z, Yang J, Ye Q, Yi S, Zhou J, Zhang F, Zhang L, Zhang M, Zhang W, Zhang L, Zhang S, Zhao S, Zheng H, Zhong L, Zhu H, Zhu J, Zhu X, Zhu Z, Wu H, Guo W, Wang Z, Xu X, Yang J, et alXu X, Lv T, Xu G, Wei Q, Ling Q, Wei L, Li J, Zhang J, Cai Y, Cai J, Chen G, Chen Z, Chen Z, Cheng Y, Dou J, Du S, Du C, Fu Z, Guo Z, Gao L, He X, He Q, Huang L, Huang J, Huo F, Jia C, Jin C, Jiang W, Jiang J, Jiao Z, Jing HE, Lang R, Li B, Li L, Li N, Li Q, Li W, Li Y, Li G, Liu J, Liu L, Liu J, Liu L, Liu Z, Lu S, Lu Q, Lv L, Lv Y, Lv G, Liang T, Ming Y, Peng Z, Ran J, Shi J, Sun B, Sun C, Sun X, Sun Y, Si Z, Shao Y, Song J, Tao K, Teng M, Wan Y, Wan X, Wang L, Wen H, Wu G, Wu J, Wu X, Wu Z, Wei L, Xu J, Xu J, Yang Y, Yang H, Yang Z, Yang Z, Yang J, Ye Q, Yi S, Zhou J, Zhang F, Zhang L, Zhang M, Zhang W, Zhang L, Zhang S, Zhao S, Zheng H, Zhong L, Zhu H, Zhu J, Zhu X, Zhu Z, Wu H, Guo W, Wang Z, Xu X, Yang J, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association, Branch of Organ Transplant of Chinese Medical Association. Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition). Hepatobiliary Surg Nutr 2024;13:919-936. [PMID: 39669074 PMCID: PMC11634423 DOI: 10.21037/hbsn-24-329] [Show More Authors] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/24/2024] [Accepted: 09/14/2024] [Indexed: 12/14/2024]

Abstract

BACKGROUND

Minimally invasive surgeries are increasingly central to modern medicine, particularly in liver transplantation. These techniques, which offer reduced trauma, precise operations, minimal bleeding, and swift recovery, are, however, unevenly adopted across China. Only a limited number of centers routinely perform minimally invasive donor hepatectomies, indicating a significant imbalance in the development and application of these advanced procedures. Additionally, there lacks a set of standardized guidelines that are tailored to meet China's unique healthcare challenges and conditions.

METHODS

In August 2023, the Branch of Organ Transplant of Chinese Medical Association and the Branch of Organ Transplant Physicians of Chinese Medical Doctor Association convened a group of national liver transplantation experts to establish a guideline development committee. This committee conducted a thorough review of relevant literature, evaluated existing guidelines and consensus, and assessed factors such as the evidence base, patient preferences, and the cost-effectiveness of interventions within China. After multiple rounds of discussions, both online and offline, the committee finalized the guidelines.

RESULTS

This collaborative effort led to the creation of the "Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition)". These guidelines address crucial aspects such as the safety and advantages of minimally invasive surgery for living donor liver transplantation, donor selection criteria, anesthesia strategies, surgical technical details, and learning curves associated with these procedures, resulting in a comprehensive set of 26 recommendations.

CONCLUSIONS

The formulation of these guidelines represents a significant advancement towards standardizing minimally invasive liver transplantation surgeries in China. They are designed to enhance outcomes for both donors and recipients by synthesizing expert consensus with contemporary research and clinical practices. Moreover, they serve as a crucial reference for surgeons and medical institutions, promoting the refinement and adoption of minimally invasive surgical techniques in liver transplantation.

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Affiliation(s)

Xi Xu Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China
Tao Lv Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China
Gang Xu Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China
Qiang Wei Zhejiang University School of Medicine, Hangzhou, China
Qi Ling Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Lin Wei Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Jianhua Li Liver Transplantation Center, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China
Jiakai Zhang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Yang Cai Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, China
Jinzhen Cai Organ Transplantation Center, Affiliated Hospital of Qingdao University, Qingdao, China
Guihua Chen Department of Hepatic Surgery and Liver Transplantation Center of The Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, China
Zhishui Chen Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Zhonghua Chen Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Ying Cheng Department of Transplantation and General Surgery, First Hospital of China Medical University, Shenyang, China
Jian Dou Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China
Shunda Du Department of Liver Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Chengyou Du Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Zhiren Fu Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Zhiyong Guo Organ Transplant Centre, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Lianghui Gao Department of Hepatobiliary & Pancreatic Surgery, First Affiliated Hospital, Hainan Medical University, Haikou, China
Xiaoshun He Organ Transplant Centre, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Qiang He Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Lei Huang Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, China
Jianzhao Huang Department of Hepatobiliary Surgery, Guizhou Provincial People’s Hospital, Guiyang, China
Feng Huo Department of Hepatobiliary Surgery and Liver Transplant Center, General Hospital of Southern Theater Command, Guangzhou, China
Changku Jia Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, China
Chen Jin Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China
Wentao Jiang Department of Liver Transplantation, Tianjin First Central Hospital, Tianjin, China
Jipin Jiang Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Zuoyi Jiao Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, China
Hong-En Jing Department of Hepatobiliary & Pancreatic Surgery, Affiliated Hospital of Qinghai University, Xining, China
Ren Lang Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Bo Li Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, China
Li Li Department of Hepato-Biliary-Pancreatic Surgery, The First People’s Hospital of Kunming, The Affiliated Calmette Hospital of Kunming Medical University, Kunming, China
Ning Li General Surgery Center, Beijing Youan Hospital, Capital Medical University, Beijing, China
Qiyong Li Department of Hepatobiliary and Pancreatic Surgery, Department of Liver Transplantation, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, China
Wengang Li Department of Hepatobiliary and Pancreatic & Organ Transplantation Surgery, Xiang’an Hospital, School of Medicine, Xiamen University, Xiamen, China
Yumin Li Key Laboratory of Digestive System Tumor of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China
Guangming Li General Surgery Center, Beijing Youan Hospital, Capital Medical University, Beijing, China
Jun Liu Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
Lei Liu The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China
Jingfeng Liu Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China
Lianxin Liu Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Hefei, China
Zuojin Liu Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Shichun Lu Institute and Hospital of Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China
Qian Lu Center of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
Ling Lv Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Yi Lv Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
Guoyue Lv Department of General Surgery, The First Hospital of Jilin University, Changchun, China
Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Yingzi Ming Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China
Zhihai Peng Department of Hepatobiliary and Pancreatic & Organ Transplantation Surgery, Xiang’an Hospital, School of Medicine, Xiamen University, Xiamen, China
Jianghua Ran Department of Hepato-Biliary-Pancreatic Surgery, The First People’s Hospital of Kunming, The Affiliated Calmette Hospital of Kunming Medical University, Kunming, China
Jun Shi Department of General Surgery, Ji’an Hospital, Shanghai East Hospital, School of Medicine, Tongji University, Ji’an, China
Beicheng Sun Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China
Chengyi Sun Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China
Xuyong Sun Transplant Medical Center, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China
Yuling Sun Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zhongzhou Si Department of Liver Transplant, The Second Xiangya Hospital, Central South University, Changsha, China
Yingmei Shao Department of Hepatobiliary & Hydatid Diseases, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
Jiulin Song Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China
Kaishan Tao Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Mujian Teng Department of Liver Transplantation and Hepatic Surgery, Cheeloo College of Medicine, Shandong University, Shandong Qianfoshan Hospital, Jinan, China
Yunle Wan Department of Hepatobiliary, Pancreatic and Splenic Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Xueshuai Wan Department of Liver Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Liming Wang Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China
Hao Wen Department of Hepatobiliary & Hydatid Diseases, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
Gang Wu Department of Transplantation and General Surgery, First Hospital of China Medical University, Shenyang, China
Jian Wu Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Xiangwei Wu Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shihezi University, Shihezi, China
Zhongjun Wu Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Lai Wei Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Jian Xu Hepatobiliary and Liver Transplantation Department of Hainan Digestive Disease Center, Institute of Clinical Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, China
Jun Xu Department of Hepatobiliary and Pancreatic Surgery and Liver Transplant Center, The First Hospital of Shanxi Medical University, Taiyuan, China
Yang Yang Department of Hepatic Surgery and Liver Transplantation Center of The Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, China
Hongji Yang Organ Transplantation Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Zhanyu Yang Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, Beijing, China
Zhaoxu Yang Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China
Jian Yang Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China
Qifa Ye Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China
Shuhong Yi Department of Hepatic Surgery and Liver Transplantation Center of The Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, China
Jian Zhou Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai, China
Feng Zhang Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Lei Zhang Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China
Min Zhang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Wu Zhang Department of Hepatobiliary and Pancreatic Surgery, Department of Liver Transplantation, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, China
Leida Zhang Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China
Shuijun Zhang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Shunyun Zhao Department of Hepatic Hydatidosis, Qinghai Provincial People’s Hospital, Xining, China
Hong Zheng Organ Transplant Department, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China
Lin Zhong Department of General Surgery, The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China
Haitao Zhu Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China
Jiye Zhu Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, China
Xiaofeng Zhu Organ Transplant Centre, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
Zhijun Zhu Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Hong Wu Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China
Wenzhi Guo Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zhengxin Wang Liver Transplantation Center, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China
Xiao Xu Zhejiang University School of Medicine, Hangzhou, China Hangzhou Medical College, Hangzhou, China
Jiayin Yang Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China
Branch of Organ Transplant Physicians of Chinese Medical Doctor Association Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China Zhejiang University School of Medicine, Hangzhou, China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China Liver Transplantation Center, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, China Organ Transplantation Center, Affiliated Hospital of Qingdao University, Qingdao, China Department of Hepatic Surgery and Liver Transplantation Center of The Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, China Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Transplantation and General Surgery, First Hospital of China Medical University, Shenyang, China Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China Department of Liver Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Organ Transplant Centre, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of Hepatobiliary & Pancreatic Surgery, First Affiliated Hospital, Hainan Medical University, Haikou, China Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, China Department of Hepatobiliary Surgery, Guizhou Provincial People’s Hospital, Guiyang, China Department of Hepatobiliary Surgery and Liver Transplant Center, General Hospital of Southern Theater Command, Guangzhou, China Department of Liver Transplantation, Tianjin First Central Hospital, Tianjin, China Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, China Department of Hepatobiliary & Pancreatic Surgery, Affiliated Hospital of Qinghai University, Xining, China Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, China Department of Hepato-Biliary-Pancreatic Surgery, The First People’s Hospital of Kunming, The Affiliated Calmette Hospital of Kunming Medical University, Kunming, China General Surgery Center, Beijing Youan Hospital, Capital Medical University, Beijing, China Department of Hepatobiliary and Pancreatic Surgery, Department of Liver Transplantation, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, China Department of Hepatobiliary and Pancreatic & Organ Transplantation Surgery, Xiang’an Hospital, School of Medicine, Xiamen University, Xiamen, China Key Laboratory of Digestive System Tumor of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Hefei, China Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China Institute and Hospital of Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China Center of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of General Surgery, The First Hospital of Jilin University, Changchun, China Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China Department of General Surgery, Ji’an Hospital, Shanghai East Hospital, School of Medicine, Tongji University, Ji’an, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China Transplant Medical Center, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China Department of Liver Transplant, The Second Xiangya Hospital, Central South University, Changsha, China Department of Hepatobiliary & Hydatid Diseases, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China Department of Liver Transplantation and Hepatic Surgery, Cheeloo College of Medicine, Shandong University, Shandong Qianfoshan Hospital, Jinan, China Department of Hepatobiliary, Pancreatic and Splenic Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shihezi University, Shihezi, China Hepatobiliary and Liver Transplantation Department of Hainan Digestive Disease Center, Institute of Clinical Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, China Department of Hepatobiliary and Pancreatic Surgery and Liver Transplant Center, The First Hospital of Shanxi Medical University, Taiyuan, China Organ Transplantation Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, Beijing, China Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai, China Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China Department of Hepatic Hydatidosis, Qinghai Provincial People’s Hospital, Xining, China Organ Transplant Department, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China Department of General Surgery, The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China Hangzhou Medical College, Hangzhou, China
Branch of Organ Transplant of Chinese Medical Association Liver Transplant Center, Department of General Surgery, West China Hospital of Sichuan University, Chengdu, China Laboratory of Liver Transplantation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital of Sichuan University, Chengdu, China Zhejiang University School of Medicine, Hangzhou, China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China Liver Transplantation Center, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, China Organ Transplantation Center, Affiliated Hospital of Qingdao University, Qingdao, China Department of Hepatic Surgery and Liver Transplantation Center of The Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, China Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Transplantation and General Surgery, First Hospital of China Medical University, Shenyang, China Department of Hepatobiliary Surgery, Hebei Medical University Third Hospital, Shijiazhuang, China Department of Liver Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Organ Transplant Centre, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of Hepatobiliary & Pancreatic Surgery, First Affiliated Hospital, Hainan Medical University, Haikou, China Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, China Department of Hepatobiliary Surgery, Guizhou Provincial People’s Hospital, Guiyang, China Department of Hepatobiliary Surgery and Liver Transplant Center, General Hospital of Southern Theater Command, Guangzhou, China Department of Liver Transplantation, Tianjin First Central Hospital, Tianjin, China Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, China Department of Hepatobiliary & Pancreatic Surgery, Affiliated Hospital of Qinghai University, Xining, China Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, China Department of Hepato-Biliary-Pancreatic Surgery, The First People’s Hospital of Kunming, The Affiliated Calmette Hospital of Kunming Medical University, Kunming, China General Surgery Center, Beijing Youan Hospital, Capital Medical University, Beijing, China Department of Hepatobiliary and Pancreatic Surgery, Department of Liver Transplantation, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, China Department of Hepatobiliary and Pancreatic & Organ Transplantation Surgery, Xiang’an Hospital, School of Medicine, Xiamen University, Xiamen, China Key Laboratory of Digestive System Tumor of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China Innovation Center for Cancer Research, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Hefei, China Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China Institute and Hospital of Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, Beijing, China Center of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of General Surgery, The First Hospital of Jilin University, Changchun, China Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China Department of General Surgery, Ji’an Hospital, Shanghai East Hospital, School of Medicine, Tongji University, Ji’an, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China Transplant Medical Center, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China Department of Liver Transplant, The Second Xiangya Hospital, Central South University, Changsha, China Department of Hepatobiliary & Hydatid Diseases, Digestive & Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China Department of Liver Transplantation and Hepatic Surgery, Cheeloo College of Medicine, Shandong University, Shandong Qianfoshan Hospital, Jinan, China Department of Hepatobiliary, Pancreatic and Splenic Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shihezi University, Shihezi, China Hepatobiliary and Liver Transplantation Department of Hainan Digestive Disease Center, Institute of Clinical Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, China Department of Hepatobiliary and Pancreatic Surgery and Liver Transplant Center, The First Hospital of Shanxi Medical University, Taiyuan, China Organ Transplantation Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China Faculty of Hepato-Pancreato-Biliary Surgery, Chinese PLA General Hospital, Beijing, China Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China Department of Liver Surgery, Zhongshan Hospital, Fudan University, Liver Cancer Institute, Fudan University, Shanghai, China Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China Department of Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China Department of Hepatic Hydatidosis, Qinghai Provincial People’s Hospital, Xining, China Organ Transplant Department, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China Department of General Surgery, The Third People’s Hospital of Shenzhen, The Second Hospital Affiliated of Southern University of Science and Technology, Shenzhen, China Hangzhou Medical College, Hangzhou, China

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Liu S, Song B, Zhang L, Li X, Cui L. Clinical Trial Study Protocol: A Prospective Blinded, Randomized, Controlled Clinical Trial Protocol to Assess the Efficacy of Ultrasound-Guided Transversus Abdominis Plane Block on Postoperative Analgesia and Recovery Quality in Laparoscopic Donor Hepatectomy. J Pain Res 2024;17:3401-3408. [PMID: 39464411 PMCID: PMC11512518 DOI: 10.2147/jpr.s476966] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/06/2024] [Accepted: 10/18/2024] [Indexed: 10/29/2024] Open

Ziogas IA, Kakos CD, Moris DP, Kaltenmeier C, Tsoulfas G, Montenovo MI, Alexopoulos SP, Geller DA, Pomfret EA. Systematic review and meta-analysis of open versus laparoscopy-assisted versus pure laparoscopic versus robotic living donor hepatectomy. Liver Transpl 2023;29:1063-1078. [PMID: 36866856 DOI: 10.1097/lvt.0000000000000115] [Citation(s) in RCA: 10] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/18/2022] [Accepted: 02/13/2023] [Indexed: 03/04/2023]

Kwon JH, Ko JS, Kim HJ, Han S, Gwak MS, Kim GS, Lee SY, Wi W. Comparison of the analgesic effect of intrathecal morphine between laparoscopic and open living donor hepatectomy: Propensity score matching analysis. Medicine (Baltimore) 2023;102:e34627. [PMID: 37657001 PMCID: PMC10476809 DOI: 10.1097/md.0000000000034627] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/05/2023] [Accepted: 07/14/2023] [Indexed: 09/03/2023] Open

Abstract

Laparoscopic donor hepatectomy is being increasingly adopted in transplant programs due to its numerous advantages. However, the role of intrathecal morphine (ITM) in laparoscopic donor hepatectomy has not been thoroughly investigated. This study aimed to compare the analgesic effects and safety of ITM between laparoscopic and open donor hepatectomy. This retrospective study included 742 donors who underwent hepatectomy with ITM between April 2007 and June 2019. Among them, 168 and 574 donors underwent laparoscopic hepatectomy (LH) and open hepatectomy (OH), respectively. Propensity score matching yielded two comparable groups of 168 donors each. The primary endpoint was the incidence of moderate-to-severe pain (maximum numerical rating scale [NRS] pain score ≥ 4) within 24 postoperative hours. The LH group had a significantly lower incidence of moderate-to-severe pain within 24 postoperative hours than the OH group (16.1% vs 64.3%, P < .001). Moreover, the cumulative rescue intravenous opioids (in morphine-equivalent dose) on postoperative day (POD) 1 was lower in the LH group than in the OH group (3.3 [0-8.3] mg vs 10 [3.3-17.3] mg; P < .001). There were no significant between-group differences in the incidence of respiratory depression (2.4% vs 0.6%; P = .371) and prescriptions for pruritus (14.3% vs 15.5%; P = .878). However, the prescriptions for postoperative nausea and vomiting (PONV) was significantly higher in the LH group than in the OH group (64.9% vs 41.7%; P < .001). The predictors of antiemetic agent prescription included the use of laparoscopic procedure (adjusted odds ratio [OR], 2.05; 95% confidence interval [CI], 1.11-3.79; P = .021) and female sex (adjusted OR, 5.63; 95% CI, 3.19-9.92; P < .001). Preoperative ITM administration resulted in a significantly lower incidence of moderate-to-severe pain within 24 postoperative hours after laparoscopic donor hepatectomy than after open donor hepatectomy.

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Mu C, Chen C, Wan J, Chen G, Hu J, Wen T. Minimally Invasive Donors Right Hepatectomy versus Open Donors Right Hepatectomy: A Meta-Analysis. J Clin Med 2023;12:jcm12082904. [PMID: 37109241 PMCID: PMC10146341 DOI: 10.3390/jcm12082904] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/27/2022] [Revised: 03/06/2023] [Accepted: 04/03/2023] [Indexed: 04/29/2023] Open

Cheah YL, Heimbach J, Kwon CHD, Pomposelli J, Rudow DL, Broering D, Spiro M, Raptis DA, Roberts JP. Influence of surgical technique in donor hepatectomy on immediate and short-term living donor outcomes - A systematic review of the literature, meta-analysis, and expert panel recommendations. Clin Transplant 2022;36:e14703. [PMID: 35538019 DOI: 10.1111/ctr.14703] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/12/2022] [Accepted: 02/28/2022] [Indexed: 02/04/2023]

Abstract

BACKGROUND

There are currently no guidelines pertaining to ERAS pathways in living donor hepatectomy.

OBJECTIVES

The aim of this study was to identify whether surgical technique influences immediate and short-term outcomes after living liver donation surgery.

DATA SOURCES

Ovid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central.

METHODS

Systematic review and meta-analysis following PRISMA guidelines and recommendations using the GRADE approach derived from an international expert panel (CRD42021260707). Endpoints were mortality, overall complications, serious complications, bile eaks, pulmonary complications, estimated blood loss and length of stay.

RESULTS

Of the 2410 screened articles, 21 articles were included for final analysis; three observational, 13 retrospective cohort, four prospective cohort studies, and one randomized trial. Overall complications were higher with right versus left hepatectomy (26.8% vs. 20.8%; OR 1.4, P = .010). Donors after left hepatectomy had shorter length of stay (MD 1.4 days) compared to right hepatectomy. There was no difference in outcomes after right donor hepatectomy with versus without middle hepatic vein. We had limited data on the influence of incision type and minimally invasive approaches on living donor outcomes, and no data on the effect of operative time on donor outcomes.

CONCLUSIONS

Left donor hepatectomy should be preferred over right hepatectomy, as it is related to improved donor short-term outcomes (QOE; Moderate | Grade of Recommendation; Strong). Right donor hepatectomy with or without MHV has equivalent outcomes (QOE; Moderate | Grade of Recommendation; Strong); no preference is recommended, decision should be based on program's experience and expertise. No difference in outcomes was observed related to incision type, minimally invasive vs. open (QOE; Low | Grade of Recommendation; Weak); no preference can be recommended.

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Cassese G, Han HS, Lee B, Lee HW, Cho JY, Troisi R. Leaping the Boundaries in Laparoscopic Liver Surgery for Hepatocellular Carcinoma. Cancers (Basel) 2022;14:2012. [PMID: 35454921 PMCID: PMC9028003 DOI: 10.3390/cancers14082012] [Citation(s) in RCA: 9] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/01/2022] [Revised: 04/07/2022] [Accepted: 04/12/2022] [Indexed: 02/08/2023] Open

Akbulut S, Sahin TT. Comment on "Minimally Invasive Donor Hepatectomy for Adult Living Donor Liver Transplantation: An International, Multi-institutional Evaluation of Safety, Efficacy, and Early Outcomes". Ann Surg 2021;274:e771-e772. [PMID: 33201100 DOI: 10.1097/sla.0000000000004281] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/07/2023]

Kabir T, Tan ZZ, Syn NL, Wu E, Lin JD, Zhao JJ, Tan AYH, Hui Y, Kam JH, Goh BKP. Laparoscopic versus open resection of hepatocellular carcinoma in patients with cirrhosis: a meta-analysis. Br J Surg 2021;109:21-29. [PMID: 34757385 DOI: 10.1093/bjs/znab376] [Citation(s) in RCA: 66] [Impact Index Per Article: 16.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/10/2021] [Accepted: 09/29/2021] [Indexed: 02/07/2023]

Abstract

BACKGROUND

The exact role of laparoscopic liver resection (LLR) in patients with hepatocellular carcinoma (HCC) and underlying liver cirrhosis (LC) is not well defined. In this meta-analysis, both long- and short-term outcomes following LLR versus open liver resection (OLR) were analysed.

METHODS

PubMed, EMBASE, Scopus and Web of Science databases were searched systematically for randomised controlled trials (RCTs) and propensity-score matched (PSM) studies reporting outcomes of LLR versus OLR of HCC in patients with cirrhosis. Primary outcome was overall survival (OS). This was analysed using one-stage (individual participant data meta-analysis) and two-stage (aggregate data meta-analysis) approaches. Secondary outcomes were operation duration, blood loss, blood transfusion, Pringle manoeuvre utilization, overall and major complications, length of hospital stay (LOHS), 90-day mortality and R0 resection rates.

RESULTS

Eleven studies comprising 1618 patients (690 LLR versus 928 OLR) were included for analysis. In the one-stage meta-analysis, an approximately 18.7 per cent lower hazard rate (HR) of death in the LLR group (random effects: HR 0.81, 95 per cent confidence interval [C.I.] 0.68 to 0.96; P = 0.018) was observed. Two-stage meta-analysis resulted in a pooled HR of 0.84 (95 per cent C.I. 0.74 to 0.96; P = 0.01) in the overall LLR cohort. This indicated a 16-26 per cent reduction in the HR of death for patients with HCC and cirrhosis who underwent LLR. For secondary outcomes, LLR was associated with less blood loss (mean difference [MD] -99 ml, 95 per cent C.I. -182 to -16 ml), reduced overall complications (odds ratio 0.49, 95 per cent C.I. 0.37 to 0.66) and major complications (odds ratio 0.45, 95 per cent C.I. 0.26 to 0.79), and shorter LOHS (MD -3.22 days, 95 per cent C.I. -4.38 to -2.06 days).

CONCLUSION

Laparoscopic resection of HCC in patients with cirrhosis is associated with improved survival and perioperative outcomes.

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Rammohan A, Rela M. Robotic donor hepatectomy: Are we there yet? World J Gastrointest Surg 2021;13:668-677. [PMID: 34354800 PMCID: PMC8316848 DOI: 10.4240/wjgs.v13.i7.668] [Citation(s) in RCA: 12] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/08/2021] [Revised: 04/09/2021] [Accepted: 06/16/2021] [Indexed: 02/06/2023] Open

Xiao F, Sun LY, Wei L, Zeng ZG, Qu W, Liu Y, Zhang HM, Zhu ZJ. Cholangiojejunostomy for multiple biliary ducts in living donor liver transplantation: A case report. World J Clin Cases 2021;9:2649-2654. [PMID: 33889632 PMCID: PMC8040162 DOI: 10.12998/wjcc.v9.i11.2649] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/12/2020] [Revised: 12/26/2020] [Accepted: 01/28/2021] [Indexed: 02/06/2023] Open

Abstract

BACKGROUND

Laparoscopic living donor hepatectomy (LLDH) has been successfully carried out in several transplant centers. Biliary reconstruction is key in living donor liver transplantation (LDLT). Reliable biliary reconstruction can effectively prevent postoperative biliary stricture and leakage. Although preoperative magnetic resonance cholangiopancreatography and intraoperative indocyanine green cholangiography have been shown to be helpful in determining optimal division points, biliary variability and limitations associated with LLDH, multiple biliary tracts are often encountered during surgery, which inhibits biliary reconstruction. A reliable cholangiojejunostomy for multiple biliary ducts has been utilized in LDLT. This procedure provides a reference for multiple biliary reconstructions after LLDH.

CASE SUMMARY

A 2-year-old girl diagnosed with ornithine transcarbamylase deficiency required liver transplantation. Due to the scarcity of deceased donors, she was put on the waiting list for LDLT. Her father was a suitable donor; however, after a rigorous evaluation, preoperative magnetic resonance cholangiopancreatography examination of the donor indicated the possibility of multivessel variation in the biliary tract. Therefore, a laparoscopic left lateral section was performed on the donor, which met the estimated graft-to-recipient weight ratio. Under intraoperative indocyanine green cholangiography, 4 biliary tracts were confirmed in the graft. It was difficult to reform the intrahepatic bile ducts due to their openings of more than 5 mm. A reliable cholangiojejunostomy was, therefore, utilized: Suture of the jejunum to the adjacent liver was performed around the bile duct openings with 6/0 absorbable sutures. At the last follow-up (1 year after surgery), the patient was complication-free.

CONCLUSION

Intrahepatic cholangiojejunostomy is reliable for multiple biliary ducts after LLDH in LDLT.

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Cherqui D, Ciria R, Kwon CHD, Kim KH, Broering D, Wakabayashi G, Samstein B, Troisi RI, Han HS, Rotellar F, Soubrane O, Briceño J, Alconchel F, Ayllón MD, Berardi G, Cauchy F, Luque IG, Hong SK, Yoon YY, Egawa H, Lerut J, Lo CM, Rela M, Sapisochin G, Suh KS. Expert Consensus Guidelines on Minimally Invasive Donor Hepatectomy for Living Donor Liver Transplantation From Innovation to Implementation: A Joint Initiative From the International Laparoscopic Liver Society (ILLS) and the Asian-Pacific Hepato-Pancreato-Biliary Association (A-PHPBA). Ann Surg 2021;273:96-108. [PMID: 33332874 DOI: 10.1097/sla.0000000000004475] [Citation(s) in RCA: 64] [Impact Index Per Article: 16.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/13/2022]

Affiliation(s)

Daniel Cherqui AP-HP, Hepatobiliary Center, Paul Brousse Hospital, Université Paris Saclay, Villejuif, France
Ruben Ciria Unit of Hepatobiliary Surgery and Liver Transplantation. University Hospital Reina Sofía, Cordoba, Spain
Choon Hyuck David Kwon Department of General Surgery, Digestive Disease & Surgery Institute, Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Ki-Hun Kim Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Dieter Broering Organ Transplant Center, King Faisal Specialist Hospital and Research Center, Al Faisal University, Riyadh, KSA
Go Wakabayashi Center for Advanced Treatment of Hepatobiliary and Pancreatic Diseases, Ageo Central General Hospital, Ageo, Japan
Benjamin Samstein Department of Surgery, Division of Liver Transplantation and Hepatobiliary Surgery, Weill Cornell Medical College, New York, New York
Roberto I Troisi Organ Transplant Center, King Faisal Specialist Hospital and Research Center, Al Faisal University, Riyadh, KSA Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy; Department of Human Structure and Repair, Ghent University, Belgium
Ho Seong Han Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
Fernando Rotellar Department of General Surgery, Clínica Universidad de Navarra, School of Medicine, University of Navarra, Pamplona, Spain
Olivier Soubrane Department of Hepatopancreatobiliary Surgery and Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris and Université de Paris, Clichy, France
Javier Briceño Unit of Hepatobiliary Surgery and Liver Transplantation. University Hospital Reina Sofía, Cordoba, Spain
Felipe Alconchel Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain; Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Murcia, Spain
María Dolores Ayllón Unit of Hepatobiliary Surgery and Liver Transplantation. University Hospital Reina Sofía, Cordoba, Spain
Giammauro Berardi Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy; Department of Human Structure and Repair, Ghent University, Belgium
Francois Cauchy Department of Hepatopancreatobiliary Surgery and Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris and Université de Paris, Clichy, France
Irene Gómez Luque Unit of Hepatobiliary Surgery and Liver Transplantation. University Hospital Reina Sofía, Cordoba, Spain
Suk Kyun Hong Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea
Young-Yin Yoon Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Hiroto Egawa Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University
Jan Lerut Institut de Recherche Expérimentale et Clinique Université Catholique de Louvain Brussels, Belgium
Chung-Mau Lo Department of Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China
Mohamed Rela The Institute of Liver Disease and Transplantation, Dr. Rela Institute and Medical Center, Bharat Institute of Higher Education and Research, Chennai, India Institute of Liver Studies, King's College Hospital, London, UK
Gonzalo Sapisochin Multi-Organ Transplant and HPB Surgical Oncology, Division of General Surgery, University Health Network, Department of Surgery, University of Toronto, Canada
Kyung-Suk Suh Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea

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Yin X, Luo D, Huang Y, Huang M. Advantages of laparoscopic left hemihepatectomy: A meta-analysis. Medicine (Baltimore) 2019;98:e15929. [PMID: 31169712 PMCID: PMC6571277 DOI: 10.1097/md.0000000000015929] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/01/2018] [Revised: 05/04/2019] [Accepted: 05/10/2019] [Indexed: 12/28/2022] Open

Pure laparoscopic living donor hepatectomy using the Glissonean pedicle approach (with video). Surg Endosc 2019;33:2704-2709. [DOI: 10.1007/s00464-019-06818-7] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/06/2019] [Accepted: 04/30/2019] [Indexed: 12/19/2022]

Vijai NA, Senthilnathan P, Annamaneni V, Sabnis SC, Soin AS, Palanivelu C. Laparoscopic donor hepatectomy: First experience from Indian sub-continent. J Minim Access Surg 2018;15:170-173. [PMID: 30106023 PMCID: PMC6438070 DOI: 10.4103/jmas.jmas_134_18] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/05/2022] Open

Eguchi S, Soyama A, Hara T, Natsuda K, Okada S, Hamada T, Kosaka T, Ono S, Adachi T, Hidaka M, Takatsuki M. Standardized hybrid living donor hemihepatectomy in adult-to-adult living donor liver transplantation. Liver Transpl 2018;24:363-368. [PMID: 29194959 DOI: 10.1002/lt.24990] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/27/2017] [Revised: 10/26/2017] [Accepted: 11/26/2017] [Indexed: 02/07/2023]

Chu H, Cao G, Tang Y, Du X, Min X, Wan C. Laparoscopic liver hanging maneuver through the retrohepatic tunnel on the right side of the inferior vena cava combined with a simple vascular occlusion technique for laparoscopic right hemihepatectomy. Surg Endosc 2017;32:2932-2938. [PMID: 29270802 PMCID: PMC5956091 DOI: 10.1007/s00464-017-6007-x] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/21/2017] [Accepted: 12/06/2017] [Indexed: 12/16/2022]

Abstract

Background

Laparoscopic hepatectomy has been performed in many hospitals, with the development of the laparoscopic operation technique. However, performing complex laparoscopic hepatectomy, such as right hemihepatectomy, is still a challenge. The aim of this study was to describe the application of a simple vascular occlusion technique and new liver hanging maneuver (LHM) in complex laparoscopic hepatectomy, which are both advocated by Chen Xiaoping for open hepatectomy.

Methods

The clinical data of 29 consecutive patients who underwent laparoscopic right hemihepatectomy (LRH) from October 2014 to October 2016 were retrospectively analyzed. During operation, the vascular occlusion technique without hilus dissection and LHM through the retrohepatic avascular tunnel on the right side of the inferior vena cava were used.

Result

All 29 operations were successfully performed laparoscopically, while adopting Chen’s methods. The study consisted of 23 patients with hepatocellular carcinoma, four patients with intrahepatic cholangiocarcinoma, and two patients with hepatic metastasis of colonic carcinoma. The tumor size was 12.4 ± 1.9 cm. The operation time of LRH was 190.3 ± 49.9 min. The intraoperative blood loss of LRH was 281.7 ± 117.8 mL; five patients required blood transfusion, and the amount of blood transfusion was 300.0 ± 89.4 mL. No case was converted to open surgery, and no death occurred. All resulted in R0 resections. The median free margin was 20.1 ± 10.8 mm. The time of postoperative oral diet intake was 2.10 ± 0.96 days. The complication rate was 17.2%. The average hospital stay after operation was 10.0 ± 2.9 days.

Conclusion

Complex hepatectomy is a bloodless procedure that can be performed under a laparoscope safely using Chen’s methods of vascular occlusion technique and LHM.

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Laparoscopy-Assisted versus Open Hepatectomy for Live Liver Donor: Systematic Review and Meta-Analysis. Can J Gastroenterol Hepatol 2017;2017:2956749. [PMID: 29238704 PMCID: PMC5697375 DOI: 10.1155/2017/2956749] [Citation(s) in RCA: 19] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/22/2017] [Revised: 09/03/2017] [Accepted: 10/04/2017] [Indexed: 02/07/2023] Open