• Extracellular vesicle
• Fluorescence guided surgery
• Near-infrared fluorescent probe
• Prostate cancer
• STEAP1

• Male
• Animals
• Prostatic Neoplasms/surgery
• Prostatic Neoplasms/diagnostic imaging
• Prostatic Neoplasms/metabolism
• Humans
• Fluorescent Dyes/administration & dosage
• Fluorescent Dyes/pharmacokinetics
• Fluorescent Dyes/chemistry
• Extracellular Vesicles/metabolism
• Cell Line, Tumor
• Optical Imaging
• Surgery, Computer-Assisted/methods
• Mice, Nude
• Mice
• Mice, Inbred BALB C
• Oxidoreductases/metabolism
• Antigens, Neoplasm

• Retzius-sparing technique
• functional recovery
• oncological outcomes
• prostate cancer
• quality of life
• radical prostatectomy
• robotic-assisted surgery
• single-port robotics
• surgical innovation
• urinary continence

• extraperitoneal
• nephrectomy
• radical cystectomy
• radical prostatectomy
• retroperitoneal
• single-port
• transvesical
• urologic oncology

• Perioperative outcome
• Prostate cancer
• Randomized clinical trial
• Robot-assisted radical prostatectomy
• Technological innovations

• Humans
• Male
• Prostatectomy/methods
• Prostatectomy/adverse effects
• Robotic Surgical Procedures/methods
• Robotic Surgical Procedures/adverse effects
• Prostatic Neoplasms/surgery
• Middle Aged
• Aged
• Prospective Studies
• Feasibility Studies
• Treatment Outcome
• Operative Time
• Postoperative Complications/epidemiology
• Postoperative Complications/etiology

• Electromagnetic tracking
• Fiber Bragg gratings
• Navigation method
• Single-port transvesical radical prostatectomy
• Soft robot system

• Humans
• Male
• Prostatectomy/methods
• Prostatectomy/instrumentation
• Robotic Surgical Procedures/methods
• Robotic Surgical Procedures/instrumentation
• Prostatic Neoplasms/surgery
• Equipment Design
• Phantoms, Imaging
• Surgery, Computer-Assisted/methods
• Surgery, Computer-Assisted/instrumentation
• Laparoscopy/methods
• Laparoscopy/instrumentation

• 62133009 National Natural Science Foundation of China
• 61973211 National Natural Science Foundation of China
• 62211540723 National Natural Science Foundation of China
• M-0221 National Natural Science Foundation of China
• 21550714200 Science and Technology Commission of Shanghai Municipality
• 20DZ2220400 Science and Technology Commission of Shanghai Municipality
• 2022I0041 Foreign Cooperation Project of Fujian Province Science and Technology Program
• 2021C003R Quanzhou High-level Talent Innovation and Entrepreneurship
• 2021-008 the Hospital-local Cooperation Project of Xuhui District Artificial Intelligence Medicine
• 21XJMR03 the Joint Project of Xinhua Hospital and Institute of Medical Robotics of Shanghai Jiao Tong University

• bibliometrics
• citespace
• image-guided surgery
• prostate cancer
• vosviewer

• Humans
• Bibliometrics
• Male
• Prostatic Neoplasms/surgery
• Prostatic Neoplasms/diagnostic imaging
• Prostatic Neoplasms/pathology
• Surgery, Computer-Assisted/methods
• Prostatectomy/methods
• Prostatectomy/statistics & numerical data

• Airway pressure
• Diaphragm ultrasound
• Lung compliance
• Lung injury
• Robot-assisted laparoscopic surgery

• Humans
• Diaphragm
• Head-Down Tilt
• Pneumoperitoneum
• Pulmonary Surfactant-Associated Protein D
• Robotic Surgical Procedures
• Robotics
• Respiration
• Laparoscopy

• 81870875 National Natural Science Foundation of China
• 81870875 National Natural Science Foundation of China
• 81870875 National Natural Science Foundation of China
• 81870875 National Natural Science Foundation of China
• 81870875 National Natural Science Foundation of China
• 81870875 National Natural Science Foundation of China
• 81870875 National Natural Science Foundation of China

• image-guided surgery
• minimally invasive
• robot-assisted
• robotic urologic surgery
• single port robot

• Prostate cancer
• Robotic surgery
• Urinary continence
• Vesicoprostatic muscle reconstruction

• 21BJZ27 PLA General Hospital

• anatomy
• prostate cancer
• prostatectomy
• robotics
• space of Retzius
• urinary incontinence

• Humans
• Male
• Prospective Studies
• Prostate
• Prostatectomy/adverse effects
• Prostatectomy/methods
• Recovery of Function/physiology
• Robotic Surgical Procedures/adverse effects
• Robotic Surgical Procedures/methods
• Treatment Outcome
• Urinary Incontinence/etiology
• Urinary Incontinence/prevention & control

• Laparoscopic surgery
• Prostate cancer
• Prostatectomy
• Robotic-assisted surgery
• Urologic surgical procedures

Background and objectives: The aim of this systematic review is to evaluate the impact of radical prostatectomy (RP) on bladder function, with special attention towards detrusor underactivity investigated with the means of urodynamic evaluation. Materials and Methods: The review was performed in accordance with the PRISMA statement and was registered in the PROSPERO (ID#: CRD42020223480). The studied population was limited to men with prostate cancer who underwent urodynamic study prior to and after radical prostatectomy. Eight hundred twenty-seven studies were screened, with twenty-five finally included. A qualitative analysis was performed. Rates of detrusor underactivity (DU) before surgery were reported in eight studies and ranged from 1.6% to 75% (median of 40.8%). DU occurred de novo after RP in 9.1% to 37% of patients (median of 29.1%). On the other hand, preexisting DU resolved in 7% to 35.5% of affected men. Detrusor overactivity (DO) was the most frequently reported outcome, being assessed in 23 studies. The rate of DO preoperatively was from 5% to 76% (median of 25%). De novo was reported in 2.3–54.4% of patients (median of 15%) and resolved after RP in 19.6% to 87.5% (median of 33%) of affected patients. Baseline rates of bladder outlet obstruction (BOO) varied between studies from 19% to 59.3%, with a median of 27.8%. The most pronounced change after surgery was the resolution of BOO in 88% to 93.8% (median of 92%) of affected patients. Results: Rates of de novo impaired bladder compliance (IBC) varied from 3.2% to 41.3% (median of 13.3%), whereas the resolution of IBC was reported with rates ranging from 0% to 47% (median of 4.8%). Conclusions: BOO, DO, and DU are frequently diagnosed in men scheduled for RP. BOO is improved after RP in most patients; however, there is still a substantial rate of patients with de novo DU as well as DO which may impair functional outcomes and quality of life.

Upper urinary tract stones are very common in my country, with an incidence of 1% to 5% in the North and an even higher incidence of 5% to 10% in the south. The incidence rate in the south is higher than that in the north, mainly due to the water quality, climate and eating habits of the region. From the perspective of sex, incidence is more likely in males than females. In the high-incidence population, young adults are most prone to stones. Men in the age range of 25 to 40 years are more likely to have stones.

To observe the therapeutic effect of minimally invasive percutaneous nephrolithotomy (mPCNL) on upper urinary tract stones and its influence on the renal function of patients.

Patients with upper urinary tract stones who were treated in our hospital from February 2017 to March 2018 were selected as research subjects and were divided into the PCNL group and the mPCNL group according to the random number table method. The general conditions of the two groups of patients were observed during the perioperative period, and the differences in stone clearance, pain, renal function indicators and complication rates were compared between the two groups to determine which were statistically significant (P < 0.05).

The operation time of the mPCNL group was longer than that of the PCNL group (t = -34.392, P < 0.001), and the intraoperative blood loss of the mPCNL group was more than that of the PCNL group (t = 34.090, P < 0.001). There was no difference in renal function indices between the two groups of patients before treatment, and there was no difference in the levels of serum creatinine, β2 microglobulin or retinol binding protein in the mPCNL group after treatment. The visual analog scale score of patients in the mPCNL group was lower than that of the PCNL group (t = 12.191, P < 0.001), and there was no significant difference in the stone clearance rate between the two groups (χ² value = 1.013, P = 0.314). There was no significant difference in the incidence of urine extravasation, dyspnea and peripheral organ damage between the two groups (χ² value = 1.053, P = 0.305). At 1 mo after treatment and 3 mo after treatment, the quality of life of the mPCNL group was lower than that of the PCNL group, and the Qmax level of the mPCNL group was higher than that of the PCNL group.

mPCNL has a good therapeutic effect on upper urinary tract stones, with a high stone clearance rate without causing kidney damage or increasing the incidence of complications, and thus has good application value.

• Percutaneous nephrolithotomy
• Minimally invasive percutaneous nephrolithotomy
• Upper urinary calculi
• Calculi
• Renal function
• Complications

Our team had firstly applied the transvesical approach to robot-assisted radical prostatectomy (RARP) in patients afflicted with localized prostate cancer (PCa). The present study aims to present the postoperative recovery of urinary continence (UC) following the anterior, transvesical, and posterior approaches to RARP for localized PCa and evaluate the independent predictors to early UC recovery after RARP.

Patients harboring localized PCa and receiving anterior, transvesical, and posterior approaches to RARP between January 2017 and June 2020 were enrolled in this analysis. Results on UC recovery were compared between these three approaches with the Kaplan–Meier method. All clinical and pathological variables were further analyzed via univariable and multivariable regression analysis to determine the independent factors contributing to short-term UC recovery after RARP.

A total of 135, 73, and 66 instances were included in the anterior, transvesical, and posterior groups, respectively. Over the postoperative follow-up period, both the transvesical and posterior approaches showed an advantage over the anterior approach in promoting postoperative UC recovery (both p values <0.001). Three months after surgery, 55 (40.7%), 4 (5.5%), and 5 (7.6%) patients failed to UC in the anterior, transvesical, and posterior groups, respectively. Patient age, preoperative PSA, prostate volume, biopsy Gleason score, surgical approach, extended lymph node dissection technique, nerve-sparing technique, and positive lymph node were related to UC status based on univariable analyses (p < 0.05). Multivariable analysis results point patient age, prostate volume, surgical approach, and nerve-sparing technique as independent factors that affect postoperative UC recovery after RARP.

The application of transvesical approach to RARP for localized PCa could obtain promising outcomes in terms of postoperative UC recovery. In addition, surgical strategies encompassing the nerve-sparing technique and the Retzius-sparing procedures, namely, the transvesical or posterior approach, during RARP could independently enable early achievement of postoperative continence.

• Erectile dysfunction
• prostate cancer
• prostatectomy

• extravesical
• laparoscopic
• posthysterectomy
• transvesical
• vesicovaginal fistula

• Retzius-sparing
• prostate cancer
• robot-assisted radical prostatectomy
• standard approach
• transvesical approach

To assess the perioperative, functional, and oncological outcomes of transvesical robot-assisted radical prostatectomy (T-RARP) and posterior robot-assisted radical prostatectomy (P-RARP) for localized prostate cancer.

We analyzed the data of 96 patients who underwent T-RARP or P-RARP for localized prostate cancer between January 2017 and June 2019 in a retrospective fashion.

No significant differences in the baseline characteristics existed between the T-RARP and P-RARP arms. Both interventions were successfully performed without open conversion in either group. T-RARP was associated with a slightly more operative time (135.3 vs. 127.3 min) and estimated blood loss (105.2 vs. 94.2 mL) than P-RARP, but the differences were not significant (both p > 0.05). The likelihood of transfusion, ≤Grade II, and >Grade II postoperative complications, pT3a disease and positive surgical margins in the T-RARP group was comparable with that in the P-RARP group. No significant differences were noted between these two arms in terms of UC at the removal of catheter and nocturia (p = 0.750 and p = 0.684, respectively), and all included patients recovered UC at 3 months postoperatively. The median International Index of Erectile Function-5 score in both groups remains comparable before and after RARP. The patients in the T-RARP and P-RARP groups had a similar biochemical recurrence-free survival (p = 0.387).

Both T-RARP and P-RARP by experienced hands are feasible for well-selected patients with prostate cancer, obtaining similar outcomes in terms of perioperative results, UC and erectile function, and oncological control within short-term follow-up.

• Retzius-sparing
• posterior approach
• prostate cancer
• robot-assisted radical prostatectomy
• transvesical approach

• lower urinary tract dysfunction
• nerve sparing
• prostate cancer
• robot