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Men MÖ, Akpınar R, Çomunoğlu C, Özşahin MK, Çomunoğlu N. Histopathological, Immunohistochemical and Clinical Features of Granular Cell Tumors: Re-Evaluation of Malignancy Criteria in a Series of 54 Tumors. Int J Surg Pathol 2025:10668969251326253. [PMID: 40095553 DOI: 10.1177/10668969251326253] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/19/2025]
Abstract
Aim. Granular cell tumors (GCTs) are mostly benign. Malignant GCTs are extremely rare. Although the criteria proposed by Fanburg-Smith et al are widely used, some authors do not find them especially useful. We aimed to present our GCT case series consisting of 54 patients from 2 institutions during a 22-year period and evaluate these tumors according to these criteria of malignancy. Materials and Methods. Fifty-four patients with GCT diagnosed between 2000 and 2024 were retrospectively reviewed. All hematoxylin/eosin-stained slides were evaluated for spindling pattern, nucleolar prominence, pleomorphism, geographical necrosis, increase in nuclear/cytoplasmic ratio, and mitotic index. Results. Overall, 7 tumors were classified as "Malignant GCT." Histopathologically all malignant tumors showed nucleolar prominence and pleomorphism. Ki-67 proliferation index was 3% or higher in 6 tumors. In 4 of the malignant GCTs, lymph node metastasis was present at the time of diagnosis. In 2 of these patients, lung metastasis and in 1 patient liver metastasis were also found. Another malignant tumor showed bone invasion. In one of the malignant tumors, local recurrence, lymph node metastasis, and lung metastasis occurred 1 year after excision. Conclusions. Malignant GCTs had behaved as frequently metastasizing high-grade sarcomas.
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Affiliation(s)
- Mine Önenerk Men
- Department of Pathology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey
| | - Reha Akpınar
- Department of Pathology, Tatvan Government Hospital, Bitlis, Turkey
| | - Cem Çomunoğlu
- Department of Pathology, Prof. Dr Cemil Taşçıoğlu Ş. Hospital, Istanbul, Turkey
| | - Mahmut Kürşat Özşahin
- Department of Orthopaedic Surgery, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey
| | - Nil Çomunoğlu
- Department of Pathology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey
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Peng Y, Lv ML, Zhong JQ, Feng H. Atypical granular cell tumor of right calf muscle: Report of a case. Asian J Surg 2024:S1015-9584(24)02383-2. [PMID: 39505639 DOI: 10.1016/j.asjsur.2024.10.072] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/21/2024] [Revised: 10/12/2024] [Accepted: 10/18/2024] [Indexed: 11/08/2024] Open
Affiliation(s)
- Yu Peng
- Department of Radiology, Zigong First People's Hospital, 643000, Zigong, PR China.
| | - Min-Li Lv
- Department of Radiology, Zigong First People's Hospital, 643000, Zigong, PR China
| | - Jian-Quan Zhong
- Department of Radiology, Zigong First People's Hospital, 643000, Zigong, PR China
| | - Hao Feng
- Department of Radiology, Zigong First People's Hospital, 643000, Zigong, PR China
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Yan J. Granular cell tumor of the breast: A case report and review of literature. World J Clin Cases 2023; 11:8044-8049. [DOI: 10.12998/wjcc.v11.i33.8044] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/21/2023] [Revised: 09/26/2023] [Accepted: 11/13/2023] [Indexed: 11/24/2023] Open
Abstract
BACKGROUND Granular cell tumor (GCT) of the breast (GCTB) is a rare neoplasm that can exhibit malignant characteristics both clinically and radiologically. This tumor can also coexist and colocalize with breast carcinoma.
CASE SUMMARY We present a patient with this uncommon tumor and discuss the diagnostic and therapeutic approaches in order to further the knowledge of GCTB and prevent misdiagnosis and overtreatment. The characteristics of the tumor, methods of diagnosis, therapy and postoperative pathological outcomes were analyzed, and relevant literatures of GCTs were reviewed. The patient underwent surgery after core needle biopsy, and the excised neoplasm was sent for pathological examination. Histological analysis revealed nests of cells with abundant pink granular cytoplasm, confirming the diagnosis of GCTB.
CONCLUSION As manifestations of GCT and malignancy can mimic each other, a careful histological examination is essential before major surgery. Treatment consisting of complete excision with close clinical follow-up is recommended.
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Affiliation(s)
- Jun Yan
- Department of Breast Surgery, The University of Hong Kong - Shenzhen Hospital, Shenzhen 518000, Guangdong Province, China
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Kneitz H, Frings V, Kircher S, Goebeler M. Expression of Connexin 43 in Granular Cell Tumors of the Skin, Tongue and Esophagus. Dermatopathology (Basel) 2023; 10:184-192. [PMID: 37366801 DOI: 10.3390/dermatopathology10020026] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/18/2023] [Revised: 06/13/2023] [Accepted: 06/14/2023] [Indexed: 06/28/2023] Open
Abstract
BACKGROUND Granular cell tumors (GCT) are rare neoplasms of Schwann cell origin occurring in the skin and in other organs. The etiopathogenesis of GCT is yet poorly understood. Connexin 43 (Cx43) is the most broadly expressed gap junction protein in humans, the tumoral role of which has been investigated in several types of tumors. Its role in GCT of the skin, oral cavity and gastrointestinal tract is as yet unknown. METHODS Herein, we present a study on the immunohistochemical expression of Cx43 in GCT of the skin (n = 15), tongue (n = 4) and esophagus (n = 3). Immunolabeling was scored positive (weak (+), moderate (++) or strong (+++)). RESULTS Cx43 was expressed by all cases of GCT of the skin, tongue and esophagus (22/22), showing moderate to strong staining. All tissue sections of GCT were characterized by a diffuse, cytoplasmic staining pattern of the tumor cells. None of those showed membranous or nuclear staining. CONCLUSION Our results suggest that Cx43 probably plays an important role in the development of this rare tumor entity.
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Affiliation(s)
- Hermann Kneitz
- Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany
| | - Verena Frings
- Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany
| | - Stefan Kircher
- Department of Pathology, University Hospital Würzburg, 97080 Würzburg, Germany
| | - Matthias Goebeler
- Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany
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Raveendran C, Elias R, Parameswaran S, Yadev IP. Recurrent primary cutaneous granular cell tumor of the neck in an Asian women: A case report. Int J Surg Case Rep 2023; 106:108213. [PMID: 37080152 DOI: 10.1016/j.ijscr.2023.108213] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/26/2023] [Revised: 04/11/2023] [Accepted: 04/11/2023] [Indexed: 04/22/2023] Open
Abstract
INTRODUCTION AND IMPORTANCE Granular cell tumors are uncommon neoplasms. They appear in the skin, subcutaneous tissues, and many internal organs. It is essential to diagnose this disease because it mimics other tumors clinically. We report this case because of the rarity of tumors in Asians and the necessity of excision with clear margins. CASE PRESENTATION A 55-year-old Indian woman reported swelling in the right side of the neck for six months and gradually increasing in size. Two years ago, she had a similar swelling excised from her neck. She had wide local excision of the tumor with wider margins in the plastic surgery department, and histopathology revealed a granular cell tumor with clear margins. She is undergoing close follow-up with history and physical examination with no evidence of disease recurrence. CLINICAL DISCUSSION Granular cell tumors can have recurrences. These slow-growing tumors appear benign. Histopathological examination with careful assessment of high-risk features is vital in evaluating Granular cell tumors. Wide local excision with clear margins is the mainstay of treatment. CONCLUSION Achieving clear margins in the head and neck area is sometimes tricky for granular cell tumors. Margin positivity is associated with a high risk of local recurrence and needs re-excision of the tumor for adequate local control.
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Affiliation(s)
- Ciniraj Raveendran
- Department of Radiation Oncology, Medical College Thiruvananthapuram, Kerala State, 695011, India.
| | - Ruby Elias
- Department of Pathology, Medical College Thiruvananthapuram, Kerala State, 695011, India
| | - Sabu Parameswaran
- Department of Plastic Surgery, Medical College Thiruvananthapuram, Kerala State, 695011, India
| | - I P Yadev
- Department of General Surgery, Medical College Thiruvananthapuram, Kerala State, 695011, India
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Amphlett A. An Update on Cutaneous Granular Cell tumours for Dermatologists and Dermatopathologists. Clin Exp Dermatol 2022; 47:1916-1922. [PMID: 35727729 DOI: 10.1111/ced.15309] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 06/20/2022] [Indexed: 11/29/2022]
Abstract
Granular cell tumours are rare soft tissue neoplasms which occur at a wide variety of sites and commonly involve the skin. Distinction between benign and malignant granular cell tumours is important because benign tumours are commonly cured by complete excision and malignant tumours commonly recur and cause fatal metastatic disease. Communication between the dermatologist and pathologist is also important, as the pathologist may provide false reassurance by evaluating a benign appearing part of a clinically malignant tumour. The following review summarises the current literature on the epidemiology, clinical presentation, pathology, radiology, treatment and prognosis of cutaneous granular cell tumours, with a focus on improving diagnosis and management for dermatologists and dermatopathologists.
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Wei MZ, Yan ZJ, Jiang JH, Jia XL. Atypical granular cell tumor of the urinary bladder: A case report. World J Clin Cases 2021; 9:8453-8460. [PMID: 34754853 PMCID: PMC8554444 DOI: 10.12998/wjcc.v9.i28.8453] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/19/2021] [Revised: 05/14/2021] [Accepted: 07/07/2021] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Granular cell tumor (GCT) is a neurogenic tumor mainly occurring in the head and neck. GCT in the genitourinary system is extremely rare and only sporadic cases of urinary bladder GCT have been reported. Most urinary bladder GCT cases are benign and only two malignant cases have been reported. Due to its rarity, no consensus criteria for the treatment of urinary bladder GCT are available at present.
CASE SUMMARY A 62-year-old Chinese woman was found to have a urinary bladder tumor without any clinical manifestations on physical examination. Cystoscopy revealed a semispherical shaped lesion measuring approximately 4.0 cm in diameter at the junction of the left wall and roof of the bladder, which was covered with normal bladder mucosa. Computed tomography scan demonstrated a high-density lesion on the left wall of the bladder, measuring approximately 2.9 cm × 2.4 cm with clear boundaries. Contrast-enhanced pelvic magnetic resonance imaging revealed a space-occupying lesion on the left wall of the bladder (non-mucosal origin/ external pressure), which was preliminarily suspected to be a desmoplastic fibroma or leiomyoma. In the context of the above findings, a pre-operative diagnosis of bladder leiomyoma was made. The patient consequently underwent a laparoscopic partial cystectomy. The resected bladder mass looked yellowish and well-demarcated, measuring 4.0 cm × 3.5 cm and infiltrated the muscular layer. The diagnosis of urinary bladder GCT was finally made by postoperative pathology, with positive immunohistochemical S-100 staining and negative pancytokeratin. The patient has been followed for 6 mo so far, with no tumor recurrence detected.
CONCLUSION This case highlights the biological feature and differential diagnosis of urinary bladder GCT at the pathological and molecular levels. Transurethral resection of the bladder tumor and partial cystectomy are recommended in most urinary bladder GCT cases, while radical cystectomy is recommended in malignant cases.
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Affiliation(s)
- Ming-Ze Wei
- Department of Urology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315000, Zhejiang Province, China
| | - Ze-Jun Yan
- Department of Urology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315000, Zhejiang Province, China
| | - Jun-Hui Jiang
- Department of Urology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315000, Zhejiang Province, China
| | - Xiao-Long Jia
- Department of Urology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315000, Zhejiang Province, China
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Kavak ZN, Gökaslan H, Küllü S. Vulvar granular cell tumor (ABRIKOSSOFF TUMOR); a tumor of vulva which is rare but needs care. Gynecol Oncol Rep 2021; 36:100767. [PMID: 33997222 PMCID: PMC8102154 DOI: 10.1016/j.gore.2021.100767] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/09/2021] [Revised: 04/04/2021] [Accepted: 04/14/2021] [Indexed: 11/18/2022] Open
Abstract
•Abrikossoff tumor is a rare tumor but not always benign.•Re-excission for positive margins in benign tumors may not be invariably necessary.•Cosmetic issues may play role in the treatment and follow-up in benign tumors.
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Affiliation(s)
| | - Hüsnü Gökaslan
- Obstetric and Gynecology, Academic Hospital, İstanbul, Turkey
- Corresponding author at: Ob &Gyn, Academic Hospital, Nuhkuyusu caddesi No: 95, Bağlarbaşı, Üsküdar, İstanbul, Turkey.
| | - Sevgi Küllü
- Pathology, Academic Hospital, İstanbul, Turkey
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Bagchi S, Kundu S, Chatterjee A, Chatterjee RP. Atypical Presentation of Granular Cell Tumor Involving Tongue: A Rare Case Report. Int J Appl Basic Med Res 2021; 11:111-113. [PMID: 33912433 PMCID: PMC8061612 DOI: 10.4103/ijabmr.ijabmr_438_19] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/30/2019] [Revised: 12/02/2020] [Accepted: 01/31/2021] [Indexed: 11/04/2022] Open
Abstract
Granular cell tumor (GCT) is a rare benign tumor chiefly affecting the orofacial region, especially tongue. The origin of this neoplasia, after remaining a controversy for years, was finally identified to be from Schwann cell or neuroendocrine cell. They usually present as asymptomatic, firm, sessile, submucosal, solitary, or multiple nodule/papule like lesions. Histopathologically, the presence of sheets, cords or nests of large cells having abundant, eosinophilic granular cytoplasm, and pseudoepitheliomatous hyperplasia are the characteristic features of this neoplasm. Immunohistochemical stains such as S100, Cluster of differentiation 68, neuron-specific enolase, and laminin also aid in the proper diagnosis of granular cells. We hereby present a case of GCT in a 50-year-old male, which had a unique exophytic appearance, probably being only the second to be reported till date.
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Affiliation(s)
- Sudeshna Bagchi
- Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India
| | - Sanchita Kundu
- Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India
| | - Arunit Chatterjee
- Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India
| | - Rudra Prasad Chatterjee
- Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India
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A Rare Intramuscular Tumor in Gracilis Muscle: Granular Cell Tumor. Indian J Surg Oncol 2020; 11:215-218. [PMID: 33364702 DOI: 10.1007/s13193-020-01172-w] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/30/2020] [Accepted: 07/07/2020] [Indexed: 10/23/2022] Open
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Brunsgaard EK, Wallis L, Cody B, Cavanaugh K. Atypical granular cell tumor developing within a tattoo. JAAD Case Rep 2020; 6:546-548. [PMID: 32490122 PMCID: PMC7260400 DOI: 10.1016/j.jdcr.2020.04.030] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022] Open
Affiliation(s)
| | - Luke Wallis
- Rush University Medical Center, Chicago, Illinois
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Mobarki M, Dumollard JM, Dal Col P, Camy F, Peoc'h M, Karpathiou G. Granular cell tumor a study of 42 cases and systemic review of the literature. Pathol Res Pract 2020; 216:152865. [PMID: 32089415 DOI: 10.1016/j.prp.2020.152865] [Citation(s) in RCA: 55] [Impact Index Per Article: 11.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/05/2019] [Revised: 01/30/2020] [Accepted: 02/10/2020] [Indexed: 02/07/2023]
Abstract
BACKGROUND Granular cell tumor (GCT) remains a diagnostic clinicopathologic problem because the exact frequency of its detailed morphological and clinical characteristics is unknown as most observations are collected from small series or isolated cases. Herein, our aim is to highlight the frequency of all clinicopathological characteristics of this rare tumor based in our series and the available medical (PubMed) literature. MATERIAL AND METHODS 42 cases were evaluated for: tissue layers involved by the tumor (in skin and mucosae), growth pattern, nuclear pleomorphism, mitotic index, necrosis, spindling, calcification, hyalinization, and pustule-ovoid bodies of Milian, as well as perineural and vascular invasion, and the presence of adjacent epithelium changes, and lymphocytes and eosinophils infiltration., Follow-up was analyzed. The tumors were subclassified into benign, atypical and malignant according to Fanburg-Smith criteria and into benign or GCT of uncertain malignant potential according to Nasser criteria. The same characteristics were analyzed for 1499 cases reviewed according to PRISMA guidelines. RESULTS In the current series, the mean age at diagnosis was 45.8 years (range 6-69 years). Most patients were females (60 %) and the involved organs were by descending frequency: skin and subcutaneous tissue, bronchus, esophagus, breast, tongue, larynx, pharynx, gingiva, trachea, right colon, vulva, and hypopharynx. No recurrence or progression was seen, despite 32 cases were incompletely excised, with the exception of one malignant tumor. The growth pattern was either infiltrative (85.71 %) or well limited (7.14 %). Sixteen tumors had vesicular nuclei. Mitotic activity was found in two tumors. Lymphocytic infiltration was found in 14 tumors. Eosinophils were present in 6 cases. One GCT of the right colon showed extensive calcification and hyalinization. Perineural invasion was noted in 6 lesions. No vascular invasion was found. One tumor was clinically malignant and the patient died 2 years after diagnosis. Medical literature review showed similar results in terms of frequency of the reported clinical and morphological features. Among cases with available follow up, almost 20 % showed positive margins and of those 20 % developed local recurrence. According to the Fanburg-Smith criteria, 72 % would be benign, 17 % atypical and 11 % malignant tumors, while according to those of Nasser, 93 % would be benign and 7% of uncertain malignant potential. However, true malignancy, as affirmed by metastasis of GCT is found in almost 2.5 % of the cases. CONCLUSION GCT is a usually benign tumor, affecting any anatomic location. Necrosis and mitotic activity seem to be the most effective histologic criteria for detecting aggressive tumors, but the presence of metastasis (2.5 % of the cases) remains the most accepted definitive criterion for diagnosis of malignant GCT.
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Affiliation(s)
- Mousa Mobarki
- Department of Pathology, North Hospital, University Hospital of St-Etienne, France; Department of Pathology, Facutly of Medicine, Jazan University, Jazan, Saudi Arabia.
| | - Jean Marc Dumollard
- Department of Pathology, North Hospital, University Hospital of St-Etienne, France
| | - Pierre Dal Col
- Department of Pathology, North Hospital, University Hospital of St-Etienne, France
| | - Florian Camy
- Department of Pathology, North Hospital, University Hospital of St-Etienne, France
| | - Michel Peoc'h
- Department of Pathology, North Hospital, University Hospital of St-Etienne, France
| | - Georgia Karpathiou
- Department of Pathology, North Hospital, University Hospital of St-Etienne, France
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Meani F, Di Lascio S, Wandschneider W, Montagna G, Vitale V, Zehbe S, Harder Y, Parvex SL, Spina P, Canonica C, Generali D, Pagani O. Granular cell tumor of the breast: a multidisciplinary challenge. Crit Rev Oncol Hematol 2019; 144:102828. [PMID: 31710955 DOI: 10.1016/j.critrevonc.2019.102828] [Citation(s) in RCA: 13] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/05/2018] [Revised: 06/12/2019] [Accepted: 10/25/2019] [Indexed: 01/12/2023] Open
Abstract
Granular cell tumors are rare soft tissue tumors; they are almost never malignant, but can mimic a carcinoma clinically, radiologically and microscopically. The finding of a suspicious lump often entails subsequent diagnostic procedures that can pose significant anxiety on patients before reaching a challenging differential diagnosis. The physical and psychological burden is even more significant when such findings occur during the follow up of a previous oncologic condition. Sometimes the fear for a potential local or distant recurrence can be responsible for a misdiagnosis and lead to patient overtreatment.
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Affiliation(s)
- Francesco Meani
- Centro di Senologia della Svizzera Italiana (CSSI), Deparment of Obstetrics and Gynecology, Ente Ospedaliero Cantonale (EOC), Ospedale Italiano di Lugano, Via Pietro Capelli 1, 6962, Viganello, Ticino, Switzerland.
| | - Simona Di Lascio
- Centro di Senologia della Svizzera Italiana (CSSI), Deparment of Medical Oncology, Istituto Oncologico della Svizzera Italiana (IOSI), Ospedale Italiano di Lugano, Via Pietro Capelli 1, 6962, Viganello, Ticino, Switzerland
| | - Wiebke Wandschneider
- Centro di Senologia della Svizzera Italiana (CSSI), Deparment of Obstetrics and Gynecology, Ente Ospedaliero Cantonale (EOC), Ospedale Italiano di Lugano, Via Pietro Capelli 1, 6962, Viganello, Ticino, Switzerland
| | - Giacomo Montagna
- Centro di Senologia della Svizzera Italiana (CSSI), Deparment of Obstetrics and Gynecology, Ente Ospedaliero Cantonale (EOC), Ospedale Italiano di Lugano, Via Pietro Capelli 1, 6962, Viganello, Ticino, Switzerland
| | - Valerio Vitale
- Centro di Senologia della Svizzera Italiana (CSSI), Deparment of Radiology, Ente Ospedaliero Cantonale (EOC), Ospedale Italiano di Lugano, Via Pietro Capelli 1, 6962, Viganello, Ticino, Switzerland
| | - Sabine Zehbe
- Centro di Senologia della Svizzera Italiana (CSSI), Deparment of Radiology, Ente Ospedaliero Cantonale (EOC), Ospedale San Giovanni, via Ospedale 12, 6500, Bellinona, Switzerland
| | - Yves Harder
- Centro di Senologia della Svizzera Italiana (CSSI), Deparment of Reconstuctive and Plastic Surgery, Ente Ospedaliero Cantonale (EOC), Ospedale Italiano di Lugano, Via Pietro Capelli 1, 6962, Viganello, Ticino, Switzerland
| | - Sandra Leoni Parvex
- Centro di Senologia della Svizzera Italiana (CSSI), Istituto di Patologia Cantonale, via Selva 24, 6600, Locarno, Ticino, Switzerland
| | - Paolo Spina
- Centro di Senologia della Svizzera Italiana (CSSI), Istituto di Patologia Cantonale, via Selva 24, 6600, Locarno, Ticino, Switzerland
| | - Claudia Canonica
- Centro di Senologia della Svizzera Italiana (CSSI), Deparment of Obstetrics and Gynecology, Ente Ospedaliero Cantonale (EOC), Ospedale Italiano di Lugano, Via Pietro Capelli 1, 6962, Viganello, Ticino, Switzerland
| | - Daniele Generali
- Department of Medical Surgery and Health Sciences, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy
| | - Olivia Pagani
- Centro di Senologia della Svizzera Italiana (CSSI), Deparment of Medical Oncology, Istituto Oncologico della Svizzera Italiana (IOSI), Ospedale Italiano di Lugano, Via Pietro Capelli 1, 6962, Viganello, Ticino, Switzerland; Geneva University Hospitals, Geneva, Switzerland
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Liu Y, Zheng Q, Wang C, Wang J, Ming J, Zhang Y, Li X, Cho WCS, Wang L, Li QC, Qiu XS, Wang EH. Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break-apart FISH in 45 cases. Oncol Lett 2019; 18:6355-6360. [PMID: 31788112 PMCID: PMC6865705 DOI: 10.3892/ol.2019.10995] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/07/2018] [Accepted: 08/01/2019] [Indexed: 12/15/2022] Open
Abstract
Transcription factor E3 (TFE3) is a useful marker for tumors with Xp11.2 translocation, including alveolar soft part sarcoma and renal cell carcinoma. Recently, TFE3 overexpression was also found in granular cell tumors (GrCTs). However, the case cohorts of these two studies were limited to only 11 and 6 cases. Whether aberrant TFE3 expression is a common feature of Asian patients with GrCT requires further investigation. In the present study, immunohistochemical staining and TFE3 break-apart fluorescence in situ hybridization (FISH) assay were performed in 45 samples of GrCTs obtained from Chinese patients recruited from three medical centers in northeast China. Diffusive and marked nuclear staining for TFE3 was identified in 11/45 (24%) cases, which was lower than previously reported. Focal or weak TFE3 staining was identified in 13/45 (29%) cases. The remaining 21 cases were negative stained. In addition, GrCTs in subcutaneous tissue exhibited a relatively higher ratio (8/45, 18%) for TFE3 expression, compared with those in other sites. Furthermore, according to FISH data, no rearrangement or amplification of TFE3 was identified in these cases, whether they were positively or negatively stained for TFE3. The results from the present study demonstrated that part of patients GrCTs exhibited TFE3 overexpression, which suggested that this may not be derived from gene rearrangement.
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Affiliation(s)
- Yang Liu
- Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China
| | - Qin Zheng
- Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China
| | - Chen Wang
- Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China
| | - Jinping Wang
- Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China
| | - Jian Ming
- Department of Pathology, The 202nd Hospital of Chinese PLA, Shenyang, Liaoning 110003, P.R. China
| | - Yong Zhang
- Department of Pathology, Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China
| | - Xiaoman Li
- Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning 110001, P.R. China
| | - William Chi-Shing Cho
- Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, P.R. China
| | - Liang Wang
- Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China
| | - Qing-Chang Li
- Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China
| | - Xue-Shan Qiu
- Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China
| | - En-Hua Wang
- Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China
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Granular Cell Tumor over the Mons Pubis: An Uncommon Tumor. Case Rep Obstet Gynecol 2019; 2019:1279137. [PMID: 31223510 PMCID: PMC6541988 DOI: 10.1155/2019/1279137] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/02/2018] [Accepted: 05/06/2019] [Indexed: 11/18/2022] Open
Abstract
Granular cell tumors are uncommon, usually benign, soft tissue neoplasms of neural origin. They occur throughout the body; vulval involvement is uncommon and labium majus is the commonest site in vulva. Complete surgical excision is the preferred treatment of choice to prevent recurrence. Here, we present a benign granular cell tumor over the mons pubis of vulva in a 27-year-old woman.
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16
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Tosa M, Ansai SI, Ogawa R. Two Cases of Granular Cell Tumors that Clinically Mimicked Hypertrophic Scars and Keloids. J NIPPON MED SCH 2018; 85:279-282. [DOI: 10.1272/jnms.jnms.2018_85-44] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/19/2022]
Affiliation(s)
- Mamiko Tosa
- Department of Plastic, Reconstructive & Aesthetic Surgery, Nippon Medical School
| | - Shin-ichi Ansai
- Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital
| | - Rei Ogawa
- Department of Plastic, Reconstructive & Aesthetic Surgery, Nippon Medical School
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17
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Moten AS, Movva S, von Mehren M, Wu H, Esnaola NF, Reddy SS, Farma JM. Granular cell tumor experience at a comprehensive cancer center. J Surg Res 2018; 226:1-7. [DOI: 10.1016/j.jss.2018.01.027] [Citation(s) in RCA: 18] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/22/2017] [Revised: 12/10/2017] [Accepted: 01/17/2018] [Indexed: 12/20/2022]
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18
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Epidemiology of malignant cutaneous granular cell tumors: A US population-based cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) database. J Am Acad Dermatol 2017; 78:490-497.e1. [PMID: 28989104 DOI: 10.1016/j.jaad.2017.09.062] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/28/2017] [Revised: 09/19/2017] [Accepted: 09/24/2017] [Indexed: 12/16/2022]
Abstract
BACKGROUND Malignant cutaneous granular cell tumors (mcGCTs) are rare and associated with substantial morbidity and mortality. The literature includes single-institution studies. OBJECTIVE To examine the incidence, secondary malignancies, treatment, overall survival, and disease-specific survival (DSS) of patients with mcGCT. METHODS A population-based cohort analysis was conducted in the Surveillance, Epidemiology, and End Results database from 1973 to 2013 for patients with a diagnosis of mcGCT. Risk-adjusted associations between overall survival/DSS and patient characteristics and treatment modalities were assessed by Cox proportional hazard regression. Quantile regression was used to determine median survival times. RESULTS The 5-year DSS rate was 62.8%. Patients demonstrated an increased risk for renal and pancreatic cancers. In risk-adjusted models, male sex (hazard ratio [HR], 0.21; 95% confidence interval [CI], 0.06-0.82; P = .02), advanced cancer stage (HR, 2.29; 95% CI, 1.40-3.72; P < .01), and surgical resection (HR, 0.06; 95% CI, 0.01-0.59; P = .02) predicted DSS. Median survival time in years increased for males (1.39), earlier stage (0.60), and surgical intervention (5.34). LIMITATIONS Absent or incorrect reporting in retrospective Surveillance, Epidemiology, and End Results data is possible. The database is more likely to include academic centers. Some subanalyses may be underpowered because of the limited sample size for a rare cancer. CONCLUSIONS Our study presents an in-depth assessment of factors that identify high-risk patients. Residency in a nonmetro area, black race, female sex, and no surgical resection were each associated with poorer DSS.
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Mosea A, Alwahab Y, Coghlan K. Granular cell tumour developing in the background of a previous mandibular giant cell lesion: Case report. Int J Surg Case Rep 2016; 28:48-51. [PMID: 27689516 PMCID: PMC5043390 DOI: 10.1016/j.ijscr.2016.09.031] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/23/2016] [Revised: 09/20/2016] [Accepted: 09/20/2016] [Indexed: 11/27/2022] Open
Abstract
INTRODUCTION Granular cell tumours of the mandible are very rare. We present a unique case which has developed at the site of a previous giant cell lesion. PRESENTATION 51 year old Caucasian lady had excision of a recurrent giant cell lesion of the anterior mandible. Follow up showed evidence of radiographic recurrence. However, further biopsies from the same site showed granular cell tumour with soft tissues extension. The patient remains well on long term follow up with no evidence of recurrence. DISCUSSION This case is unique because the granular cell tumour has evolved from the site of a recurrent giant cell lesion. Conservative surgical excision was an adequate treatment option. CONCLUSION Within the limitations of our case study, a correlation between granular cell tumour and giant cell lesion is possible. However, more research is needed to prove this.
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Affiliation(s)
- Akeel Mosea
- The Princess Alexandra Hospital, Harlow, United Kingdom.
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20
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Gündüz Ö, Erkin G, Bilezikçi B, Adanalı G. Slowly Growing Nodule on the Trunk: Cutaneous Granular Cell Tumor. Dermatopathology (Basel) 2016; 3:23-7. [PMID: 27504442 PMCID: PMC4965530 DOI: 10.1159/000445479] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/20/2022] Open
Abstract
Granular cell tumor (GCT) is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. The tumor mostly presents with a symptomatic slowly growing solitary nodule and overlying normal skin; therefore, it is not always considered in the differential diagnosis. Here, we report a 58-year-old female patient who presented with a 4-year history of a slowly growing mass, with a dimension of 5 × 4 cm on her left waist, diagnosed as a GCT at the histopathological examination. The neoplastic cells had centrally located nuclei and granular eosinophilic cytoplasm and stained positively for S100, neuron-specific enolase, and CD68 antibodies. Fifteen months after surgery, the patient still showed no signs of local recurrence or metastases. Although a large diameter is a feature of malignant GCT, our case with cutaneous GCT was localized on the trunk and did not present malignant features clinically and histopathologically.
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Affiliation(s)
- Özge Gündüz
- Department of Dermatology, Ufuk University Faculty of Medicine, Ankara, Turkey
| | - Gül Erkin
- Departments of Dermatology, Guven Hospital, Ankara, Turkey
| | - Banu Bilezikçi
- Departments of Pathology, Guven Hospital, Ankara, Turkey
| | - Gökhan Adanalı
- Departments of Plastic Surgery, Guven Hospital, Ankara, Turkey
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21
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Imanishi J, Yazawa Y, Saito T, Shimizu M, Kawashima H, Ae K, Matsumine A, Torigoe T, Sugiura H, Joyama S. Atypical and malignant granular cell tumors in Japan: a Japanese Musculoskeletal Oncology Group (JMOG) study. Int J Clin Oncol 2016; 21:808-816. [DOI: 10.1007/s10147-016-0949-1] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/20/2015] [Accepted: 01/04/2016] [Indexed: 12/11/2022]
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22
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Porta N, Mazzitelli R, Cacciotti J, Cirenza M, Labate A, Lo Schiavo MG, Laghi A, Petrozza V, Della Rocca C. A case report of a rare intramuscular granular cell tumor. Diagn Pathol 2015; 10:162. [PMID: 26377191 PMCID: PMC4573292 DOI: 10.1186/s13000-015-0390-1] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/08/2015] [Accepted: 08/28/2015] [Indexed: 12/17/2022] Open
Abstract
Background Granular cell tumors (GCTs) were firstly described by Weber in 1854 and 70 years later by Abrikossoff and classified as benign tumors. Originally considered muscle tumors, they have been identified as neural lesions, due to their close association with nerve and to their immunohystochemical characteristics. GCTs are uncommon tumors and they may arise in any part of the body; they have been mainly observed in tongue, chest wall and upper extremities; less frequent sites are larynx, gastrointestinal tract, breast, pituitary stalk and the female anogenital region. Here we report a case of GCT showing an uncommon localization such as the upper third of the right rectus muscle of the abdominal wall. Case presentation A 45 year-old woman of Caucasian origin presented to the surgeon with a 6-month history of light pain in the upper third of the abdominal wall. Radiological exams (Ultrasonography, Computed Tomography and Contrast magnetic resonance imaging) showed a localized in the right rectus abdominis muscle. After excision, histological and immunohystochemical analysis, with the support of electron microscopy, allowed making diagnosis of granular cell tumor. Discussion After fist description by Abrikosoff in 1926 of GCT like mesenchymal tumor of unknown origin, in recent years immunohystochemical techniques definitely demonstrated the histogenetic derivation of GCT from Schwann cells. Granular cell tumors are rare, small, slow-growing, solitary and painless subcutaneous nodules which behave in a benign fashion, but can have a tendency to recur; in rare cases they can metastasize, when they became malignant; there are some clinical and histological criteria to suspect the malignance of this tumor. Conclusion It is important that clinicians, radiologists and pathologists are aware of the clinical presentation and histopathology of GCT for appropriate management, counselling and follow-up. In our case we had a complete radiological, morphological and immunohystochemical characterization of the lesion and a definitive diagnosis of benignity confirmed by electron microscopy.
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Affiliation(s)
- Natale Porta
- Department of Medico-Surgical Sciences and Biotechnologies, Histology Unit, Sapienza University of Rome, ICOT Hospital, Latina, Italy.
| | | | - Jessica Cacciotti
- Department of Medico-Surgical Sciences and Biotechnologies, Histology Unit, Sapienza University of Rome, ICOT Hospital, Latina, Italy.
| | - Mirko Cirenza
- Department of Medico-Surgical Sciences and Biotechnologies, Histology Unit, Sapienza University of Rome, ICOT Hospital, Latina, Italy.
| | - Agata Labate
- Pathology Unit, Casa di Cura "Cappellani Giomi", Messina, Italy.
| | | | - Andrea Laghi
- Department of Radiological, Oncological and Pathological Sciences, Radiology Unit, Sapienza University of Rome, ICOT Hospital, Latina, Italy.
| | - Vincenzo Petrozza
- Department of Medico-Surgical Sciences and Biotechnologies, Histology Unit, Sapienza University of Rome, ICOT Hospital, Latina, Italy.
| | - Carlo Della Rocca
- Department of Medico-Surgical Sciences and Biotechnologies, Histology Unit, Sapienza University of Rome, ICOT Hospital, Latina, Italy.
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23
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Liu TT, Han Y, Zheng S, Li B, Liu YQ, Chen YX, Liu YF, Wang EH. Primary cutaneous malignant granular cell tumor: a case report in China and review of the literature. Diagn Pathol 2015; 10:113. [PMID: 26187381 PMCID: PMC4506611 DOI: 10.1186/s13000-015-0357-2] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/30/2015] [Accepted: 07/09/2015] [Indexed: 12/15/2022] Open
Abstract
Granular cell tumor is rare and accounts for approximately 0.5 % of all soft tissue tumors. The malignant granular cell tumor, especially cutaneous malignant granular cell tumor is extremely rare. The present case is the first patient of primary cutaneous malignant granular cell tumor reported from China in English. A review of the literature is performed, and the presentation, position, pathological diagnosis, treatment and prognosis of the patients with cutaneous malignant granular cell tumor of the reported cases before is analysed.
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Affiliation(s)
- Ting-ting Liu
- Department of General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China.
| | - Yang Han
- Department of Pathology, First Affiliated Hospital of China Medical University, Shenyang, China.
| | - Song Zheng
- Department of Dermatology & STD, First Affiliated Hospital of China Medical University, Shenyang, China.
| | - Bo Li
- Department of Dermatology & STD, First Affiliated Hospital of China Medical University, Shenyang, China.
| | - Yu-qi Liu
- Graduate School of China Medical University, Shenyang, China.
| | - Yi-xian Chen
- Graduate School of China Medical University, Shenyang, China.
| | - Yong-feng Liu
- Department of General Surgery, First Affiliated Hospital of China Medical University, Shenyang, China.
| | - En-hua Wang
- Department of Pathology, First Affiliated Hospital of China Medical University, Shenyang, China.
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24
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Andalib A, Heidary M, Sajadieh-Khajouei S. Granular cell tumor presenting as a large leg mass. THE ARCHIVES OF BONE AND JOINT SURGERY 2014; 2:260-267. [PMID: 25692157 PMCID: PMC4328086] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Subscribe] [Scholar Register] [Received: 06/30/2014] [Accepted: 09/01/2014] [Indexed: 06/04/2023]
Abstract
Granular cell tumor is a rare benign neoplasm most commonly appears in the head and neck region, especially in the tongue, cheek mucosa, and palate. Occurrence in limbs is even rarer. These tumors account for approximately 0.5% of all soft tissue tumors. Granular cell tumor can also affect other organs including skin, breast, and lungs. Local recurrence and metastasis is potentially higher in malignant forms with poor prognosis in respect to the benign counterparts. The average diameter of the tumor is usually about 2-3 cm. We report a granular cell tumor in the leg with an unusual size.
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Affiliation(s)
- Ali Andalib
- Ali Andalib MD, Mohsen Heidary MD, Department of Orthopedic Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
| | - Mohsen Heidary
- Ali Andalib MD, Mohsen Heidary MD, Department of Orthopedic Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
| | - Sahar Sajadieh-Khajouei
- Ali Andalib MD, Mohsen Heidary MD, Department of Orthopedic Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
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25
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Toi PC, Siddaraju N, Basu D. Fine-needle aspiration cytology of granular cell tumor: A report of two cases. J Cytol 2013; 30:195-7. [PMID: 24130413 PMCID: PMC3793358 DOI: 10.4103/0970-9371.117641] [Citation(s) in RCA: 9] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/15/2022] Open
Abstract
Granular cell tumors (GCTs) are uncommon soft tissue tumors, which are difficult to diagnose merely on clinical examination. Being an effective first-line investigation, the fine-needle aspiration cytology (FNAC) plays a significant role in its pre-operative recognition. However, as the tumor is likely to mimic certain other lesions, a cytopathologist needs to be aware of its characteristic cytomorphology. We report two cases of GCT who presented with subcutaneous swellings in the left lower back and the right-sided anterior abdominal wall for 6 and 2 months, respectively. Both the patients had a clinical diagnosis of lipoma/neurofibroma. FNAC was done in both. In the first case a cytodiagnosis of xanthogranuloma was suggested and GCT in the second. Subsequent histologic examination of both showed features of GCT. FNAC would aid in presumptive diagnosis of GCT.
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Affiliation(s)
- Pampa Ch Toi
- Department of Pathology, JIPMER, Pondicherry, India
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26
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Hong SC, Lim YK, Chew SH, Chia YN, Yam KL. Case report of granular cell tumor of the vulva and review of current literature. GYNECOLOGIC ONCOLOGY CASE REPORTS 2012; 3:20-2. [PMID: 24371657 DOI: 10.1016/j.gynor.2012.10.008] [Citation(s) in RCA: 12] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/17/2012] [Accepted: 10/30/2012] [Indexed: 12/11/2022]
Abstract
► We present four cases of benign granular cell tumours of the vulva managed between 1998 and 2001. ► We discuss the clinical and histopathological features of this condition. ► Treatment of this condition is primarily surgical.
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Affiliation(s)
- S C Hong
- Department of General Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore
| | - Y K Lim
- Department of Gynaecological Oncology, KK Women's and Children's Hospital, Singapore
| | - S H Chew
- Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore
| | - Y N Chia
- Department of Gynaecological Oncology, KK Women's and Children's Hospital, Singapore
| | - K L Yam
- Department of Gynaecological Oncology, KK Women's and Children's Hospital, Singapore
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27
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Kim YI, Lee CK, Cho KH, Kim SH. Granular cell tumor of brachial plexus mimicking nerve sheath tumor: a case report. KOREAN JOURNAL OF SPINE 2012; 9:275-7. [PMID: 25983831 PMCID: PMC4431018 DOI: 10.14245/kjs.2012.9.3.275] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 07/19/2012] [Revised: 09/20/2012] [Accepted: 09/25/2012] [Indexed: 12/21/2022]
Abstract
Primary tumors of the brachial plexus region are rare and granular cell tumors arising from the brachial plexus region is an extremely rare disease. We present a case of granular cell tumor arising from of the brachial plexus which appeared to be a usual presentation of nerve sheath tumor before the pathological confirmation. We report a granular cell tumor of the brachial plexus with literature review. Total resection is important for good clinical outcome and prognosis in the treatment of granular cell tumor.
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Affiliation(s)
- Young-Im Kim
- Department of Neurosurgery, Ajou University School of Medicine, Suwon, Korea
| | - Chul-Kyu Lee
- Department of Neurosurgery, Ajou University School of Medicine, Suwon, Korea
| | - Ki Hong Cho
- Department of Neurosurgery, Ajou University School of Medicine, Suwon, Korea
| | - Sang-Hyun Kim
- Department of Neurosurgery, Ajou University School of Medicine, Suwon, Korea
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28
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Abike F, Bingol B, Temizkan O, Dunder I, Kilic GS, Cetin G, Gundogdu C. Primary tracheal adenocystic carcinoma and tracheal tumors during pregnancy. Rare Tumors 2011; 3:e33. [PMID: 22066040 PMCID: PMC3208420 DOI: 10.4081/rt.2011.e33] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/10/2011] [Revised: 08/02/2011] [Accepted: 08/02/2011] [Indexed: 12/28/2022] Open
Abstract
Cancer complicates approximately 0.1% of all pregnancies. Primary tracheal carcinoma is one of very rarely seen tumors and the rate of its being seen makes up approximately % 0.2 of all tumors of respiratory tract. The patient, 28 years old, who has 28-weeks-pregnant, was diagnosed with primary tracheal adenocystic carcinoma. Patient was made operation as thoracotomy and tracheal tumor was removed at the 28th week of pregnancy. Patient was delivered with sectio abdominale at the 39th week of pregnancy. Primary tracheal adenocystic carcinoma is very rarely seen tumors and it is the first tracheal ACC with pregnancy case in literature to have been detected and surgically treated during pregnancy. We discussed primary tracheal adenocystic carcinoma and tracheal tumors during pregnancy with literature.
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Affiliation(s)
- Faruk Abike
- Department of Obstetrics Gynecology, Bayindir Hospital, Ankara
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