• Cancer
• Children
• Late effects
• Survivorship
• Treatment

• cancer survivorship
• childhood cancer
• ecological systems theory
• focus groups
• long-term follow-up studies

• Humans
• Cancer Survivors/psychology
• Cancer Survivors/statistics & numerical data
• Focus Groups
• Female
• Male
• Child
• Adolescent
• Germany
• Neoplasms/therapy
• Long-Term Care
• Qualitative Research
• Follow-Up Studies
• Aftercare

• Cancer
• Children
• General practice
• Implementation science
• Oncology
• Qualitative research
• Telemedicine
• eHealth

• Humans
• Telemedicine
• Cancer Survivors/psychology
• Male
• Female
• Qualitative Research
• Adult
• Middle Aged
• Aged
• Young Adult
• Adolescent
• Neoplasms/therapy
• Neoplasms/psychology
• Follow-Up Studies
• Aftercare/methods
• Child
• Continuity of Patient Care
• Prospective Studies
• Child, Preschool

• Cancer
• Children and adolescent
• Long-term care
• Multidisciplinary
• Psychosocial

• Humans
• Child
• Adolescent
• Cancer Survivors/psychology
• Quality of Life
• Prospective Studies
• Multicenter Studies as Topic
• Germany
• Randomized Controlled Trials as Topic
• Neoplasms/therapy
• Neoplasms/psychology
• Long-Term Care
• Self Efficacy
• Time Factors
• Patient Care Team
• Treatment Outcome
• Patient Satisfaction
• Mental Health
• Adaptation, Psychological
• Female
• Male
• Psychosocial Intervention/methods

• CNS tumor
• Survivor
• Telehealth

• Adult
• Child
• Humans
• Caregivers
• Cross-Sectional Studies
• Telemedicine
• Survivors
• Central Nervous System Neoplasms/therapy

• P50 HD105351 NICHD NIH HHS

• Aftercare
• Childhood cancer
• Psychosocial support
• Young adult survivors

• Adolescent
• Humans
• Child
• Young Adult
• Adult
• Cancer Survivors/psychology
• Neoplasms/therapy
• Neoplasms/psychology
• Psychosocial Support Systems
• Austria
• Survivors/psychology
• Aftercare/psychology

• Österreichische Kinder-Krebs-Hilfe
• Medical University of Vienna

• cancer survivorship
• long-term follow-up care
• peer mentoring
• self-management

• P30 CA072720 NCI NIH HHS
• R21 CA222936 NCI NIH HHS

• After care
• brain tumor
• late effects
• long-term follow up
• pediatric neuro-oncology
• pediatric oncology
• survivorship

Children with cancer are frequently hospitalized during diagnosis and treatment. Since the early 1980s, parents are co-admitted because their presence positively affects children’s adjustment to hospitalization and reduces post-traumatic stress. However, the size and overall architectural design of the rooms were never adapted to the doubling of the occupancy rate. Since studies show that many parents experience high levels of distress due to their child’s illness, the purpose of this study was to investigate the impact of the architecture of the aged patient rooms on parental distress. A video observation targeted parent–child interaction related to five architectural determinants: (a) function and place of interaction, (b) distance between parent and child, (c) used space, (d) withdrawal, and (e) duration of the interaction. A total of 22 families were included in two Dutch children’s hospitals. Results show a significant association between parental distress and three architectural determinants: The less anxious the parents were and the better they estimated their child’s well-being, the more distance they created between themselves and their child, and the more space, privacy, and withdrawal options were used. These findings are discussed within a new patient room typology, the parent–child patient unit (PCPU), which reacts to the evident association of parental distress and the design.

• architectural psychology
• child well-being
• design criteria
• evidence-based design
• hospital design
• hospitalization
• oncology
• parental health
• parent–child interaction
• privacy

• Aged
• Anxiety
• Child
• Child Behavior
• Humans
• Neoplasms
• Parent-Child Relations
• Patients' Rooms

• aftercare
• cancer survivors
• health services needs and demand
• long-term cancer survivors
• needs assessment
• neoplasm
• patient preference
• psycho-oncology
• psychosocial support systems
• qualitative research

Various breast cancer (BC) treatments, such as chemotherapy and targeted therapies, increase cardiotoxicity-risk and lead to premature ischemic heart disease and heart failure among survivors. Reducing this adverse risk through early recognition and (preventive) treatment is therefore important. Conversely, we feel that screening for cardiotoxicity is currently insufficiently standardized in daily practice. A fundamental first step in identifying areas of improvement is providing an overview of current practice.

This study aims to describe current cardiac surveillance for women with BC during and after cardiotoxic cancer treatment, using routinely collected hospital data in the Netherlands. The study also describes hospital variation in cardiac surveillance.

This observational study was performed on claims data provided by Statistics Netherlands. From the data, newly diagnosed BC patients in 2013 (N = 16,040) were selected and followed up until 2015. Healthcare utilization analyses were performed for all cardiac and oncologic healthcare activities but with a specific focus on cardiac surveillance healthcare activities. In addition, differences between types and individual hospitals were evaluated.

Almost one third of all BC patients received high risk cardiotoxic treatments (N = 5157), but cardiac surveillance was rarely performed. Cardiac care provided to patients mainly consisted of ECGs (52.0%) and MUGA scans (26.5%). Cardiac MRI was performed in 0.7% of the patients, echocardiography in 17.7%, and measurement of Troponin and NT-proBNP in 5.1 and 5.8%, respectively. Moreover, we observed a substantial variation in cardiac surveillance between different hospital types and between individual hospitals.

This study shows that women treated for BC with cardiotoxic treatments do not receive recommended cardiac surveillance. Standardized approaches in clinical care are lacking, resulting in low rates of diagnostic testing and a substantial variation in surveillance between hospitals. A structured approach and increased interprofessional collaboration could lead to tailored cardiac surveillance for early detection of cardiotoxicity and therefore start of treatment.

• Breast cancer
• Cardiac imaging
• Cardiotoxicity
• Epidemiology
• Health policy
• Quality of care

The Hungarian Pediatric Oncology Network provides centralized treatment and population-based registration for cases of childhood cancer since 1973. We collected and analized data on late mortality, secondary malignancies and cardiac diseases in survivors (> 5 years) of childhood cancer to evaluate long-term risks. We extracted all solid tumour cases (3,650 followed up for 5–39.3 years, diagnosis: 1973–2008) from the database of the Hungarian Childhood Cancer Registry and checked against the Population Registry. Among the 301 patients who died after 5 years (8.2%) the most common causes of death were progression of primary cancer (52.5%), secondary malignancies (16%) and cardiovascular diseases (8%). Late mortality rates (SMR, total: 35,006 pyrs) showed highly elevated risk of death (SMR: 10.7 95% CI 9–12.4) for the second 5 years of follow up and moderately elevated risk for 10-year survivors (SMR: 3.5 95% CI 3–4.1). Marked differences were detected in the pattern of causes of death between diagnostic groups of primary cancer; with highest risks beyond 10 years for CNS tumours, Hodgkin disease, osteosarcoma and advanced stage neuroblastoma. The longstanding mortality risk for 5-year survivors underlines the need for tailored long-term follow-up and monitoring of late consequences according to the context of different primary diseases of childhood cancer.

• Childhood cancer survivor
• Late effects
• Long-term follow-up

• Childhood cancer
• Late effects of cancer treatment
• Screening
• Survivorship

• Antineoplastic Protocols
• Breast Neoplasms/diagnosis
• Breast Neoplasms/pathology
• Cancer Survivors
• Cardiotoxicity/diagnosis
• Cardiotoxicity/epidemiology
• Cardiotoxicity/etiology
• Child
• Colorectal Neoplasms/diagnosis
• Colorectal Neoplasms/pathology
• Early Detection of Cancer/methods
• Early Detection of Cancer/standards
• Early Detection of Cancer/statistics & numerical data
• Female
• Guideline Adherence/standards
• Guideline Adherence/statistics & numerical data
• Humans
• Late Onset Disorders/diagnosis
• Late Onset Disorders/epidemiology
• Late Onset Disorders/etiology
• Mass Screening/methods
• Mass Screening/organization & administration
• Mass Screening/standards
• Monitoring, Physiologic/standards
• Monitoring, Physiologic/statistics & numerical data
• Practice Patterns, Physicians'/organization & administration
• Practice Patterns, Physicians'/standards
• Program Evaluation
• Quality Improvement/organization & administration
• Quality Improvement/standards
• Telephone

• Aftercare, long-term
• Delivery of health care
• Endocrine system diseases
• Interdisciplinary communication
• Models of care

• follow-up care
• healthcare providers
• late effects
• qualitative
• survivorship

• AfterCare
• late effects
• long-term follow-up
• pediatric oncology
• survivorship

• follow-up care
• late effects
• long-term follow-up
• loss to follow-up
• survival
• survivorship

• Swiss Childhood Cancer Survivor Study
• adolescent survivors
• follow-up care
• health beliefs

• childhood cancer
• colorectal
• screening
• survivor

• adolescent
• adverse effects
• child
• neoplasms
• practice guideline
• survivors

• Attitude of Health Personnel
• Child
• Child, Preschool
• Delivery of Health Care/statistics & numerical data
• Europe
• Guideline Adherence/statistics & numerical data
• Guidelines as Topic
• Humans
• Medical Staff/psychology
• Neoplasms/therapy
• Surveys and Questionnaires

Testicular cancer (TC) is the most curable type of cancer, with a survival rate of more than 95%. Oncologists are faced with the challenge that gonadotoxic cancer treatments can compromise future fertility, either temporarily or permanently. Our aim was to investigate the long-term effects of TC treatments on male fertility and on the offspring of patients who had received these treatments. Between January 1996 and December 2010, 125 eligible patients, ranging from 18 to 54 years (median age 36.3 ± 15.7), with unilateral TC underwent surgery, chemotherapy or radiotherapy at our center. Some of these patients had their semen samples cryopreserved in the Shanghai Human Sperm Bank. The clinical data were evaluated, and questionnaire and telephone follow-up surveys were given to all patients. The data were analyzed to determine the patients’ fertility status pre- and posttreatment. Of the 125 eligible patients, 93.6% (117/125) were accessible and were evaluated. Among 81 men who were married before diagnosis, 21 had conceived successfully before diagnosis and six reported azoospermia. Posttreatment conception was attempted by 73 men; of these, 16 conceived naturally and 19 conceived by artificial reproductive techniques, resulting in 37 healthy babies with no congenital malformations. Of the patients who had not conceived before treatment, 21.9% (21/96) banked their sperm and 23.8% of these patients (5/21) subsequently used the banked sperm. Retroperitoneal lymph node dissection, chemotherapy and radiotherapy were the most highly correlated with lack of conception post-TC treatment. Sperm banking should be recommended to TC patients with the desire for biological conception. There is no evidence to suggest that TC treatments are associated with birth defects or childhood malignancies.

• clinical prediction tool
• late effects
• risk prediction model
• second cancers

• K05 CA160724 NCI NIH HHS
• P30 CA008748 NCI NIH HHS
• R01 CA134722 NCI NIH HHS
• R01 CA136783 NCI NIH HHS

• Endocrinology
• Neurodisability
• Oncology
• Outcomes research
• Paediatric Practice

• childhood cancer
• family physician
• follow-up
• general practitioner
• primary care
• survivor

For many childhood cancer survivors follow-up care is important long after treatment completion. We aimed to describe the availability and characteristics of long-term follow-up programs (LTFU) across Europe, their content and aims, their problems, and to assess opinions on different models of LTFU.

We asked 179 pediatric oncology institutions in 20 European countries to complete an online survey on LTFU available at their institution. Of 110 respondents (62% response), 66% reported having LTFU for pediatric survivors, 38% for adult survivors of childhood cancer. Availability varied widely across European regions, from 9% of institutions in Northern Europe reporting LTFU for adult survivors to 83% of institution on the British Isles reporting LTFU for pediatric survivors. Pediatric and adult LTFU were usually located in pediatric hospitals and run by pediatric oncologists. Content of follow-up included screening for adverse outcomes and health education. Important problems included lack of time, personnel and funding. Most institutions without LTFU reported that they would like to offer a program (86%).

Despite general agreement on the need of follow-up care, there is still a lack of well-organized LTFU for survivors of childhood cancer across Europe.

• Canada
• Child
• Delivery of Health Care
• Follow-Up Studies
• Humans
• Long-Term Care
• Neoplasms
• Pediatrics/standards
• Physicians, Family
• Surveys and Questionnaires
• Survivors