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Zhang C, Hao W, Guo X, Zhang Y, Fu H, Zhang J. Evaluation of Clinical Symptoms of Unilateral S1 Nerve Injury Caused by Disc Herniation the via High Resolution MRI and DTI. J Pain Res 2025; 18:2105-2114. [PMID: 40264909 PMCID: PMC12013630 DOI: 10.2147/jpr.s507867] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/21/2024] [Accepted: 04/09/2025] [Indexed: 04/24/2025] Open
Abstract
Background The status of the herniated disc or nucleus pulposus and the extent of injury and clinical symptoms of the compressed S1 nerve fiber bundle were evaluated by high-resolution Magnetic resonance imaging (MRI) and Diffusion tensor imaging (DTI) techniques. Methods Forty-two clinically proven patients with unilateral S1 nerve root compression were selected as the case group (n=42), and 20 healthy volunteers were selected as the control group (n=20). The general data, MRI features and DTI parameters were compared between groups. The effective indicators of S1 neurologic fiber bundle damage were screened by univariate logistic regression analysis and receiver operating characteristic (ROC) curve, and multi-factor logistic regression models were constructed to analyze the diagnostic efficiency of each model. Results There were no significant differences in age, gender, height, weight, fractional anisotropy (FA) value and apparent diffusion coefficient (ADC) value on both sides of S1 nerve root between groups (P >0.05). The FA value and ADC value of the nerve root on the affected side of the patient were significantly different from those on the healthy side and those on the corresponding side of the control group (all P <0.05), and all of them were effective indicators of the damage of S1 nerve. The sensitivity, specificity and area under the curve of the damaged nerve fiber bundle were detected by multi-factor logistic regression models constructed with FA+rFA and FA+rFA+rADC of the affected nerve root, respectively 95.20%, 72.00%, 0.939, and 97.60%, 80.00%, 0.944. Conclusion High-resolution MRI and DTI can quantitatively evaluate the degree of nerve fiber bundle injury and clinical symptoms caused by lumbar disc herniation.
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Affiliation(s)
- ChaoYang Zhang
- Department of Radiology, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China
| | - Wei Hao
- Department of Radiology, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China
| | - Xiaobo Guo
- Department of Orthopaedics, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China
| | - Yuna Zhang
- Department of Radiology, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China
| | - Hao Fu
- Department of Radiology, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China
| | - Jiashan Zhang
- Department of Radiology, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China
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Li J, Song Y, Zhao Y, Su D, Li M, Zhao S. The impact of collaborative pain management by healthcare providers on sleep quality and self-efficacy in perioperative lumbar surgery patients. Sci Rep 2025; 15:5397. [PMID: 39948106 PMCID: PMC11825839 DOI: 10.1038/s41598-024-83927-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/03/2024] [Accepted: 12/18/2024] [Indexed: 02/16/2025] Open
Abstract
The present study aimed to investigate the effects of collaborative pain management by healthcare providers on sleep quality and self-efficacy in perioperative lumbar disc herniation patients. A total of 300 lumbar disc herniation patients admitted to our hospital from February 2022 to February 2023 were selected as the research subjects. They were divided into a study group (receiving collaborative pain management by healthcare providers) and a control group (receiving conventional pain management), with 150 patients in each group. Surgical parameters, pain levels at different time points, as well as pre- and post-intervention pain levels, sleep quality, self-efficacy, lumbar function, patients' satisfaction, and psychological status were compared between the two groups. There were no significant differences between the two groups in terms of gender, age, smoking, alcohol consumption, body mass index, disease duration, type and location of lumbar disc herniation, and comorbidities (P > 0.05). Surgical duration, blood loss, and time to first meal did not significantly differ between the two groups (P > 0.05). However, the study group had significantly shorter times to first ambulation, first gas passage, first bowel movement, and length of hospital stay compared to the control group (P < 0.05). Pre-intervention comparisons of pain levels showed no significant differences between the two groups (P > 0.05). Postoperatively, at 12, 24, 48, and 72 h, the study group had lower pain levels than the control group, with statistically significant differences (P < 0.05). Pre-intervention comparisons of daytime dysfunction, hypnotic drug use, sleep disturbances, sleep efficiency, sleep duration, time to fall asleep, and sleep quality revealed no significant differences between the two groups (P > 0.05). However, post-intervention, the study group exhibited significantly lower PSQI scores in daytime dysfunction, hypnotic drug use, sleep disturbances, sleep efficiency, sleep duration, time to fall asleep, and sleep quality compared to the control group (P < 0.05). Pre-intervention comparisons of pain management, physical function, and symptom coping showed no significant differences between the two groups (P > 0.05). After intervention, the study group demonstrated significantly better pain management, physical function, and symptom coping compared to the control group (P < 0.05). Before the intervention, subjective symptoms, bladder function, daily activity limitation, and clinical signs showed no significant differences between the two groups (P > 0.05). After the intervention, however, the study group exhibited significantly better subjective symptoms, bladder function, reduced daily activity limitation, and clinical signs compared to the control group (P < 0.05). Before the intervention, there were no significant difference in patients' satisfaction, anxiety score, and depression score between the two groups (P > 0.05). After the intervention, the study group showed lower anxiety score and depression score, and higher satisfaction with the nursing intervention compared to the control group (all P < 0.05). Collaborative pain management by healthcare providers can effectively improve sleep quality and enhance self-efficacy in perioperative lumbar surgery patients, and holds promise for clinical application.
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Affiliation(s)
- Jucai Li
- Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
| | - Yanli Song
- Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
| | - Yixin Zhao
- Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
| | - Dan Su
- Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
| | - Meina Li
- Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
| | - Shu'e Zhao
- Office of Academic Affairs, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang, 050051, Hebei, China.
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Costa F, Oertel J, Zileli M, Restelli F, Zygourakis CC, Sharif S. Role of surgery in primary lumbar disk herniation: WFNS spine committee recommendations. World Neurosurg X 2024; 22:100276. [PMID: 38496347 PMCID: PMC10943953 DOI: 10.1016/j.wnsx.2024.100276] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/28/2023] [Accepted: 02/01/2024] [Indexed: 03/19/2024] Open
Abstract
Objective To provide the most up-to-date recommendations on the role of surgery in first-time lumbar disk herniations (LDH) in order to standardize surgical management. Methods We performed a literature search in PubMed, Scopus, and Embase from 2012 to 2022 using the following keywords: "lumbar disk herniation AND surgery". Our initial search yielded 2610 results, which were narrowed down to 283 papers after standardized screening critera were applied. The data from these 283 papers were presented and discussed at two international meetings of the World Federation of Neurosurgical Societies (WFNS) Spine Committee, where the Delphi method was employed and ten spine experts voted on five final consensus statements. Results and Conclusions: The WFNS Spine Committee's guidelines cover four main topics: (1) role and timing of surgery in first-time LDH; (2) role of minimally invasive techniques in LDH; (3) extent of disk resection in LDH surgery; (4) role of lumbar fusion in the context of LDH. Surgery for LDH is recommended for failure of conservative treatment, cauda equina syndrome, and progressive neurological impairment, including severe motor deficits. In the latter cases, early surgery is associated with faster recovery and may improve patient outcomes. Minimally invasive techniques have short-term advantages over open procedures, but there is insufficient evidence to make a recommendation for or against the choice of a specific surgical procedure. Sequestrectomy and standard microdiscectomy demonstrated similar clinical results in terms of pain control, recurrence rate, functional outcome, and complications at short and medium-term follow-up. Lumbar fusion is not recommended as a routine treatment for first-time LDH, although it may be considered in specific patients affected by chronic axial pain or instability.
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Affiliation(s)
- Francesco Costa
- Spine Surgery Unit - Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
| | - Joachim Oertel
- Department of Neurosurgery, Saarland University Medical Center and Saarland University Faculty of Medicine, Homburg-Saar, Germany
| | - Mehmet Zileli
- Department of Neurosurgery, Ege University, Izmir, Turkey
- Department of Neurosurgery, Gaziantep, Turkey
| | - Francesco Restelli
- Spine Surgery Unit - Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
| | - Corinna Clio Zygourakis
- Department of Neurosurgery, Stanford University School of Medicine Palo Alto - CA (USA), USA
| | - Salman Sharif
- Department of Neurosurgery, Liaquat National Hospital and Medical College, Karachi, Pakistan
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Pojskic M, Bisson E, Oertel J, Takami T, Zygourakis C, Costa F. Lumbar disc herniation: Epidemiology, clinical and radiologic diagnosis WFNS spine committee recommendations. World Neurosurg X 2024; 22:100279. [PMID: 38440379 PMCID: PMC10911853 DOI: 10.1016/j.wnsx.2024.100279] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/28/2023] [Accepted: 02/01/2024] [Indexed: 03/06/2024] Open
Abstract
Objective To formulate the most current, evidence-based recommendations regarding the epidemiology, clinical diagnosis, and radiographic diagnosis of lumbar herniated disk (LDH). Methods A systematic literature search in PubMed, MEDLINE, and CENTRAL was performed from 2012 to 2022 using the search terms "herniated lumbar disc", "epidemiology", "prevention" "clinical diagnosis", and "radiological diagnosis". Screening criteria resulted in 17, 16, and 90 studies respectively that were analyzed regarding epidemiology, clinical diagnosis, and radiographic diagnosis of LDH. Using the Delphi method and two rounds of voting at two separate international meetings, ten members of the WFNS (World Federation of Neurosurgical Societies) Spine Committee generated eleven final consensus statements. Results The lifetime risk for symptomatic LDH is 1-3%; of these, 60-90% resolve spontaneously. Risk factors for LDH include genetic and environmental factors, strenuous activity, and smoking. LDH is more common in males and in 30-50 year olds. A set of clinical tests, including manual muscle testing, sensory testing, Lasegue sign, and crossed Lasegue sign are recommended to diagnose LDH. Magnetic resonance imaging (MRI) is the gold standard for confirming suspected LDH. Conclusions These eleven final consensus statements provide current, evidence-based guidelines on the epidemiology, clinical diagnosis, and radiographic diagnosis of LDH for practicing spine surgeons worldwide.
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Affiliation(s)
- Mirza Pojskic
- Department of Neurosurgery, University of Marburg, Germany
| | - Erica Bisson
- Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA
| | - Joachim Oertel
- Department of Neurosurgery, Saarland University Medical Centre, Homburg, Saarland, Germany
| | - Toshihiro Takami
- Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Japan
| | - Corinna Zygourakis
- Department of Neurosurgery, Stanford University Medical Center, Stanford, CA, USA
| | - Francesco Costa
- Spine Surgery Unit (NCH4) - Department of Neurosurgery - Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
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Cao G, Li Y, Wu S, Li W, Long J, Xie Y, Xia J. Clinical feasibility of MRI-based synthetic CT imaging in the diagnosis of lumbar disc herniation: a comparative study. Acta Radiol 2024; 65:41-48. [PMID: 37071506 PMCID: PMC10798008 DOI: 10.1177/02841851231169173] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/29/2022] [Accepted: 12/05/2022] [Indexed: 04/19/2023]
Abstract
BACKGROUND Computed tomography (CT) and magnetic resonance imaging (MRI) are indicated for use in preoperative planning and may complicate diagnosis and place a burden on patients with lumbar disc herniation. PURPOSE To investigate the diagnostic potential of MRI-based synthetic CT with conventional CT in the diagnosis of lumbar disc herniation. MATERIAL AND METHODS After obtaining prior institutional review board approval, 19 patients who underwent conventional and synthetic CT imaging were enrolled in this prospective study. Synthetic CT images were generated from the MRI data using U-net. The two sets of images were compared and analyzed qualitatively by two musculoskeletal radiologists. The images were rated on a 4-point scale to determine their subjective quality. The agreement between the conventional and synthetic images for a diagnosis of lumbar disc herniation was determined independently using the kappa statistic. The diagnostic performances of conventional and synthetic CT images were evaluated for sensitivity, specificity, and accuracy, and the consensual results based on T2-weighted imaging were employed as the reference standard. RESULTS The inter-reader and intra-reader agreement were almost moderate for all evaluated modalities (κ = 0.57-0.79 and 0.47-0.75, respectively). The sensitivity, specificity, and accuracy for detecting lumbar disc herniation were similar for synthetic and conventional CT images (synthetic vs. conventional, reader 1: sensitivity = 91% vs. 81%, specificity = 83% vs. 100%, accuracy = 87% vs. 91%; P < 0.001; reader 2: sensitivity = 84% vs. 81%, specificity = 85% vs. 98%, accuracy = 84% vs. 90%; P < 0.001). CONCLUSION Synthetic CT images can be used in the diagnostics of lumbar disc herniation.
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Affiliation(s)
- Gan Cao
- Department of Radiology, Longgang Central Hospital of Shenzhen, Shenzhen, PR China
- Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, Shenzhen, PR China
| | - Yafen Li
- School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, PR China
| | - Shibin Wu
- PingAn Technology, Shenzhen, Guangdong, PR China
| | - Wen Li
- Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, PR China
| | - Jia Long
- Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, Shenzhen, PR China
| | - Yaoqin Xie
- Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, PR China
| | - Jun Xia
- Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, Shenzhen, PR China
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Sun C, Sun K, Wang S, Wang Y, Yuan P, Li Z, Yang S, Zhang J, Jia Y, Wang W, Qi B, Yang B, Liu J, Wei X, Zhu L. Effect of Baimai ointment on lumbar disc herniation: A multicentre, prospective, randomised, double-blind, placebo-controlled trial. PHYTOMEDICINE : INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY 2024; 122:155138. [PMID: 37922792 DOI: 10.1016/j.phymed.2023.155138] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/10/2023] [Revised: 09/21/2023] [Accepted: 10/04/2023] [Indexed: 11/07/2023]
Abstract
BACKGROUND Baimai ointment is a traditional Tibetan topical ointment, which is widely used for various diseases related to the skeletal muscular system and neurological rehabilitation. It has demonstrated good clinical effectiveness. However, there is currently a lack of high-quality evidence regarding the clinical effectiveness of Baimai ointment in treating lumbar disc herniation (LDH). PURPOSE In this study, we conducted a prospective, multicenter, double-blind, randomized controlled trial at eight hospitals in China to investigate the clinical effectiveness of Baimai ointment in the treatment of LDH. METHODS Participants aged 18-65 years were diagnosed as LDH and were randomly assigned to receive either Baimai ointment or placebo. The treatment duration was 2 weeks, with 1-week follow-up after treatment. The primary outcome measures included VAS and JOA score. The secondary outcome measures included Likert scale, compliance with health education and the incidence of rescue therapy. The intervention effects on these outcomes were examined by generalized estimating equations (GEE) with baseline measurement as the covariates. All statistical analysis were performed using SPSS 25.0 and Python 3.11. RESULTS In total, 228 participants were screened from August 25, 2021 to January 31, 2022 at 8 Grade-A tertiary hospitals in China. Finally, 194 eligible participants were randomly assigned to the Baimai ointment group and placebo group in a 1:1 ratio. At the end of 2-week treatment (14th day) and 1-week follow-up after treatment (21st day), the decrease of VAS reached 39.57% (95% CI: 34.29, 44.86) and 36.85% (95% CI: 32.04, 41.66), the decrease in JOA score reached 27.74% (95% CI: 23.05, 32.43) and 26.25 % (95% CI: 20.82, 31.69) in Baimai ointment group. A significant group-by-time interaction indicated a difference for VAS between intervention over time (χ2 = 26.81, p = 0.020), but JOA score and Likert scale did not reach statistical significance. The adjusted net difference of VAS was statistically significant from 10th day of treatment (p < 0.05). After 2-week treatment, the relief rate of VAS was 30.85% (21.95, 41.34) in Baimai ointment group and 22.73% (14.75, 33.13) in placebo group (χ2 = 1.53, p = 0.217). It demonstrated Baimai ointment in improving VAS and JOA score was valuable from a clinical view by measuring MCID. Moreover, the Likert scale, the incidence of rescue therapy and compliance with health education did not reach statistical significance. There was no evidence showing that Baimai ointment could cause serious adverse reactions in treating patients with LDH. CONCLUSION Baimai ointment demonstrated significantly higher rates of symptom relief compared to the placebo for LDH patients, particularly in terms of relieving pain. Moreover, further high-quality randomized controlled trials were necessary to confirm these positive results. The study protocol is registered with the Clinical Trials Registry (registration number: ISRCTN11912818).
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Affiliation(s)
- Chuanrui Sun
- Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, China
| | - Kai Sun
- Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, China
| | - Shangquan Wang
- Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, China
| | - Yanguo Wang
- Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300250, China
| | - Puwei Yuan
- Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, China
| | - Zhenhua Li
- Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, 130012, China
| | - Shaofeng Yang
- The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China
| | - Jianhua Zhang
- The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230031, China
| | - Yusong Jia
- Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, 100700, China
| | - Wei Wang
- Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
| | - Baoyu Qi
- Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, China
| | - Bowen Yang
- Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, China
| | - Jianping Liu
- Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
| | - Xu Wei
- Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, China; Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.
| | - Liguo Zhu
- Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, China.
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Shen Y, Xu W, Huang L. Infrared laser angle instrument-assisted technique for lumbar disc puncture. Asian J Surg 2023; 46:5514-5515. [PMID: 37541895 DOI: 10.1016/j.asjsur.2023.07.130] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/06/2023] [Accepted: 07/24/2023] [Indexed: 08/06/2023] Open
Affiliation(s)
- Yongbo Shen
- Department of Pain, Haining People's Hospital, Haining, Zhejiang, 314400, PR China
| | - Wenyan Xu
- Department of Outpatient, Haining People's Hospital, Haining, Zhejiang, 314400, PR China
| | - Lianghui Huang
- Department of Pain, Haining People's Hospital, Haining, Zhejiang, 314400, PR China.
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Zhang W, Wang G, Xie R, Zhan J, Zhu L, Wan C, Xie H, Cai C, Du Y. Traditional Chinese exercises on pain and disability in middle-aged and elderly patients with lumbar disc herniation: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne) 2023; 10:1265040. [PMID: 38020108 PMCID: PMC10663407 DOI: 10.3389/fmed.2023.1265040] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/21/2023] [Accepted: 10/19/2023] [Indexed: 12/01/2023] Open
Abstract
Background Traditional Chinese exercises (TCEs) have played a significant role in treating various diseases. However, there is limited research assessing the efficacy of TCEs in treating Lumbar disc herniation (LDH). This study aimed to systematically evaluate the effects of four commonly used TCEs (Baduanjin, Yijinjing, Taichi, and Wuqinxi) on pain and disability in elderly patients with LDH. Objectives To assess the quality of relevant randomized controlled trials (RCTs) to provide evidence support for the treatment of LDH. Methods RCTs were identified through eight databases. Meta-analysis and trial sequence analysis (TSA) were conducted using RevMan 5.4, Stata 17.0, and TSA 0.9. Results A total of 22 RCTs, involving 1931 patients, were included in the analysis. TCEs exhibited a superior effectiveness in treating LDH compared to the control group. However, the TSA analysis suggested the possibility of false positives, indicating the need for more high-quality RCT evidence. Nevertheless, TCEs showed reliable results in significantly improving the VAS score and JOA score of LDH patients. Conclusion Current evidence indicates that the four TCEs have advantages in treating LDH in middle-aged and elderly individuals. However, considering the limitations of this study, we need to exercise caution in drawing conclusions, and further research is required to validate these findings. Systematic Review Registration http://www.crd.york.ac.uk/PROSPERO, identifier [CRD42023431633].
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Affiliation(s)
- Weiye Zhang
- Third Department of Sports Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
| | - Gewen Wang
- Third Department of Sports Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
| | - Rong Xie
- Third Department of Sports Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
| | - Jiawen Zhan
- Third Department of Sports Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
- Beijing Key Laboratory of Bone Setting Technology of Traditional Chinese Medicine, Beijing, China
| | - Liguo Zhu
- Third Department of Sports Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
- Beijing Key Laboratory of Bone Setting Technology of Traditional Chinese Medicine, Beijing, China
- Second Department of Spine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
| | - Chunyou Wan
- Department of Orthopedics, Tianjin Hospital, Tianjin, China
| | - Hualong Xie
- Third Department of Sports Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
| | - Chuhao Cai
- Third Department of Sports Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
| | - Yuxuan Du
- Third Department of Sports Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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Zhang S, Zhang Y, Huang L, Zhang S, Lu C, Liu Z, Kang C, Wang Z. Oblique lateral interbody fusion with internal fixations in the treatment for cross-segment degenerative lumbar spine disease (L2-3 and L4-5) finite element analysis. Sci Rep 2023; 13:17116. [PMID: 37816744 PMCID: PMC10564781 DOI: 10.1038/s41598-023-43399-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/04/2022] [Accepted: 09/22/2023] [Indexed: 10/12/2023] Open
Abstract
Multi-segmental lumbar degenerative disease, including intersegmental disc degeneration, is found in clinical practice. Controversy still exists regarding the treatment for cross-segment degeneration. Oblique Lateral Interbody Fusion (OLIF) with several internal fixations was used to treat cross-segment lumbar degenerative disease. A whole lumbar spine model was extracted from CT images of the whole lumbar spine of patients with lumbar degeneration. The L2-3 and L4-5 intervertebral spaces were fused with OLIF using modeling software, the Pedicle screws were performed on L2-3 and L4-5, and different internal fixations were performed on L3-4 in Finite Element (FE) software. Among the six 10 Nm moments of different directions, the L3-4 no surgery (NS) group had the relatively largest Range of Motion (ROM) in the whole lumbar spine, while the L2-5 Long segmental fixation (LSF)group had the smallest ROM and the other groups had similar ROM. The ROM in the L1-2 and L5-S1 was relatively close in the six group models, and the articular cartilage stress and disc stress on the L1-2 and L5-S1 were relatively close. In contrast, the L3-4 ROM differed relatively greatly, with the LSF ROM the smallest and the NS ROM the largest, and the L3-4 Coflex (Coflex) group more active than the L3-4 Bacfuse (Bacfuse) group and the L3-4 translaminar facet screw fixation (TFSF) group. The stress on the articular cartilage and disc at L3-4 was relatively greater in the NS disc and articular cartilage, and greater in the Coflex group than in the Bacfuse and TFSF groups, with the greatest stress on the internal fixation in the TFSF group, followed by the Coflex group, and relatively similar stress in the Bacfuse, LSF, and NS groups. In the TFSF group, the stress on the internal fixation was greater than the yield strength among different directional moments of 10 Nm, which means it is unsuitable to be an internal fixation. The LSF group had the greatest overall ROM, which may lead to postoperative low back discomfort. The NS group has the greatest overall ROM, but its increased stress on the L3-4 disc and articular cartilage may lead to accelerated degeneration of the L3-4 disc and articular cartilage. The Coflex and Bacfuse groups had a reduced L3-4 ROM but a greater stress on disc compared to the LSF group, which may lead to disc degeneration in the long term. However, their stress on the articular cartilage was relatively low. Coflex and Bacfuse can still be considered better surgical options.
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Affiliation(s)
- Shuyi Zhang
- Department of Orthopedics, Fuzhou Second Hospital, Fuzhou, 350007, Fujian, China
- Department of Spine Surgery, Affiliated Hospital of Chengde Medical College, Chengde, 067000, Hebei, China
| | - Yilong Zhang
- Department of Spine Surgery, Affiliated Hospital of Chengde Medical College, Chengde, 067000, Hebei, China
| | - Licai Huang
- Department of Orthopedics, Fuzhou Second Hospital, Fuzhou, 350007, Fujian, China
| | - Shuao Zhang
- School of Civil Engineering, Lanzhou University of Technology, Lanzhou, 730000, Gansu, China
| | - Chenshui Lu
- Department of Foreign Languages, Fu Zhou University, Fuzhou, 350100, Fujian, China
| | - Zhengpeng Liu
- Department of Spine Surgery, Affiliated Hospital of Chengde Medical College, Chengde, 067000, Hebei, China
| | - Chan Kang
- Department of Orthopedics, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea
| | - Zhao Wang
- Department of Orthopedics, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea.
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Zhang X, Yang K, Wang S, Tang B, Yin H, Lei Q, Zhou G, Gu M, Shi M, Zhao C, Li S, Li Z. Efficacy and safety of Yaobitong capsule for acute lumbar disc herniation: A protocol for a multi-center randomized controlled trial. Medicine (Baltimore) 2022; 101:e31533. [PMID: 36451389 PMCID: PMC9704913 DOI: 10.1097/md.0000000000031533] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/04/2022] Open
Abstract
BACKGROUND There are few effective conservative therapies for acute lumbar disc herniation (LDH), and the choice of nonsteroidal anti-inflammatory drugs is not recommended for all patients. The purpose of this study was to compare the effect of Yaobitong capsule with celecoxib capsule, and to further confirm the safety and efficacy of Yaobitong capsule. METHODS This study is a large sample multicenter randomized controlled trial. Eight hospitals served as sub centers to recruit patients. A total of 258 patients are divided into Yaobitong group and celecoxib group according to the ratio of 1:1. Celecoxib or Yaobitong capsule was taken orally for 14 days. Patients will complete the trial after 3 months of follow-up, and independent statisticians who are blinded to random assignment will analyze the data using SAS 9.3 software. The primary outcome was the visual analogue scale (VAS) score after 14 days of treatment, and Japanese Orthopaedic Association (JOA), Oswestry Disability Index (ODI), and SF-12 will be regarded as secondary outcomes. Safety indexes will be recorded before and after treatment, and adverse events (AEs) will be recorded throughout this trial. DISCUSSION This study will evaluate the efficacy and safety of Yaobitong capsule in treating LDH. The experimental results will provide evidence support to treat LDH with Yaobitong capsule.
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Affiliation(s)
- Xianshuai Zhang
- Changchun University of Chinese Medicine, Changchun City, China
| | - Kexin Yang
- China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China
| | - Siyi Wang
- Changchun University of Chinese Medicine, Changchun City, China
| | - Bin Tang
- China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China
| | - He Yin
- China Academy of Chinese Medical Sciences, Wangjing Hospital, Beijing, China
| | - Qunhui Lei
- Changchun University of Chinese Medicine, Changchun City, China
| | - Guohui Zhou
- Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, China
| | - Mingyu Gu
- Changchun University of Chinese Medicine, Changchun City, China
| | - Mingpeng Shi
- Changchun University of Chinese Medicine, Changchun City, China
| | - Changwei Zhao
- Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, China
| | - Shaojun Li
- Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, China
| | - Zhenhua Li
- Affiliated Hospital of Changchun University of Chinese Medicine, Changchun City, Jilin Province, China
- * Correspondence: Zhenhua Li, Affiliated Hospital of Changchun University of Chinese medicine, No. 1478 Gongnong Road, Chaoyang District, Changchun City, Jilin Province, China (e-mail: )
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Zhao J, Zhang P, Gao G. Study on Intelligent Traditional Chinese Medicine Fumigation for Treating Lumbar Intervertebral Disc Herniation Based on Medical Big Data Mining. CONTRAST MEDIA & MOLECULAR IMAGING 2022; 2022:4658192. [PMID: 36313963 PMCID: PMC9584737 DOI: 10.1155/2022/4658192] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 08/25/2022] [Revised: 09/15/2022] [Accepted: 09/23/2022] [Indexed: 01/26/2023]
Abstract
With the improvement of the traditional Chinese medicine fumigation (TCMF), more and more people are studying lumbar intervertebral disc herniation (LIDH) by TCMF. In order to clarify the thermodynamic mechanism of TCMF to LIDH and provide a model reference for individualized diagnosis, the lower control system is compiled by the microprocessor, and the upper control system is compiled by computer technology of VB. In this new system, the medical information of patients is recorded in the databases by the upper control system, and clinical diagnosis and treatment experience are packaged in the lower control system. The simulation results and clinical examples show that the new control system of TCMF has better clinical efficacy for LIDH patients, which not only effectively improves the pain symptoms of LIDH patients but is also economical and safe.
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Affiliation(s)
- Jirong Zhao
- Department of Spinal Surgery, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, China
- Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, China
| | - Ping Zhang
- College of Electrical and Information Engineering, Lanzhou University of Technology, Lanzhou, Gansu 730050, China
| | - Guodong Gao
- Department of Spinal Surgery, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, China
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12
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Ji Y, Zhang Q, Song Y, Hu Q, Fekete G, Baker JS, Gu Y. Biomechanical characteristics of 2 different posterior fixation methods of bilateral pedicle screws: A finite element analysis. Medicine (Baltimore) 2022; 101:e30419. [PMID: 36086784 PMCID: PMC10980486 DOI: 10.1097/md.0000000000030419] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/16/2022] [Accepted: 07/27/2022] [Indexed: 12/13/2022] Open
Abstract
BACKGROUND To explore the biomechanical characteristics of 2 posterior bilateral pedicle screw fixation methods using finite element analysis. METHODS A normal L3-5 finite element model was established. Based on the verification of its effectiveness, 2 different posterior internal fixation methods were simulated: bilateral pedicle screws (model A) were placed in the L3 and L5 vertebral bodies, and bilateral pedicle screws (model B) were placed in the L3, L4, and L5 vertebral bodies. The stability and stress differences of intervertebral discs, endplates, screws, and rods between models were compared. RESULTS Compared with the normal model, the maximum stress of the range of motion, intervertebral disc, and endplate of the 2 models decreased significantly. Under the 6 working conditions, the 2 internal fixation methods have similar effects on the stress of the endplate and intervertebral disc, but the maximum stress of the screws and rods of model B is smaller than that of model A. CONCLUSIONS Based on these results, it was found that bilateral pedicle screw fixation in 2 vertebrae L3 and L5 can achieve similar stability as bilateral pedicle screw fixation in 3 vertebrae L3, L4, and L5. However, the maximum stress of the screw and rod in model B is less than that in model A, so this internal fixation method can effectively reduce the risk of fracture. The 3-dimensional finite element model established in this study is in line with the biomechanical characteristics of the spine and can be used for further studies on spinal column biomechanics. This information can serve as a reference for clinicians for surgical selection.
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Affiliation(s)
- Yulei Ji
- Faculty of Sports Science, Ningbo University, Ningbo, China
| | - Qiaolin Zhang
- Faculty of Sports Science, Ningbo University, Ningbo, China
| | - Yang Song
- Faculty of Sports Science, Ningbo University, Ningbo, China
- Doctoral School on Safety and Security Sciences, Óbuda University, Budapest, Hungary
| | - Qiuli Hu
- Faculty of Sports Science, Ningbo University, Ningbo, China
| | - Gusztáv Fekete
- Savaria Institute of Technology, Eötvös Loránd University, Szombathely, Hungary
| | - Julien S. Baker
- Department of Sport and Physical Education, Hong Kong Baptist University, Hong Kong, China
| | - Yaodong Gu
- Faculty of Sports Science, Ningbo University, Ningbo, China
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Comparison of Needle-Warming Moxibustion and Other Physical Therapies for Lumbar Disc Herniation: A Meta-analysis. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE 2022; 2022:2986223. [PMID: 35936359 PMCID: PMC9352493 DOI: 10.1155/2022/2986223] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 06/17/2022] [Revised: 07/13/2022] [Accepted: 07/16/2022] [Indexed: 11/18/2022]
Abstract
Background. Needle-warming moxibustion (NWM) demonstrates a controversial effect on lumbar disc herniation (LDH). This study is aimed at comparing the efficacy of NWM and conventional acupuncture or other physical therapies on LDH through a meta-analysis. Methods. Potentially eligible literatures were retrieved and screened from electronic databases. The subject of the literature was a comparison of NWM and conventional acupuncture or other physical therapies for LDH. The methodological quality was evaluated by the Jadad scale. The chi-square test was used for the heterogeneity test. Subgroup analysis was used to explore the source of heterogeneity. Risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI) was used to describe the effect size. The publication bias was evaluated by Egger’s test. Results. The effective rate of NWM in the treatment of LDH was significantly higher than that of conventional acupuncture (
) and lumbar traction (
) There was no significant difference in the effective rate between NWM and electric acupuncture for LDH (
). VAS of LDH patients treated with NWM was lower than conventional acupuncture (
) and lumbar traction (
) but statistically insignificant with electric acupuncture (
). JOA scores of LDH patients treated with NWM were higher than those with conventional acupuncture (
) and lumbar traction (
) but statistically insignificant with electric acupuncture (
). The long-term effective rate of NWM on LDH was higher than that of conventional acupuncture (
). In this study, no heterogeneity (
) and publication bias (
) among the literature were noted. Conclusion. The effect of NWM on LDH was superior to traction therapy and conventional acupuncture therapy, but similar to electric acupuncture for LDH. High-quality randomized controlled trials were still needed to confirm the results.
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Wang XZ, Xue KY, Chen PN, Xiao CH, Cui J, Fu J. Ma’s bamboo-based medicinal moxibustion therapy of low back pain in lumbar disc herniation: study protocol for a randomized controlled trial. Trials 2022; 23:446. [PMID: 35643520 PMCID: PMC9145155 DOI: 10.1186/s13063-022-06382-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/26/2021] [Accepted: 05/04/2022] [Indexed: 11/28/2022] Open
Abstract
Background Lumbar disc herniation (LDH) is a common and frequently occurring disease in clinics. Low back pain and sciatica are the presenting symptoms of LDH. To some extent, it can be considered that measures with the capability to improve low back pain or sciatica have the potential to treat LDH. Ma’s bamboo-based medicinal moxibustion therapy can effectively reduce the degree of low back pain and has been widely used. Studies of small sample size have seen significant improvement on pain relief. The aim of this trial is to evaluate the clinical efficacy and safety of Ma’s bamboo-based medicinal moxibustion therapy in the treatment of LDH low back pain. Methods/design The trial is a multicenter, randomized, parallel-group, non-inferiority study. Three hundred and twelve patients will be randomly assigned to a Ma’s bamboo-based medicinal moxibustion group (n=156) and an acupuncture group (n=156). Patients in each group will receive treatment every day, 6 times a week, 12 times in total. Follow-up will be conducted 14 days after treatment. The primary outcome will be the visual analog scale(VAS) at baseline, after 6 times of treatment, end of treatment, and follow-up. The secondary outcomes will include Oswestry disability indexes (ODI), modified Japanese Orthopaedic Association low back pain (M-JOA) score, serum β-endorphin (β-EP), and serum substance P (SP). β-EP and SP, as well as safety evaluation indexes (routine blood, liver, and kidney function and electrocardiogram), will be measure at baseline and after the end of treatment. The number, nature, and severity of adverse events will be recorded. Discussion The results of the trial will compare the efficacy of low back pain in LDH between Ma’s bamboo-based medicinal moxibustion group and the acupuncture group and will be expected to make a systematic and objective evaluation of the clinical efficacy and safety of Ma’s bamboo-based medicinal moxibustion therapy. Trial registration ChiCTR2000038725. Registered on 29 September 2020. Supplementary Information The online version contains supplementary material available at 10.1186/s13063-022-06382-x.
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15
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Tarcău E, Ianc D, Sirbu E, Ciobanu D, Boca IC, Marcu F. Effects of Complex Rehabilitation Program on Reducing Pain and Disability in Patients with Lumbar Disc Protrusion—Is Early Intervention the Best Recommendation? J Pers Med 2022; 12:jpm12050741. [PMID: 35629163 PMCID: PMC9144614 DOI: 10.3390/jpm12050741] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/08/2022] [Revised: 04/13/2022] [Accepted: 04/29/2022] [Indexed: 11/30/2022] Open
Abstract
(1) Background: Due to its frequency and possible complications, low back pain (LBP) has a high social impact, it is a common problem of the active population and the second reason for visiting a physician. In patients with lumbar disc protrusion (LDP), one of the most common causes of LBP, the nucleus pulposus bulges against the disc and then protrudes into the spinal cord, but the annulus fibrosus remains intact; (2) Objectives: The primary objective of this study was to determine the efficacy of a rehabilitation treatment (RT) comprising electrotherapy (ET), hydrotherapy (HT) and individualized physical therapy (PT) versus ET alone in patients with LDP. The second objective was to investigate whether there is a correlation between early RT and the symptomatology of patients with LDP; (3) Methods: The research was conducted between July 2021 and January 2022 at the Ceres Hotel Treatment Centre from Baile 1 Mai, Romania, and all the study subjects signed an informed consent form. For this study, the block randomization method was used to randomize subjects into groups that resulted in equal sample size, in order to maintain a reasonably good balance among groups. Therefore, the two groups had the same number of subjects (30 subjects) and the randomization was made taking into account the patient’s motivation or the subject’s willingness to receive not only electrotherapy treatment, but also the physical exercises and hydrotherapy. The eligibility criteria were: low back pain for more than three months, an MRI confirmed diagnosis of LDP (without dural compression), and ability to perform a PT program. The control group received only a classical ET program. In addition, the patients in the experimental group received a complex individualized PT program associated with HT and ET. To achieve these objectives, the study subjects were monitored for spinal mobility (lateral lumbar flexion—LLF, index fingers-ground—IFG, lumbar Schober tests for flexion—LS, Inverted Schober test for extension—ILS), trunk flexor and extensor muscle strength (LF strength, LE strength), level of pain (Short Form McGill Pain Questionnaire—SF-MPQ, Visual Analogue Scale—VAS), and the degree of limitation in activities of daily living (Oswestry Disability Index—ODI); (4) Results: Comparing the evolution of the subjects, using the One-Way ANOVA between groups, we observed a significant improvement in all variables [SF-MPQ (95% CI, 7.996/11.671), VAS (95% CI, 1.965/3.169), mobility FTF (95% CI, −7.687/−3.940), LS (95% CI, 2.272/2.963), LE strength (95% CI, −5.676/−3.324), LF strength (95% CI, −5.970/−3.630), disability (95% CI, 8.026/10.441) after six months of treatment for the experimental group subjects. A clear correlation was found, using the Bravis–Pearson test, between the earliest possible initiation of RT and improvement of patients’ symptoms; (5) Conclusion: The current study proves the importance of combining ET with HT and PT. The earlier the RT is implemented, the lower the pain perception and level of disability associated with the lumbar disease.
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Affiliation(s)
- Emilian Tarcău
- Department of Physical Education, Sport and Physiotherapy, University of Oradea, 410087 Oradea, Romania; (E.T.); (D.I.); (D.C.); (I.C.B.)
- Human Performance Research Center, University of Oradea, 410087 Oradea, Romania
| | - Dorina Ianc
- Department of Physical Education, Sport and Physiotherapy, University of Oradea, 410087 Oradea, Romania; (E.T.); (D.I.); (D.C.); (I.C.B.)
- Human Performance Research Center, University of Oradea, 410087 Oradea, Romania
| | - Elena Sirbu
- Department of Physical Therapy and Special Motricity, Faculty of Physical Education and Sport, West University of Timisoara, 300223 Timisoara, Romania
- Correspondence:
| | - Doriana Ciobanu
- Department of Physical Education, Sport and Physiotherapy, University of Oradea, 410087 Oradea, Romania; (E.T.); (D.I.); (D.C.); (I.C.B.)
- Human Performance Research Center, University of Oradea, 410087 Oradea, Romania
| | - Ioan Cosmin Boca
- Department of Physical Education, Sport and Physiotherapy, University of Oradea, 410087 Oradea, Romania; (E.T.); (D.I.); (D.C.); (I.C.B.)
- Human Performance Research Center, University of Oradea, 410087 Oradea, Romania
| | - Florin Marcu
- Department of Psychoneuroscience and Rehabilitation, University of Oradea, 410087 Oradea, Romania;
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Peng G, Zheng Y, Luo D. Effects of Acupuncture and Moxibustion Combined with Needle-Knife on Pain and Lumbar Function in Patients with Lumbar Disc Herniation. JOURNAL OF HEALTHCARE ENGINEERING 2022; 2022:9185384. [PMID: 35432832 PMCID: PMC9010147 DOI: 10.1155/2022/9185384] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 02/04/2022] [Revised: 03/09/2022] [Accepted: 03/12/2022] [Indexed: 11/18/2022]
Abstract
This study aimed for the analysis of the effect of acupuncture and moxibustion combined with needle-knife on pain and lumbar function in patients with lumbar disc herniation. From June 2019 to February 2021, the medical records of 126 patients with lumbar disc herniation admitted to the department of orthopedics of our hospital were selected and divided into the control group (n = 63) treated with acupuncture and moxibustion and the observation group (n = 63) treated with acupuncture and moxibustion combined with needle-knife according to different treatment regimens. After 4 weeks of treatment, the clinical efficacy, pain status, and lumbar function were compared between the two groups. The concentrations of relevant inflammatory factors (IL-6, IL-10, TNF-α, and MMP-2) in peripheral blood of the two patients before and after treatment were measured by enzyme-linked immunosorbent assay (ELISA). After treatment, the overall response rate was 93.65% in the observation group, which was higher than 80.95% in the control group (P < 0.05); the visual blurred score (VAS) scores of lower limbs and waist in the observation group were lower than those in the control group, while the expression of pain mediators serotonin (5-HT) and prostaglandin E2 (PEG2) was also lower than that in the control group (P < 0.05); the Oswestry disability index (ODI) in the observation group was lower than that in the control group, while the Japanese Orthopedic Association assessment treatment score (JOA) was higher than that in the control group (P < 0.05). After treatment, the concentration levels in peripheral blood (IL-6, IL-10, TNF-α, and MMP-2) were significantly lower in the observation group than in the control group (P < 0.05). Acupuncture and moxibustion combined with needle-knife is effective in the treatment of lumbar disc herniation, which helps to improve the clinical efficacy, relieve pain symptoms, promote the improvement of lumbar function, and contribute to the reduction of inflammatory factors.
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Affiliation(s)
- Guoqiang Peng
- Orthopedics Department of Traditional Chinese Medicine, Taizhou Jiangyan Hospital of Traditional Chinese Medicine, Taizhou, China
| | - Yanfang Zheng
- Comprehensive Nursing Clinic, PLA Rocket Force Characteristic Medical Center, Beijing, China
| | - Dejun Luo
- Department of Orthopedics, the People's Hospital of Jianyang City, Jianyang, China
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Yue L, Sun MS, Chen H, Mu GZ, Sun HL. Extracorporeal Shockwave Therapy for Treating Chronic Low Back Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials. BIOMED RESEARCH INTERNATIONAL 2021; 2021:5937250. [PMID: 34840977 PMCID: PMC8617566 DOI: 10.1155/2021/5937250] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 07/15/2021] [Accepted: 10/19/2021] [Indexed: 12/28/2022]
Abstract
OBJECTIVE To assess the effectiveness and safety of extracorporeal shockwave therapy (ESWT) for the treatment of chronic low back pain (CLBP). METHODS This was a systematic review and meta-analysis of randomized controlled trials (RCTs) designed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement standard. We identified relevant studies by searching multiple electronic databases, trial registries, and websites up to April 30, 2021, and examining reference lists. We selected RCTs that compared ESWT, in unimodal or multimodal therapeutic approaches, with sham ESWT or other active therapies. Two investigators independently extracted data and assessed the risk of bias and quality of the evidence. The main outcomes were pain intensity and disability status, examined as standardized mean differences (SMD) with 95% confidence intervals (CI). The risk of bias was assessed by using Cochrane Back and Neck (CBN) Group risk of bias tool and Jadad score, and GRADE was applied to determine the confidence in effect estimates. Heterogeneity was explored using sensitivity analysis and meta-regression. RESULTS Ten RCTs, including a total of 455 young to middle-aged individuals (29.2-55.8 years), were identified. Compared with control, the ESWT group showed lower pain intensity at month 1 (SMD = -0.81, 95% CI -1.21 to -0.42), as well as lower disability score at month 1 (SMD = -1.45, 95% CI -2.68 to -0.22) and at month 3 (SMD = -0.69, 95% CI -1.08 to -0.31). No serious shockwave-related adverse events were reported. CONCLUSION The use of ESWT in CLBP patients results in significant and quantifiable reductions in pain and disability in the short term. However, further well-conducted RCTs are necessary for building high-quality evidence and promoting the application of ESWT in clinical practice.
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Affiliation(s)
- Lei Yue
- Department of Orthopaedics, Peking University First Hospital, Beijing 100034, China
| | - Ming-shuai Sun
- Department of General Surgery, Peking University First Hospital, Beijing 100034, China
| | - Hao Chen
- Department of Rehabilitation, Peking University First Hospital, Beijing 100034, China
| | - Guan-zhang Mu
- Department of Orthopaedics, Peking University First Hospital, Beijing 100034, China
| | - Hao-lin Sun
- Department of Orthopaedics, Peking University First Hospital, Beijing 100034, China
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Peng BG, Liu YQ, Ma K. Editorial for the special issue of the Chinese Association for the Study of Pain. World J Clin Cases 2021; 9:2022-2026. [PMID: 33850921 PMCID: PMC8017508 DOI: 10.12998/wjcc.v9.i9.2022] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/30/2020] [Revised: 02/19/2021] [Accepted: 03/18/2021] [Indexed: 02/06/2023] Open
Abstract
The Ministry of Health of China officially issued a document, adding the first level diagnosis and treatment discipline "Algology" in the list of diagnosis and treatment subjects of medical institutions on July 16, 2007. As the most important pain academic organization in China, the Chinese Association for the Study of Pain has made outstanding contributions in promoting the development of pain discipline and in establishing pain standards and disease diagnosis and treatment guidelines. In this special issue, under the leadership of Yan-Qing Liu, Chairman of the 7th Committee of the Chinese Association for the Study of Pain, nine consensus and one guideline were included.
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Affiliation(s)
- Bao-Gan Peng
- Department of Orthopedics, The Third Medical Center, General Hospital of the Chinese People’s Liberation Army, Beijing 100039, China
| | - Yan-Qing Liu
- Department of Algology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
| | - Ke Ma
- Department of Algology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
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